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The Syrian Golden Hamster: A Model for the Cardiomyopathy of Friedreich's Ataxia

Published online by Cambridge University Press:  18 September 2015

J. Azari ,
T. Reisine ,
A. Barbeau ,
H.I. Yamamura  and
R. Huxtable
J. Azari
Affiliation:
Department of Pharmacology, University of Arizona Health Sciences Center, Tucson and the Department of Neurobiology, Clinical Research Institute of Montreal
T. Reisine
Affiliation:
Department of Pharmacology, University of Arizona Health Sciences Center, Tucson and the Department of Neurobiology, Clinical Research Institute of Montreal
A. Barbeau
Affiliation:
Department of Pharmacology, University of Arizona Health Sciences Center, Tucson and the Department of Neurobiology, Clinical Research Institute of Montreal
H.I. Yamamura
Affiliation:
Department of Pharmacology, University of Arizona Health Sciences Center, Tucson and the Department of Neurobiology, Clinical Research Institute of Montreal
R. Huxtable
Affiliation:
Department of Pharmacology, University of Arizona Health Sciences Center, Tucson and the Department of Neurobiology, Clinical Research Institute of Montreal
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Summary

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In light of the available information on the cardiomyopathy of Friedreich's ataxia, the cardiomyopathic Syrian hamster may be an appropriate laboratory model. Cardiomyopathy in these animals is a result of calcium accumulation. We analyzed the atria and right and left ventricles from cardiomyopathic (CM) and random bred (RB) animals for calcium, magnesium, and iron concentrations at 30-40 and 60-70 days of age (age of maximum lesioning). There are no significant differences in the concentration of iron or magnesium among age-matched groups. The concentration of calcium in the left ventricles of the CM animals at 60 days old is 14 fold higher than that of R B animals. Although there is a significant difference in the concentration of calcium in the left ventricles of younger animals, it is not as pronounced as the difference in older animals. Analysis of the taurine concentration in 30-40 day old animals revealed that the CM animals show slightly higher taurine concentrations than RB in the whole heart. In 60 day old CM hamsters the ß-adrenergic receptor density of the ventricles is unchanged. This indicates that calcium overload is not due to a drene rg i c super sensitivity.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 6 , Issue 2 , May 1979 , pp. 223 - 226
Copyright
Copyright © Canadian Neurological Sciences Federation 1979

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