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Neonatal ascending aortic thrombus: successful medical treatment

Published online by Cambridge University Press:  03 October 2012

Roberto Gallotti
Affiliation:
Division of Pediatric Cardiothoracic Surgery, Wake Forest Baptist Health, Winston-Salem, North Carolina, United States of America
Cheryl E. Cammock
Affiliation:
Division of Pediatric Cardiology, Wake Forest Baptist Health, Winston-Salem, North Carolina, United States of America
Natalia Dixon
Affiliation:
Division of Pediatrics Hematology-Oncology, Wake Forest Baptist Health, Winston-Salem, North Carolina, United States of America
Yoshio Ootaki*
Affiliation:
Division of Pediatric Cardiothoracic Surgery, Wake Forest Baptist Health, Winston-Salem, North Carolina, United States of America
*
Correspondence to: Dr Y. Ootaki, MD, PhD, Division of Pediatric Cardiothoracic Surgery, Wake Forest Baptist Health, Medical Center Boulevard, Winston-Salem, North Carolina 27157, United States of America. Tel: +1336 716 2218; Fax: +1336 713 2242; E-mail: [email protected]

Abstract

Neonatal aortic thrombosis is a potentially life-threatening condition with significant morbidity and mortality if undiagnosed and untreated. The most common location of arterial thrombosis in neonates is in the abdominal aorta and is associated with umbilical artery catheterisation. There are only a few previous reports of thrombosis in the ascending aorta. We describe a case of ascending aortic thrombosis in a neonate who underwent successful thrombolytic therapy.

Type
Brief Reports
Copyright
Copyright © Cambridge University Press 2012 

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References

1. Schmidt, B, Andrew, M. Neonatal thrombosis: report of a prospective Canadian and international registry. Pediatrics 1995; 96: 939943.CrossRefGoogle ScholarPubMed
2. Das, B, Sahoo, S, Ivy, D. Neonatal aortic arch thrombosis masquerading as coarctation of the aorta. Pediatr Cardiol 2004; 25: 8083.CrossRefGoogle ScholarPubMed
3. Francis, J, Monagle, P, Hope, S, Sehgal, A. Occlusive aortic arch thrombus in a preterm neonate. Pediatr Crit Care Med 2010; 11: e13e15.CrossRefGoogle Scholar
4. Wang, M, Hays, T, Balasa, V, et al. Low-dose tissue plasminogen activator thrombolysis in children. J Pediatr Hematol Oncol 2003; 25: 379386.CrossRefGoogle ScholarPubMed
5. Nowak-Gottle, U, von Kries, R, Gobel, U. Neonatal symptomatic thromboembolism in Germany: two year survey. Arch Dis Child Fetal Neonatal Ed 1997; 76: F163F167.CrossRefGoogle Scholar
6. Klinger, G, Hellmann, J, Daneman, A. Severe aortic thrombus in the neonate – successful treatment with low-molecular-weight heparin: two case report and review of literature. Am J Perinatol 2000; 17: 151158.CrossRefGoogle Scholar
7. Monagle, P, Chalmers, E, Chan, A, et al. Antithrombotic therapy in neonates and children: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133: 887S968S.CrossRefGoogle ScholarPubMed
8. Monagle, P, Michelson, AD, Bovil, E, Andrew, M. Antithrombotic therapy in children. Chest 2001; 119: 344S370S.CrossRefGoogle ScholarPubMed
9. Greenway, A, Massicotte, MP, Monagle, P. Neonatal thrombosis and its treatment. Blood Rev 2004; 18: 7584.CrossRefGoogle ScholarPubMed
10. Zenz, W, Arlt, F, Sodia, S, Berghold, A. Intracerebral hemorrhage during fibrinolytic therapy in children: a review of the literature of the last thirty years. Semin Thromb Hemost 1997; 23: 321332.CrossRefGoogle ScholarPubMed
11. McFaul, RC, Keane, JF, Nowicki, ER, Castaneda, AR. Aortic thrombosis in the neonate. J Thorac Cardiovasc Surg 1981; 81: 334337.CrossRefGoogle ScholarPubMed
12. Trowitzsch, E, Bernsau, U, Luhmer, I, Merkle, W, Kallfelz, HC. Congenital thrombotic occlusion of the ascending aorta and the aortic arch. Pediatr Cardiol 1985; 6: 165169.CrossRefGoogle ScholarPubMed
13. Scott, WA, Snider, AR, Dick, M II, Heidelberger, KP, Bove, EL, Peschiera, AW. Congenital aortic arch thrombosis diagnosed by echocardiography. Am J Cardiol 1987; 59: 485486.CrossRefGoogle ScholarPubMed
14. Conti, VR, Bilfinger, TV, Wolf, W. Aortic arch thrombosis in the neonate. J Thorac Cardiovasc Surg 1988; 95: 138140.CrossRefGoogle ScholarPubMed
15. Hamilton, RM, Penkoske, PA, Byrne, P, Duncan, NF. Spontaneous aortic thrombosis in a neonate presenting as coarctation. Ann Thorac Surg 1988; 45: 564565.CrossRefGoogle Scholar
16. Pilossoff, W, Schöber, JG, Müller, KD, Schumacher, G, Sebening, W, Babic, R. Complete thrombotic obliteration of the ascending aorta and the aortic arch as a cause of acute heart failure in a newborn. Eur J Pediatr 1988; 148: 1114.CrossRefGoogle ScholarPubMed
17. Uva, MS, Serraf, A, Lacour-Gayet, F, et al. Aortic arch thrombosis in the neonate. Ann Thorac Surg 1993; 55: 990992.CrossRefGoogle ScholarPubMed
18. Evans, DJ, Pizer, BL, Moghal, NE, Joffe, HS. Neonatal aortic arch thrombosis. Arch Dis Child 1994; 71: F125F127.CrossRefGoogle ScholarPubMed
19. Zeevi, B, Berant, M. Images in cardiology. Spontaneous aortic arch thrombosis in a neonate. Heart 1999; 81: 560.CrossRefGoogle ScholarPubMed
20. Lanari, M, Lazzarotto, T, Papa, I, et al. Neonatal aortic arch thrombosis as a result of congenital cytomegalovirus infection. Pediatrics 2001; 108: E114.CrossRefGoogle ScholarPubMed
21. Dua, J, Suresh, S, Wilson, D. An unusual case of aortic obstruction. Images Paediatr Cardiol 2004; 6: 1114.Google ScholarPubMed
22. Sharathkumar, AA, Lamear, N, Pipe, S, et al. Management of neonatal aortic arch thrombosis with low-molecular weight heparin: a case series. J Pediatr Hematol Oncol 2009; 31: 516521.CrossRefGoogle ScholarPubMed

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