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Global Leadership in Paediatric and Congenital Cardiac Care: “Using data to improve outcomes – an interview with Jennifer S. Li, MD, MHS”

Part of: CTY Global Leadership in Paediatric and Congenital Cardiac Care

Published online by Cambridge University Press:  14 September 2020

Justin T. Tretter  and
Jeffrey P. Jacobs
Justin T. Tretter
Affiliation:
The Heart Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Jeffrey P. Jacobs
Affiliation:
Congenital Heart Center, UF Health Shands Children’s Hospital, Gainesville, FL, USA Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Florida, Gainesville, FL, USA Cardiology in the Young, Cambridge, UK
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Abstract

Dr. Jennifer Li is the focus of our second in a planned series of interviews in Cardiology in the Young entitled, “Global Leadership in Paediatric and Congenital Cardiac Care”. Dr. Li was born in Boston, Massachusetts, United States of America, and moved to Indianapolis, Indiana where she completed her secondary education. She then attended Stanford University, majoring in Chemistry and English and graduating with distinction in 1983. Dr. Li then attended Duke University School of Medicine, graduating in 1987. She then completed her internship at Children’s Hospital of Philadelphia in 1987–1989, returning to Duke University Medical Center to complete both her residency in general paediatrics in 1989–1990 followed by her fellowship in paediatric cardiology in 1990–1993. She would later complete her Master’s Degree in Health Sciences at Duke University in 2005.

Dr. Li has spent her entire career as a paediatric cardiologist at Duke University Medical Center, where she was appointed a Professor of Pediatrics and Professor of Medicine in 2008 and has held the position as Beverly C. Morgan Endowed Professor of Pediatrics since 2012. She has served as the Chief of Paediatric Cardiology at Duke University Medical Center since 2006. She also was the Director of Paediatric Research at Duke Clinical Research Institute from 2001-2015. Dr. Li has played an instrumental role in evaluating the safety and efficacy of drugs in children, as well as in analysing and linking large multicentric databases to evaluate the outcomes, quality, and cost of paediatric and congenital cardiac care. Dr. Li has received funding from the National Institute of Health of the United States of America, as well as from industry and foundation grants. This article presents our interview with Dr. Li, an interview that covers her experience collaborating with governmental organizations and industry in the pursuit of common interests to design clinical drug trials, link and analyse large, multicentric databases, and improve paediatric health care.

Type
Interview
Information
Cardiology in the Young , Volume 30 , Issue 9 , September 2020 , pp. 1226 - 1230
Copyright
© The Author(s), 2020. Published by Cambridge University Press

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References

Krasinski, K, Perkin, R, Rutledge, J.Gray baby syndrome revisited. Clin Pediatr (Phila) 1982;21:571–572.CrossRefGoogle ScholarPubMed
Speirs, AL.Thalidomide and congenital abnormalities. Lancet 1962;1:303–305.CrossRefGoogle ScholarPubMed
Food and Drug Administration Modernization Act of 1997. (Accessed August 11, 2020, at https://www.congress.gov/bill/105th-congress/senate-bill/830/text?q=%7B%22search%22%3A%22Pediatric+Exclusivity+Act%22%7D&s=6&r=2&overview=closed.)Google Scholar
Benjamin, DK Jr., Smith, PB, Murphy, MD, et al.Peer-reviewed publication of clinical trials completed for pediatric exclusivity. JAMA 2006;296:1266–1273.CrossRefGoogle ScholarPubMed
Best Pharmaceuticals for Children Act. (Accessed August 11, 2020, at https://www.congress.gov/congressional-report/107th-congress/senate-report/79/1.)Google Scholar
Li, JS, Eisenstein, EL, Grabowski, HG, et al.Is pediatric exclusivity working? Pediatric Health 2007;1:43–49.CrossRefGoogle Scholar
Smith, PB, Benjamin, DK Jr, Murphy, MD, et al.Safety monitoring of drugs receiving pediatric marketing exclusivity. Pediatrics 2008;122:e628–e633.CrossRefGoogle ScholarPubMed
Curzon, CL, Milford-Beland, S, Li, JS, et al.Cardiac surgery in infants with low birth weight is associated with increased mortality: analysis of the Society of Thoracic Surgeons Congenital Heart Database. J Thorac Cardiovasc Surg 2008;135:546–551.CrossRefGoogle Scholar
Pasquali, SK, Hall, M, Li, JS, et al.Safety of aprotinin in congenital heart operations: results from a large multicenter database. Ann Thorac Surg 2010;90:14–21.CrossRefGoogle ScholarPubMed
Barker, GM, O’Brien, SM, Welke, KF, et al.Major infection after pediatric cardiac surgery: a risk estimation model. Ann Thorac Surg 2010;89:843–850.CrossRefGoogle ScholarPubMed
Johnson, JN, Jaggers, J, Li, S, et al.Center variation and outcomes associated with delayed sternal closure after stage 1 palliation for hypoplastic left heart syndrome. J Thorac Cardiovasc Surg 2010;139:1205–1210.CrossRefGoogle ScholarPubMed
Fudge, JC Jr, Li, S, Jaggers, J, et al.Congenital heart surgery outcomes in Down syndrome: analysis of a national clinical database. Pediatrics 2010;126:315–322.CrossRefGoogle ScholarPubMed
Wallace, MC, Jaggers, J, Li, JS, et al.Center variation in patient age and weight at Fontan operation and impact on postoperative outcomes. Ann Thorac Surg 2011;91:1445–1452.CrossRefGoogle ScholarPubMed
Burstein, DS, Jacobs, JP, Li, JS, et al.Care models and associated outcomes in congenital heart surgery. Pediatrics 2011;127:e1482–e1489.CrossRefGoogle ScholarPubMed
Hornik, CP, He, X, Jacobs, JP, et al.Complications after the Norwood operation: an analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database. Ann Thorac Surg 2011;92:1734–1740.CrossRefGoogle Scholar
Pasquali, SK, Li, JS, Burstein, DS, et al.Association of center volume with mortality and complications in pediatric heart surgery. Pediatrics 2012;129:e370–e376.CrossRefGoogle ScholarPubMed
Hill, KD, Baldwin, HS, Bichel, DP, et al.Rationale and design of the STeroids to REduce Systemic inflammation after infant heart Surgery (STRESS) trial. Am Heart J 2020;220:192–202.CrossRefGoogle ScholarPubMed
Pasquali, SK, Jacobs, JP, Shook, GJ, et al.Linking clinical registry data with administrative data using indirect identifiers: implementation and validation in the congenital heart surgery population. Am Heart J 2010;160:1099–1104.CrossRefGoogle ScholarPubMed
Pasqual, SK, Li, JS, Jacobs, ML, Shah, SS, Jacobs, JP.Opportunities and challenges in linking information across databases in pediatric cardiovascular medicine. Prog Pediatr Cardiol 2012;33:21–24.CrossRefGoogle ScholarPubMed
Pasquali, SK, Li, JS, He, X, et al.Perioperative methylprednisolone and outcome in neonates undergoing heart surgery. Pediatrics 2012;129:e385–e391.CrossRefGoogle ScholarPubMed
Pasquali, SK, Li, JS, He, X, et al.Comparative analysis of antifibrinolytic medications in pediatric heart surgery. J Thorac Cardiovasc Surg 2012;143:550–557.CrossRefGoogle ScholarPubMed
Pasquali, SK, Peterson, ED, Jacobs, JP, et al.Differential case ascertainment in clinical registry versus administrative data and impact on outcomes assessment for pediatric cardiac operations. Ann Thorac Surg 2013;95:197–203.CrossRefGoogle ScholarPubMed
Pasquali, SK, He, X, Jacobs, ML, et al.Hospital variation in postoperative infection and outcome after congenital heart surgery. Ann Thorac Surg 2013;96:657–663.CrossRefGoogle ScholarPubMed
Pasquali, SK, Jacobs, ML, He, X, et al.Variation in congenital heart surgery costs across hospitals. Pediatrics 2014;133:e553–e560.CrossRefGoogle ScholarPubMed
Pasquali, SK, He, X, Jacobs, ML, et al.Excess costs associated with complications and prolonged length of stay after congenital heart surgery. Ann Thorac Surg 2014;98:1660–1666.CrossRefGoogle ScholarPubMed
Newburger, JW, Sleeper, LA, Bellinger, DC, et al.Early developmental outcome in children with hypoplastic left heart syndrome and related anomalies: the single ventricle reconstruction trial. Circulation 2012;125:2081–2091.CrossRefGoogle ScholarPubMed
Tweddell, JS, Sleeper, LA, Ohye, RG, et al.Intermediate-term mortality and cardiac transplantation in infants with single-ventricle lesions: risk factors and their interaction with shunt type. J Thorac Cardiovasc Surg 2012;144:152–159.CrossRefGoogle ScholarPubMed
Plummer, ST, Hornik, CP, Baker, H, et al.Maladaptive aortic properties after the Norwood procedure: An angiographic analysis of the Pediatric Heart Network Single Ventricle Reconstruction Trial. J Thorac Cardiovasc Surg 2016;152:471–479.e3.CrossRefGoogle ScholarPubMed
Newburger, JW, Sleeper, LA, Gaynor, JW, et al.Transplant-Free Survival and Interventions at 6 Years in the SVR Trial. Circulation 2018;137:2246–2253.CrossRefGoogle ScholarPubMed
Goldberg, CS, Hu, C, Brosig, C, et al.Behavior and Quality of Life at 6 Years for Children With Hypoplastic Left Heart Syndrome. Pediatrics 2019;144.Google ScholarPubMed
Li, JS, Sexton, DJ, Mick, N, et al.Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis 2000;30:633–638.CrossRefGoogle Scholar