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Mesalamine-induced myopericarditis in a paediatric patient with Crohn’s disease

Published online by Cambridge University Press:  10 June 2014

Asha G. Nair Open the ORCID record for Asha G. Nair [Opens in a new window]  and
Russell R. Cross
Asha G. Nair*
Affiliation:
Division of Cardiology, Children’s National Medical Center, Washington, District of Columbia, United States of America
Russell R. Cross
Affiliation:
Division of Cardiology, Children’s National Medical Center, Washington, District of Columbia, United States of America
*
Correspondence to: Dr A. G. Nair, MD, Children’s National Medical Center, 111 Michigan Avenue, N.W., Washington, DC 20010, United States of America. Tel: +(202) 476-2020; E-mail: [email protected]
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Abstract

Mesalamine-containing products are considered first-line treatment for inflammatory bowel disease. Myocarditis is recognised as a very rare possible side effect of these medications, but has not often been described in the paediatric population. We present a case of an adolescent with Crohn’s disease who presented with myopericarditis after recent initiation of Pentasa. Once identified as the causative agent, the drug was discontinued, with subsequent normalisation of troponin and improvement of function. This case identifies the importance of prompt evaluation, diagnosis, and treatment of paediatric patients receiving mesalamine-containing medications that present with significant cardiovascular symptoms.

Keywords

MyocarditismesalamineCrohn’s disease
Type
Brief Reports
Information
Cardiology in the Young , Volume 25 , Issue 4 , April 2015 , pp. 783 - 786
Copyright
© Cambridge University Press 2014 

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