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in vitro experiments and in vivo implants to evaluate a new silicone-based polyurethane material for replacement of small vessels

Published online by Cambridge University Press:  23 September 2005

giorgio soldani ,
massimo bernabei ,
paola losi ,
adrian crucean ,
dante chiappino ,
silvia burchielli  and
fabio bernini
giorgio soldani
Affiliation:
laboratory for biomaterials and graft technology, hospital “g. pasquinucci”, massa, italy
massimo bernabei
Affiliation:
creas cnr cardiochirurgia pediatrica, institute of clinical physiology, c.n.r., hospital “g. pasquinucci”, massa, italy
paola losi
Affiliation:
laboratory for biomaterials and graft technology, hospital “g. pasquinucci”, massa, italy
adrian crucean
Affiliation:
creas cnr cardiochirurgia pediatrica, institute of clinical physiology, c.n.r., hospital “g. pasquinucci”, massa, italy
dante chiappino
Affiliation:
creas cnr cardiochirurgia pediatrica, institute of clinical physiology, c.n.r., hospital “g. pasquinucci”, massa, italy
silvia burchielli
Affiliation:
servizio di patologia sperimentale, institute of clinical physiology, c.n.r., pisa, italy
fabio bernini
Affiliation:
servizio di patologia sperimentale, institute of clinical physiology, c.n.r., pisa, italy
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Abstract

the idea underscoring our proposed development is to take advantage of the good properties of both polyurethanes (pu) and silicones (pdms). the attributes which make polyurethanes attractive as materials for biomedical applications are their excellent physical–chemical properties, and their relatively good biocompatibility. against their use is the phenomenon of biodegradation that occurs after long-term implantation. silicones, on the other end, are known to have long-term biostability and good haemocompatibility subsequent to their use in several biomedical settings.

Keywords

polyurethanesiliconebiocompatibilityblood compatibilitypig implantsheep implant
Type
original article
Information
Cardiology in the Young , Volume 14 , Issue S3 , October 2004 , pp. 20 - 23
Copyright
2004 cambridge university press

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