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Poor correlation of venous lactate with systemic oxygen saturation in the paediatric cardiac ICU: a pilot study

Published online by Cambridge University Press:  23 October 2024

Rohit S. Loomba Open the ORCID record for Rohit S. Loomba [Opens in a new window] ,
Enrique G. Villarreal Open the ORCID record for Enrique G. Villarreal [Opens in a new window] ,
Angela Klein ,
Juan S. Farias Open the ORCID record for Juan S. Farias [Opens in a new window] ,
Saul Flores Open the ORCID record for Saul Flores [Opens in a new window]  and
Nina Censoplano
Rohit S. Loomba
Affiliation:
Division of Cardiology, Advocate Children’s Hospital, Oak Lawn, IL, USA Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
Enrique G. Villarreal*
Affiliation:
Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Nuevo Leon, Mexico
Angela Klein
Affiliation:
Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
Juan S. Farias
Affiliation:
Children’s Mercy Hospital, Kansas City, MO, USA
Saul Flores
Affiliation:
Texas Children’s Hospital/Baylor College of Medicine, Division of Critical Care, Houston, TX, USA
Nina Censoplano
Affiliation:
Division of Cardiology, Advocate Children’s Hospital, Oak Lawn, IL, USA
*
Corresponding author: Enrique G. Villarreal; Email: [email protected]
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Abstract

Introduction:

Cardiac intensive care providers require a comprehensive understanding of cardiac output and oxygen delivery. The estimation of cardiac output in clinical practice often relies on thermodilution and the Fick principle. Central venous saturation and lactate levels are commonly used indicators for cardiac output assessment. However, the relationship between venous lactate levels and venous oxygen saturation in paediatric cardiac intensive care patients remains unclear.

Methods:

This is a single-centre retrospective pilot study aimed to investigate the correlation between venous lactate and venous oxygen saturation in paediatric patients. Data collected included venous saturation, heart rate, mean arterial blood pressure, arterial saturation by pulse oximetry, cerebral and renal near-infra-red spectroscopy values, and the presence of a functionally univentricular heart. Statistical analyses included Bayesian Pearson correlation and regression analyses.

Results:

A total of 203 data points from 37 unique patients were included in the analysis. There was no significant correlation between serum lactate and venous saturation (correlation coefficient = –0.01; Bayes factor 10 = 0.06). Serum lactate also did not correlate with other haemodynamic metrics. Venous saturation showed correlations with arterial saturation and cerebral and renal near-infra-red spectroscopy. Regression analysis revealed that parallel circulation, arterial saturation, and cerebral near-infra-red spectroscopy were predictive of venous saturation. The following equation resulted from the regression analysis: 68.0 – (12.7 x parallel circulation) – (0.8 x arterial saturation) + (0.3 x cerebral near-infra-red spectroscopy). This model had a Bayes factor 10 of 0.03 and adjusted R-squared was 0.29.

Conclusion:

In paediatric cardiac intensive care patients, there is no significant correlation between venous lactate and venous saturation, suggesting that lactate may not be a reliable marker for assessing the adequacy of oxygen delivery in this population. Only a weak correlation could be identified once the venous saturation was 70% or lower. Additional research is needed to explore alternative markers for monitoring oxygen delivery in critically ill paediatric patients.

Keywords

cardiac outputlactic acidpaediatric ICUshaemodynamic monitoringpaediatrics
Type
Original Article
Information
Cardiology in the Young , Volume 35 , Issue 1 , January 2025 , pp. 157 - 161
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Copyright
© The Author(s), 2024. Published by Cambridge University Press

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