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Liver Polyploidy in Alzheimer's Disease

Published online by Cambridge University Press:  29 November 2010

M. Fisman ,
M.I. Laskey  and
H.E. Enesco
M. Fisman
Affiliation:
London Psychiatric Hospital
M.I. Laskey
Affiliation:
Concordia University.
H.E. Enesco
Affiliation:
Concordia University.
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Abstract

The amount of liver polyploidy in a group of patients with Alzheimer's disease (AD) was compared with that of an age-matched control group. There was great variability in the percentage of cells in each ploidy class from one individual to the next in both control and AD subjects. AD patients had a lower percentage of 2N cells, and a higher percentage of 4N cells than the controls. There was no difference in the percentage of 8N or 16N cells in AD, indicating that there was no shift to higher ploidy classes in AD. The most stringent statistical analysis failed to reveal statistically significant differences between the AD and control groups.

Résumé

Un nombre de noyaux hépatiques polyploides ont été étudiés chez des personnes humaines agées témoins et chez des malades affligés de la maladie d'Alzheimer (MA). On a trouvé une grande variabilité du degré de poly ploidie chez les individus de chaques groupes. Chez les MA, le pourcentage de noyaux 2N est plus bas tandis que celui des 4N est plus élevé. Par contre, on n'a pas décelé de différence entre les groupes pour la fréquence des noyaux 8N et 16N suggérant qu'il n'y a pas de tendance vers une élévation de polyploidie chez les MA. Une analyse statistique des plus rigoureuse ne démontre pas de différence significative dans la distribution de types de noyaux chez les deux groupes.

Keywords

liver polyploidyAlzheimer's Disease
Type
Articles
Information
Canadian Journal on Aging / La Revue canadienne du vieillissement , Volume 6 , Issue 4 , Winter/Hiver 1987 , pp. 264 - 270
Copyright
Copyright © Canadian Association on Gerontology 1987

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