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Serial Recordings of Multimodality Evoked Potentials in Multiple Sclerosis:A Four Year Follow-Up Study

Published online by Cambridge University Press:  18 September 2015

Vicente J. Iragui ,
Wigbert C. Wiederholt  and
John S. Romine
Vicente J. Iragui*
Affiliation:
Neurology Service, San Diego Veterans Administration Medical Center, Department of Neurosciences, University of California, San Diego, and the Division of Neurology, Scripps Clinic and Research Foundation, La Jolla, California
Wigbert C. Wiederholt
Affiliation:
Neurology Service, San Diego Veterans Administration Medical Center, Department of Neurosciences, University of California, San Diego, and the Division of Neurology, Scripps Clinic and Research Foundation, La Jolla, California
John S. Romine
Affiliation:
Neurology Service, San Diego Veterans Administration Medical Center, Department of Neurosciences, University of California, San Diego, and the Division of Neurology, Scripps Clinic and Research Foundation, La Jolla, California
*
Department of Neurosciences (M-008), University of California, San Diego, La Jolla, CA 92093, U.S.A.
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Abstract:

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Pattern reversal visual, brain-stem auditory, and short latency median nerve somatosensory evoked potentials (EPs) were evaluated in a prospective study over 4 years in 20 patients with clinically definite sclerosis (MS). Standardized neurological examinations were done at regular intervals and correlated with EP findings. The highest incidence of EP abnormalities occurred in the visual system followed by the somatosensory and auditory systems. Clinical relapse was usually accompanied by EP deterioration, but clinical improvement often occurred without parallel EP recovery. EP changes were not always related to clinical symptoms and often took place during remission periods in the absence of clinical changes. There was no significant correlation between clinical and electrophysiological progression within any given sensory modality. The progression of clinical disability, however, showed a fairly good correlation with the overall progression of EP abnormalities. We conclude that EPs complement the neurological exam in the evaluation of MS and may have a place in the investigation of the effects of therapeutic agents on the neurological status in MS.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue 4 , November 1986 , pp. 320 - 326
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

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