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Selective Sparing of Human Nucleus Accumbens in Aging and Anoxia

Published online by Cambridge University Press:  18 September 2015

Ke-Wei Huang  and
Yan Zhao
Ke-Wei Huang*
Affiliation:
Neuropathology Laboratory, Chinese PLA General Hospital, Beijing
Yan Zhao
Affiliation:
Neuropathology Laboratory, Chinese PLA General Hospital, Beijing
*
Neuropathology Laboratory, Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China
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Abstract

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Objective

To investigate the effects of aging and anoxia on the nucleus accumbens.

Methods

The number of neurons in nucleus accumbens and caudate neucleus in 35 patients over 65 and 35 under 65 years, all without neurological or psychiatric diseases were counted.

Results

There was no statistically significant difference between the number of neurons in the accumbens in the two groups, but there was a decrease in the number of neurons in the elderly group. There was no reduction in volume of the neuronal nucleoli of the accumbens measured in 12 elderly patients compared to controls. These data suggest a sparing of the accumbens from changes associated with aging. There was relative preservation of the nucleus accumbens in 3 patients with anoxic encephalopathy.

Conclusions

These results show that accumbens was resistant to both aging and anoxia, the mechanism of which is discussed.

Résumé

Résumé<span class='italic'><span class='bold'>Objectif</span></span>

L’étude porte sur les effets du vieillissement et de l’anoxie sur le noyau accumbens.

<span class='italic'><span class='bold'>Méthode</span></span>

Nous avons dénombré les neurones du noyau accumbens (Ace) et du noyau caudé (NC) chez 35 patients de plus de 65 ans et 35 patients de moins de 65 ans, sans maladie neurologique ou psychiatrique.

<span class='italic'><span class='bold'>Résultats</span></span>

Il n’existait pas de différence significative au point de vue statistique entre le nombre de neurones dans l’Ace entre les deux groupes. Cependant, il y avait une diminution du nombre de neurones dans le NC du groupe âgé. Il n’y avait pas de diminution du volume des nucléoles neu-ronaux de l’Ace chez 12 patients âgés comparés à des contrôles. Ces observations suggèrent une épargne sélective de l’Ace par le vieillissement. Chez 3 patients avec encéphalopathie anoxique, l’Ace était relativement préservé.

<span class='italic'><span class='bold'>Conclusions</span></span>

Ces résultats indiquent que l’Ace est résistant au vieillissement et à l’anoxie, et nous discutons des mécanismes en cause.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 22 , Issue 4 , November 1995 , pp. 290 - 293
Copyright
Copyright © Canadian Neurological Sciences Federation 1995

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