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Morphology of atrioventricular septal defect and fetal hydrops in the fetal rat

Published online by Cambridge University Press:  19 August 2008

Kazuo Momma  and
Masahiko Ando
Kazuo Momma*
Affiliation:
From the Department of Pediatric Cardiology, Heart Institute of Japan, Tokyo Women's Medical College, Tokyo
Masahiko Ando
Affiliation:
From the Department of Pediatric Cardiology, Heart Institute of Japan, Tokyo Women's Medical College, Tokyo
*
Dr. Kazuo Momma, The Heart Institute of Japan, Tokyo Women's Medical College, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162, Japan. Tel. 03-3353-8111; Fax. 03-3356-0441.
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Abstract

We studied 28 fetal rats with atrioventricular septal defect with a common orifice produced from 300 fetuses treated with bis-diamine (200mg) on the ninth and tenth day of pregnancy. After undergoing rapid whole- body freezing on the 21st day, they were studied by means of serial cross-sectional photographs of the frozen thorax. Forty-one fetuses with normal hearts subsequent to treatment with bis-diamine served as controls. Atrioventricular septal defect was isolated in three, or was associated with either tetralogy of Fallot (n=14) or common arterial trunk (n=11). Fetal hydrops was associated with evidence of regurgitation of the atrioventricular valves. In a subgroup with larger right atrial volumes (increased by more than two standard deviation over the mean in the controls), the following parameters were significantly increased: subcutaneous edema, pericardial effusion, thickening of the left atrioventricular valve, cardiac chamber volumes and masses. The superior and inferior caval veins, and the descending aorta were significantly smaller in fetuses with atrioventricular septal defect than in controls. Fetal atrioventricular septal defect, therefore, was associated frequently with hydrops and increased volumes of the right atrium and both ventricles. Hydropic changes included cutaneous edema and increased pericardial, pleural, and peritoneal fluid.

Type
Original Articles
Information
Cardiology in the Young , Volume 3 , Issue 1 , January 1993 , pp. 13 - 19
Copyright
Copyright © Cambridge University Press 1993

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References

Anderson, RH, Macartney, FJ, Shinebourne, EA, Tynan, M (eds). Paediatric Cardiology. Churchill Livingstone, Edinburgh, 1987, pp 571–614.Google Scholar
Silverman, NH, Kleinman, CS, Rudolph, AM, Copel, JA, Weinstein, EM, Enderlein, MA, Golbus, M.Fetal atrioventricular valve insufficiency associated with nonimmune hydrops: A two dimensional and pulsed Doppler ultrasound study. Circulation 1985; 72: 825–832.CrossRefGoogle ScholarPubMed
Machado, MVL, Crawford, DC, Anderson, RH, Allan, LD.Atrioventricular septal defect detected in prenatal life. Br Heart J 1988; 59: 352–355.CrossRefGoogle ScholarPubMed
Cook, AC, Allan, LD, Anderson, RH, Sharland, G, Fagg, NLK.Atrioventricular septal defect in fetal life—a clinicoparhological correlation. Cardiol Young 1991; 1: 334–343.CrossRefGoogle Scholar
Taleporos, P, Salgo, MP, Oster, G.Teratogenic action of a bis(dichloroacetyl) diamine on rats: patterns of malformations produced in high incidence at timelimited period of development. Teratology 1978; 18: 5–16.CrossRefGoogle ScholarPubMed
Okamoto, N, Sato, Y, Lee, JY, Sumida, H, Hayakawa, K, Ohdo, S, Okishima, T. Morphology and pathogenesis of the cardiovascular anomalies induced by bis-(dichloroaceryl) diamine in rats. In: Nora, JJ, Takao, A (eds). Congenital Heart Disease. Causes and Processes. Futura Publishing Company, Mount Kisco, New York, 1984, pp 199–221.Google Scholar
Momma, K, Takao, A, Ito, R, Nishikawa, T.In situ morphology of the heart and0 great vessels in fetal and neonatal rats. Pediatr Res 1987; 22: 573–580.CrossRefGoogle Scholar
Momma, K, Takao, A.Right ventricular concentric hypertrophy and left ventricular dilatation by ductal constriction in fetal rats. Circ Res 1989; 64: 1137–1146.CrossRefGoogle ScholarPubMed
Momma, K, Ando, M, Takao, A.Fetal cardiac morphology of tetralogy of Fallot with absent pulmonary valve in the rat. Circulation 1990; 82: 1343–1351.CrossRefGoogle ScholarPubMed
Momma, K, Ando, M, Takao, A, Wu, FF.Fetal cardiovascular cross-sectional morphology of tetralogy of Fallot in rats. Fetal Diagn Ther 1990; 5: 196–204.CrossRefGoogle ScholarPubMed
Momma, K, Ando, M, Takao, A, Miyagawa-Tomita, S.Fetal cardiovascular morphology of truncus arteriosus with or without truncal valve insufficiency in the rat. Circulation 1991; 83: 2094–2100.CrossRefGoogle ScholarPubMed
Binder, M.The teratogenic effects of a bis (dichloroacetyl) diamine on hamster embryos. Am J Pathol 1985; 118: 179–183.Google ScholarPubMed
Porter, JF, Schmidt, RR.Developmental toxicity of N, N-bis (dichloroacetyl)- 1,8-octamethylene diamine; effects of in utero exposure on the post-natal murine immune system. Biol Neonate 1986; 50: 221–230.CrossRefGoogle Scholar
Kirby, ML.Cardiac morphogenesis-recent research advances. Pediatr Res 1987; 21: 219–224.CrossRefGoogle ScholarPubMed
Kirby, ML, Waldo, KL.Role of neural crest in congenital heart disease. Circulation 1990; 82: 332–340.CrossRefGoogle ScholarPubMed
Chin, AJ, Keane, JF, Norwood, WI, Castañeda, AR.Repair of complete common atriovenrricular canal in infancy. J Thorac Cardiovas Surg 1982; 84: 437–445.CrossRefGoogle ScholarPubMed
Thanopoulos, BD, Fisher, EA, DuBrow, IW, Hastreiter, AR.Right and left ventricular volume characteristics in common atrioventricular canal. Circulation 1978; 57: 991–995.CrossRefGoogle ScholarPubMed
Jarmakani, JM, George, B, Wheller, J.Ventricular volume characteristics in infants and children with endocardial cushion defects. Circulation 1978; 58: 153–157.CrossRefGoogle ScholarPubMed