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Single Photon Emission Computed Tomography Using 99mTc-HM-PAO in the Routine Evaluation of Alzheimer's Disease

Published online by Cambridge University Press:  18 September 2015

T.A. Hurwitz ,
W. Ammann ,
D. Chu ,
C. Clark ,
J. Holden  and
R. Brownstone
T.A. Hurwitz*
Affiliation:
Department of Psychiatry, University of British Columbia
W. Ammann
Affiliation:
Department of Nuclear Medicine, University of British Columbia
D. Chu
Affiliation:
Department of Nuclear Medicine, University of British Columbia
C. Clark
Affiliation:
Department of Psychiatry, University of British Columbia
J. Holden
Affiliation:
Department of Pathology, University of British Columbia
R. Brownstone
Affiliation:
Department of Physiology, University of Manitoba
*
Department of Psychiatry, University Hospital, UBC Site, 2255 Wesbrook Mall, Vancouver, B.C., Canada V6T 2A1
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Abstract:

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Regional cerebral blood flow was studied in 7 patients with clinically suspected Alzheimer's disease and 10 normal controls by single photon computed emission tomography (SPECT) using HM-PAO. All patients with Alzheimer's disease and no controls had parietal lobe hypoperfusion which was usually bilateral. In patients with more severe dementia hypoperfusion extended into the frontal lobes. Parietal lobe hypoperfusion corresponds to parietal lobe degeneration which is the one of the first neocortical regions to show the typical degenerative changes of Alzheimer's disease. SPECT with HM-PAO is a non-invasive investigation available in most nuclear medicine departments and complements existing tests in the routine evaluation of patients presenting with dementia.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue 1 , February 1991 , pp. 59 - 62
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

References

1.Brun, A, Englund, E.Regional pattern of degeneration of Alzheimer’s disease: Neuronal loss and histopathological grading. Histopathology 1981; 5: 549–564.CrossRefGoogle ScholarPubMed
2.McGeer, PL, Kamo, H, Harrop, R, et al. Positron emission tomography in patients with clinically diagnosed Alzheimer’s disease. Can Med Assoc J 1986; 134: 597–607.Google ScholarPubMed
3.Chase, TN, Foster, NL, Fedio, P, et al. Regional cortical dysfunction in Alzheimer’s disease as determined by positron emission tomography. Ann of Neurol 1984; 15: S170–S174.Google ScholarPubMed
4.Cutler, NR, Haxby, JV, Duara, R, et al. Brain metabolism as measured with positron emission tomography: Serial assessment in a patient with familial Alzheimer’s disease. Neurology 1985; 35: 1556–1561.CrossRefGoogle Scholar
5.Duara, R, Grady, C, Haxby, J, et al. Positron emission tomography in Alzheimer’s disease. Neurology 1986; 36: 879–887.CrossRefGoogle ScholarPubMed
6.Baron, JC, LeBrun-Grandie, PH, Collard, PH, et al. Noninvasive measurement of blood flow, oxygen consumption, and glucose utilization in the same brain regions in man by positron emission tomography: Concise communication. J Nucl Med 1982; 23: 391–399.Google Scholar
7.Kuschinsky, W, Suda, S, Sokoloff, L.Local cerebral glucose utilization and blood flow during metabolic acidosis. Am J Physiol 1981; 241: 772–777.Google ScholarPubMed
8.Ell, PJ, Jarritt, PH, Costa, DC, et al. Functional imaging of the brain. Semin Nuc Med 1987; 17: 214–299.CrossRefGoogle ScholarPubMed
9.American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-III-R) 3rd ed - revised. Washington DC: American Psychiatric Association, 1987.Google Scholar
10.Folstein, MF, Folstein, SE, McHugh, PR.“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189–198.CrossRefGoogle ScholarPubMed
11.Hughes, CP, Berg, L, Danziger, WL, et al. A new clinical scale for the staging of dementia. Br J Psychiatry 1982; 140: 566–572.CrossRefGoogle ScholarPubMed
12.Johnston, KA, Holman, BL, Mueller, SP, et al. Single photon emission computed tomography in Alzheimer’s disease. Arch Neurol 1988; 45: 392–396.CrossRefGoogle Scholar
13.Neary, D, Snowden, JS, Shields, RA, et al. Single photon emission tomography using 99m Tc-HM-PAO in the investigation of dementia. J Neurol Neurosurg Psychiatry 1987; 50: 1101–1109.CrossRefGoogle ScholarPubMed
14.Gemmell, HG, Sharp, PF, Besson, JAO, et al. Differential diagnosis in dementia using the cerebral blood flow agent 99mtc HM-PAO: a SPECT study. J Comput Assist Tomogr 1987; 11 (3): 398–402.CrossRefGoogle ScholarPubMed
15.Perani, D, Di Piero, V, Vallar, G, et al. Technetium - 99m HM-PAOSPECT study of regional cerebral perfusion in early Alzheimer’s disease. J Nucl Med 1988; 29: 1507–1514.Google ScholarPubMed