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Hexose Transport and Metabolism in Cultured Fibroblasts Derived from Normal and Alzheimer Disease Affected Individuals

Published online by Cambridge University Press:  29 November 2010

Ralph J. Germinario ,
Zully Chang  and
Maureen Oliveira
Ralph J. Germinario
Affiliation:
Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital.
Zully Chang
Affiliation:
Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital.
Maureen Oliveira
Affiliation:
Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital.
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Abstract

The transport and metabolism of glucose was compared in cultured skin fibroblasts derived from normal and Alzheimer disease affected individuals. No significant differences were observed in sugar transport, CO2 production, lactate production, trichloroacetic acid soluble and precipitable material between the test groups. It is concluded that altered glucose uptake or metabolism is not a general characteristic of all Alzheimer disease cultured fibroblasts.

Résumé

Le transpon et le métabolisme du glucose ont été comparés dans des fibroblastes en culture dérivés d'individus normaux et des personnes affectées par la maladie d'Alzheimer. Il n'y avait pas de différence significative dans le transport des glucides, dans la production de gaz carbonique et de lactate. De plus, aucune variation entre les deux groupes n'a été constatée dans chacune des fractions: solubles on TCA précipitables. En conclusion, les différences constatées aussi bien au niveau de l'incorporation de glucose que dans le métabolisme ne sont pas une caractéristique de fibroblastes issus de personnes atteintes de la maladie d'Alzheimer.

Keywords

Alzheimer's diseaseglucose metabolismcell culturehuman fibroblasts
Type
Articles
Information
Canadian Journal on Aging / La Revue canadienne du vieillissement , Volume 8 , Issue 3 , Fall/automne 1989 , pp. 286 - 294
Copyright
Copyright © Canadian Association on Gerontology 1989

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