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Ketorolac-associated renal morbidity: risk factors in cardiac surgical infants

Published online by Cambridge University Press:  22 October 2012

Brady S. Moffett  and
Antonio Cabrera
Brady S. Moffett*
Affiliation:
Department of Pharmacy, Texas Children's Hospital, Houston, Texas, United States of America
Antonio Cabrera
Affiliation:
Department of Pediatrics, Section of Pediatric Cardiology, Baylor College of Medicine, Houston, Texas, United States of America
*
Correspondence to: Dr B. S. Moffett, PharmD, MPH, Department of Pharmacy, Texas Children's Hospital, 6621 Fannin Street, Suite WB 1120, Houston, Texas 77030, United States of America. Tel: +1 832 824 6087; Fax: +1 832 825 5261; E-mail: [email protected]
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Abstract

We aimed to identify the risk factors for acute kidney injury in infants who have received ketorolac after a cardiac surgical procedure by identifying patients with a ≥50% increase in serum creatinine from baseline and matching them by age with three controls that had <50% increase in serum creatinine. Significant differences in primary surgical procedure, baseline serum creatinine, and concomitant aspirin use were noted. We conclude that the concomitant use of aspirin with ketorolac is associated with increased renal morbidity in young post-cardiac surgical infants.

Keywords

Ketorolacacute kidney injuryinfantsneonatescardiac surgery
Type
Brief Reports
Information
Cardiology in the Young , Volume 23 , Issue 5 , October 2013 , pp. 752 - 754
Copyright
Copyright © Cambridge University Press 2012 

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References

1. Moffett, BS, Wann, TI, Carberry, KE, Mott, AR. Safety of ketorolac in neonates and infants after cardiac surgery. Paediatr Anaesth 2006; 16: 424–428.CrossRefGoogle ScholarPubMed
2. Gupta, A, Daggett, C, Ludwick, J, Wells, W, Lewis, A. Ketorolac after congenital heart surgery: does it increase the risk of significant bleeding complications? Paediatr Anaesth 2005; 15: 139–142.CrossRefGoogle ScholarPubMed
3. Gupta, A, Daggett, C, Drant, S, Rivero, N, Lewis, A. Prospective randomized trial of ketorolac after congenital heart surgery. J Cardiothorac Vasc Anesth 2004; 18: 454–457.Google Scholar
4. Papacci, P, De, FG, Iacobucci, T, et al. Use of intravenous ketorolac in the neonate and premature babies. Paediatr Anaesth 2004; 14: 487–492.Google Scholar
5. Dawkins, TN, Barclay, CA, Gardiner, RL, Krawczeski, CD. Safety of intravenous use of ketorolac in infants following cardiothoracic surgery. Cardiol Young 2009; 19: 105–108.CrossRefGoogle ScholarPubMed
6. Inoue, M, Caldarone, CA, Frndova, H, et al. Safety and efficacy of ketorolac in children after cardiac surgery. Intensive Care Med 2009; 35: 1584–1592.Google Scholar
7. Zappitelli, M, Bernier, PL, Saczkowski, RS, et al. A small post-operative rise in serum creatinine predicts acute kidney injury in children undergoing cardiac surgery. Kidney Int 2009; 76: 885–892.Google Scholar
8. Akcan-Arikan, A, Zappitelli, M, Loftis, LL, Washburn, KK, Jefferson, LS, Goldstein, SL. Modified RIFLE criteria in critically ill children with acute kidney injury. Kidney Int 2007; 71: 1028–1035.Google Scholar
9. Moffett, BS, Goldstein, SL, Adusei, M, Kuzin, J, Mohan, P, Mott, AR. Risk factors for postoperative acute kidney injury in pediatric cardiac surgery patients receiving angiotensin-converting enzyme inhibitors. Pediatr Crit Care Med 2011; 12: 555–559.CrossRefGoogle ScholarPubMed
10. Moffett, BS, Goldstein, SL. Acute kidney injury and increasing nephrotoxic-medication exposure in noncritically-ill children. Clin J Am Soc Nephrol 2011; 6: 856–863.CrossRefGoogle ScholarPubMed
11. D'Agati, V. Does aspirin cause acute or chronic renal failure in experimental animals and in humans? Am J Kidney Dis 1996; 28 (Suppl 1): S24–S29.CrossRefGoogle ScholarPubMed