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A case of neonatal myocardial infarction: left coronary artery thrombus resolution and normalisation of ventricular function by intracoronary low-dose tissue plasminogen activator

Published online by Cambridge University Press:  17 July 2014

Anna Hallbergson ,
Matthew J. Gillespie  and
Yoav Dori
Anna Hallbergson*
Affiliation:
Division of Cardiology, The Children’s Hospital of Philadelphia, Perelman School of Medicine and the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Matthew J. Gillespie
Affiliation:
Division of Cardiology, The Children’s Hospital of Philadelphia, Perelman School of Medicine and the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Yoav Dori
Affiliation:
Division of Cardiology, The Children’s Hospital of Philadelphia, Perelman School of Medicine and the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
*
Correspondence to: A. Hallbergson, MD, PhD, Division of Cardiology, Children’s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, United States of America. Tel: +215 590 1790; Fax: +215 590 5415; E-mail: [email protected]
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Abstract

Neonatal myocardial infarction is a rare clinical entity that is associated with high mortality. Reported treatment strategies include supportive care, extracorporeal membrane oxygenation, thrombolytics, and surgical thrombectomy. Herein we report a neonate who developed an acute myocardial infarction owing to a thrombus in the proximal left coronary artery. At 24 hours of life, he was treated with local (intracoronary) thrombolytic therapy at a lower dose than previously reported, as well as with systemic anticoagulation. There was subsequent angiographic resolution of the thrombus and normalisation of left ventricular function.

Keywords

Neonatal myocardial infarctioninterventional cardiologythrombolytics
Type
Brief Reports
Information
Cardiology in the Young , Volume 25 , Supplement 4 , April 2015 , pp. 810 - 812
Copyright
© Cambridge University Press 2014 

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References

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