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LV non-compaction in patients with coarctation of the aorta: prevalence and effects on cardiac function

Published online by Cambridge University Press:  26 February 2021

Preeti Choudhary Open the ORCID record for Preeti Choudhary [Opens in a new window] ,
Wendy Strugnell ,
Rajesh Puranik ,
Christian Hamilton-Craig ,
Shelby Kutty Open the ORCID record for Shelby Kutty [Opens in a new window]  and
David S. Celermajer
Preeti Choudhary*
Affiliation:
Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia Faculty of Medicine, University of Sydney, Sydney, Australia
Wendy Strugnell
Affiliation:
Richard Slaughter Centre of Excellence in Cardiovascular Magnetic Resonance Imaging, The Prince Charles Hospital, Brisbane, Australia
Rajesh Puranik
Affiliation:
Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia Faculty of Medicine, University of Sydney, Sydney, Australia
Christian Hamilton-Craig
Affiliation:
Richard Slaughter Centre of Excellence in Cardiovascular Magnetic Resonance Imaging, The Prince Charles Hospital, Brisbane, Australia
Shelby Kutty
Affiliation:
Department of Cardiology, University of Nebraska Medical Center, Omaha, NE, USA
David S. Celermajer
Affiliation:
Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia Faculty of Medicine, University of Sydney, Sydney, Australia
*
Author for correspondence: Dr P. Choudhary, BSc (Medicine), MBBS (Hons I) PhD FRACP, Department of Cardiology, Westmead Hospital, Westmead, New South Wales2145, Australia. Tel: +612 88905555; Fax: +61 296870042. E-mail: [email protected]
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Abstract

Background:

Left ventricular non-compaction has been associated with heart failure, arrhythmia, thromboembolism and sudden death. The prevalence of non-compaction in patients with coarctation of the aorta and its clinical significance remains unknown, although obstructive left heart disease is common in patients with non-compaction. We sought to evaluate the prevalence of left ventricular non-compaction in patients with repaired aortic coarctation as well as its effect on left ventricular size and systolic function.

Methods and results:

In total, 268 patients (Mean age 26 (inter-quartile range 21–37) years, 63% male) undergoing cardiac magnetic resonance imaging for clinical follow-up were included from three tertiary centres for adult congenital heart disease. Clinical data was obtained from medical records and correlated with ventricular volumes and function. Left ventricular non-compaction was defined as a diastolic non-compacted:compacted dimension ratio >2.3 in the worst affected segment on a long-axis view. Left ventricular non-compaction was present in 8.2% of patients with repaired coarctation. Left ventricular end-diastolic volumes and stroke volumes were significantly higher in patients with non-compaction compared to those without. There were no significant differences in ventricular mass or ejection fraction in these two groups.

Conclusions:

Left ventricular non-compaction is relatively common in patients with repaired coarctation of the aorta and correlates with increased left ventricular end-diastolic volumes.

Keywords

Coarctation of aortaleft ventricular non-compactionheart failure
Type
Original Article
Information
Cardiology in the Young , Volume 31 , Issue 9 , September 2021 , pp. 1445 - 1450
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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