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Cardiac function in children with premature ventricular contractions: the effect of omega-3 polyunsaturated fatty acid supplementation

Published online by Cambridge University Press:  15 May 2018

Taliha Oner ,
Rahmi Ozdemir ,
Onder Doksöz ,
Dildar B. Genc ,
Baris Guven ,
Savas Demirpence ,
Murat M. Yilmazer ,
Yilmaz Yozgat ,
Timur Mese  and
Vedide Tavli
Taliha Oner*
Affiliation:
SisliEtfal Training and Research Hospital, Department of Pediatric Cardiology, Sisli, Istanbul, Turkey
Rahmi Ozdemir
Affiliation:
Dr. Behçet Uz Children’s Hospital, Department of Pediatric Cardiology, Alsancak, Izmir, Turkey
Onder Doksöz
Affiliation:
Dr. Behçet Uz Children’s Hospital, Department of Pediatric Cardiology, Alsancak, Izmir, Turkey
Dildar B. Genc
Affiliation:
Sisli EtfalTraining and Research Hospital, Department of Pediatric Oncology, Sisli, Istanbul, Turkey
Baris Guven
Affiliation:
Dr. Behçet Uz Children’s Hospital, Department of Pediatric Cardiology, Alsancak, Izmir, Turkey
Savas Demirpence
Affiliation:
Sifa University, Faculty of Medicine, Department of Pediatric Cardiology, Bornova, Izmir, Turkey
Murat M. Yilmazer
Affiliation:
Dr. Behçet Uz Children’s Hospital, Department of Pediatric Cardiology, Alsancak, Izmir, Turkey
Yilmaz Yozgat
Affiliation:
Dr. Behçet Uz Children’s Hospital, Department of Pediatric Cardiology, Alsancak, Izmir, Turkey
Timur Mese
Affiliation:
Dr. Behçet Uz Children’s Hospital, Department of Pediatric Cardiology, Alsancak, Izmir, Turkey
Vedide Tavli
Affiliation:
Sifa University, Faculty of Medicine, Department of Pediatric Cardiology, Bornova, Izmir, Turkey
*
Author for correspondence: T. Oner, MD, SisliEtfalTraining and Research Hospital, Department of Pediatric Cardiology, Sisli, 34360 Istanbul, Turkey. Tel: +00 90 212 373 50 00; Fax: +0 212 234 11 21; E-mail: [email protected]
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Abstract

Background

Premature ventricular contractions are accepted as benign in structurally normal hearts. However, reversible cardiomyopathy can sometimes develop. Omega-3 polyunsaturated fatty acids have anti-arrhythmic properties in animals and humans.

Aim

We evaluated left ventricular function in children with premature ventricular contractions with normal cardiac anatomy and assessed the impact of omega-3 fatty acid supplementation on left ventricular function in a prospective trial.

Methods

A total of 25 patients with premature ventricular contraction, with more than 2% premature ventricular contractions on 24-hour Holter electrocardiography, and 30 healthy patients were included into study. All patients underwent electrocardiography, left ventricular M-mode echocardiography, and myocardial performance index testing. Patients with premature ventricular contraction were given omega-3 fatty acids at a dose of 1 g/day for 3 months, and control echocardiography and 24-hour Holter electrocardiography were performed. Neither placebo nor omega-3 fatty acids were given to the control group.

Results

Compared with the values of the control group, the patients with premature ventricular contraction had significantly lower fractional shortening. The myocardial performance index decreased markedly in the patient groups. The mean heart rate and mean premature ventricular contraction percentage of Group 2 significantly decreased in comparison with their baseline values after the omega-3 supplementation.

Conclusion

In conclusion, premature ventricular contractions can lead to systolic cardiac dysfunction in children. Omega-3 supplementation may improve cardiac function in children with premature ventricular contractions. This is the first study conducted in children to investigate the possible role of omega-3 fatty acid supplementation on treatment of premature ventricular contractions.

Keywords

Premature ventricular contractionsomega-3 PUFAcardiac functionchildren
Type
Original Articles
Information
Cardiology in the Young , Volume 28 , Issue 7 , July 2018 , pp. 949 - 954
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Copyright
© Cambridge University Press 2018 

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