Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-08T06:28:25.475Z Has data issue: false hasContentIssue false

Serious sequels of Kawasaki disease

Published online by Cambridge University Press:  19 August 2008

Nam Su Kim
Affiliation:
Department of Cardiology, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia
Samuel Menahem*
Affiliation:
Department of Cardiology, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia
*
Samuel Menahem, Department of Cardiology, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia.

Abstract

A male infant, aged 2 month, with Kawasaki disease had a myocardial infarction despite intravenous infusions of gamma globulin and aspirin at high dosage. He developed progressively a thin walled, dilated aneurysm of the apex of the left ventricle which became lined with thrombus despite treatment with warfarin. Another boy, aged 6 years, was noted on the 10th day of the evolution of Kawasaki disease to have developed a giant aneurysm of the main stem of the left coronary artery. Despite infusion of gamma globulin, the aneurysm remained unaltered and developed a thrombus. The thrombus resolved following treatment with warfarin, though the giant aneurysm has persisted. These two cases illustrate the serious consequences that can follow Kawasaki disease despite management optimal by current standards.

Type
Brief Report
Copyright
Copyright © Cambridge University Press 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Kato, H, Hara, T, Inoue, O, Sato, N, Akagi, T, Sugimura, T. Current issues in Kawasaki disease. Acta Paediatr Jpn 1993; 35: 464471.CrossRefGoogle ScholarPubMed
2.Kato, H, Ichinose, E, Kawasaki, T. Myocardial infarction in Kawasaki disease: clinical analyses in 195 cases. J pediatr 1986; 108: 923927.CrossRefGoogle ScholarPubMed
3.Suma, K, Takeuchi, Y, Shiroma, K, Tsuji, T, Inoue, K, Yoshikawa, T, Koyama, Y, Narumi, J, Asai, T, Kusakawa, S. Cardiac surgery of eight children with Kawasaki disease (mucocutaneous lymph node syndrome). Jpn Heart J 1981; 22: 605616.CrossRefGoogle ScholarPubMed
4.Mavroudis, C, Backer, CL, Muster, AJ, Pahl, E, Sanders, JH, Zales, VR, Gevitz, M. Expanding indications for pediatric coronary artery bypass. J Thorac Cardiovasc Surg 1996; 111: 181189.CrossRefGoogle ScholarPubMed
5.Ino, T, Akimoto, K, Ohkubo, M, Nishimoto, K, Yabuta, K, Takaya, J, Yamaguchi, H. Application of percutaneous transluminal coronary angioplasty to coronary arterial stenosis in Kawasaki disease. Circulation 1996; 93: 17091715.CrossRefGoogle ScholarPubMed
6.Nakano, H, Saito, A, Ueda, K, Nojima, K. Clinical characteristics of myocardial infarction following Kawasaki disease: report of 11 cases. J Pediatr 1986, 108: 198203.CrossRefGoogle ScholarPubMed
7.Rosenfeld, EA, Conydon, KE, Shulman, ST. Kawasaki disease in infants less than one year of age. J Pediatr 1995; 126: 524529.CrossRefGoogle ScholarPubMed
8.Dajani, AS, Taubert, KA, Takahashi, M, Bierman, FZ, Freed, MD, Ferrieri, P, Gerber, M, Shulman, ST, Karchmer, AW, Wilson, W, Peter, G, Durack, DT, Rahimtoola, SH. Guidelines for longterm management of patients with Kawasaki disease. Report from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 1994; 89: 916922.CrossRefGoogle ScholarPubMed
9.Kato, H, Inoue, O, Ichinose, E, Akagi, T, Sato, N. Intracoronary urokinase in Kawasaki disease: treatment and prevention of myocardial infarction. Acta Paediatr Jpn 1991; 33: 2735.CrossRefGoogle ScholarPubMed
10.Andrew, M, Marzinotto, V, Brooker, LA, Adams, M, Ginsberg, J, Freedom, R, Williams, W. Oral anticoagulation therapy in pediatric patients: a prospective study. Thromb Haemostas 1994; 71: 265269.Google ScholarPubMed