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Recurrent acute kidney injury is associated with delayed language development in infants with Congenital Heart Disease

Published online by Cambridge University Press:  10 October 2024

Chetna K. Pande Open the ORCID record for Chetna K. Pande [Opens in a new window] ,
Ayse Akcan-Arikan ,
Sonia Monteiro ,
Danielle Guffey ,
Faridis Serrano Open the ORCID record for Faridis Serrano [Opens in a new window] ,
Natasha Afonso ,
Kriti Puri Open the ORCID record for Kriti Puri [Opens in a new window] ,
Barbara-Jo Achuff ,
Lara Shekerdemian  and
Lisa Noll
Chetna K. Pande*
Affiliation:
Division of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, USA
Ayse Akcan-Arikan
Affiliation:
Division of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, USA Division of Nephrology, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, USA
Sonia Monteiro
Affiliation:
Division of Developmental Pediatrics, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, USA
Danielle Guffey
Affiliation:
Institute for Clinical and Translational research, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
Faridis Serrano
Affiliation:
Division of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, USA
Natasha Afonso
Affiliation:
Division of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, USA
Kriti Puri
Affiliation:
Division of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, USA
Barbara-Jo Achuff
Affiliation:
Division of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, USA
Lara Shekerdemian
Affiliation:
Division of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, USA
Lisa Noll
Affiliation:
Division of Psychology, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, USA
*
Corresponding author: Chetna K. Pande; Email: [email protected]
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Abstract

Objective:

Neurodevelopmental delay is common in children who undergo surgery for Congenital Heart Disease (CHD) in infancy. Cardiac surgery associated acute kidney injury (CS-AKI) occurs frequently in the paediatric cardiac Intensive care unit (ICU). Cardiac surgery associated acute kidney injury (CS-AKI) is associated with worse neurodevelopmental scores and delay in cognitive, language, and motor domains in children with CHD. No known data exist regarding the association of CS-AKI and motor and language subscales. In this study, we explored the relationship between CS-AKI and receptive and expressive language, as well as gross and fine motor delay.

Methods:

This was a single centre retrospective observational cohort study. Children who underwent surgery for CHD and developed recurrent CS-AKI in the first year of life who had follow-up neurodevelopmental testing using the Bayley Scale of Infant Development Version III were included. Neurodevelopmental delay subscales assessed included: receptive and expressive language, fine and motor skills.

Results:

The study cohort included 203 children. Recurrent CS-AKI was significantly associated with lower scores in receptive and expressive language, as well as fine and gross motor on unadjusted analyses. On adjusted analyses, recurrent CS-AKI was significantly associated with severe receptive language delay.

Conclusion:

The independent association of recurrent CS-AKI with severe language delay in children who undergo surgery for CHD in infancy is novel. Our findings may contribute to the understanding of language impairment in this population. Further studies are required to better understand this relationship and any potentially modifiable factors.

Keywords

Congenital heart surgeryacute kidney injuryneurodevelopmental delaylanguage
Type
Original Article
Information
Cardiology in the Young , Volume 34 , Issue 11 , November 2024 , pp. 2377 - 2381
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Copyright
© The Author(s), 2024. Published by Cambridge University Press

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