Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-30T14:59:31.907Z Has data issue: false hasContentIssue false
  • English
  • Français

Relationships Between Interictal Spiking and Seizures: Human and Experimental Evidence

Published online by Cambridge University Press:  18 September 2015

Jean Gotman
Jean Gotman*
Affiliation:
Montreal Neurological Institute, and Department of Neurology and Neurosurgery, McGill University, Montréal
*
Montreal Neurological Institute, Neurophysiology Department, 3801 University Street, Montreal, Québec, Canada H3A 2B4
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Epileptic seizures of focal origin often occur unpredictably as do interictal spikes. It is often assumed that spikes increase prior to seizures of focal origin and that antiepileptic medication affects spikes and seizures in a parallel fashion. We review evidence that this assumption is invalid and that there is a clear dissociation between spikes and seizures: increases in spiking before seizures have not been clearly documented; decreases in antiepileptic medication do not result directly in increased spiking; seizures are often followed by long-lasting increases in spiking; finally, seizures are no more likely when spikes are frequent than when spikes are rare. It therefore appears that spikes and seizures are two quite distinct phenomena, both originating in the epileptic focus but varying over time differently from what is most often believed.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue S4 , November 1991 , pp. 573 - 576
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

References

REFERENCES

1.Lange, HH, Lieb, JP, Engel, J Jr, et al. Temporo-spatial patterns of pre-ictal spike activity in human temporal lobe epilepsy. Electro-encephalogr Clin Neurophysiol 1983; 56: 543–555.CrossRefGoogle ScholarPubMed
2.Gotman, J, Marciani, MG.Electroencephalographic spiking activity, drug levels and seizure occurrence in epileptic patients. Ann Neurol 1985; 17: 597–603.CrossRefGoogle ScholarPubMed
3.Ralston, BL.The mechanism of transition of interictal spiking foci into ictal seizure discharges. Electroencephalogr Clin Neurophysiol 1958; 10: 217–232.CrossRefGoogle ScholarPubMed
4.Sherwin, I.Interictal-ictal transition in the feline penicillin epileptogenic focus. Electroencephalogr Clin Neurophysiol 1978; 45: 525–534.CrossRefGoogle ScholarPubMed
5.Wada, JA, Sato, M, Corcoran, ME.Persistent seizure susceptibility and recurrent spontaneous seizures in kindled cats. Epilepsia 1974; 15: 465–478.CrossRefGoogle ScholarPubMed
6.Pinel, JPJ, Rovner, LI.Electrode placement and kindling-induced experimental epilepsy. Exp Neurol 1978; 58: 335–346.CrossRefGoogle ScholarPubMed
7.Gotman, J.Relationships between triggered seizures, spontaneous seizures and interictal spiking in the kindling model of epilepsy. Exp Neurol 1984; 84: 259–273.CrossRefGoogle ScholarPubMed
8.Ajmone-Marsan, C, Zivin , LS.Factors related to the occurrence of typical paroxysmal abnormalities in the EEG records of epileptic patients. Epilepsia 1970; 11: 361–381.CrossRefGoogle Scholar
9.Gotman, J, Ives, JR, Gloor, P, et al. Long-term monitoring at the Montreal Neurological Institute. In: Gotman, J, Ives, JR, Gloor, P, eds. Long-term monitoring in epilepsy. Amsterdam: Elsevier 1985; 215–239.Google ScholarPubMed
10.Gotman, J, Ives, JR, Gloor, P.Automatic recognition of interictal epileptic activity in prolonged EEG recordings. Electroencephalogr Clin Neurophysiol 1979; 46: 510–520.CrossRefGoogle ScholarPubMed
11.Montplaisir, J, Laverdière, M, Saint-Hilaire, JM.Sleep and epilepsy. In: Gotman, J, Ives, JR, Gloor, P, eds. Long-term monitoring in epilepsy. Amsterdam: Elsevier 1985; 215–239.Google ScholarPubMed
12.Gotman, J, Koffler, DJ.Interictal spiking increases after seizures but does not after decrease in medication. Electroencephalogr Clin Neurophysiol 1989; 72: 7–15.CrossRefGoogle Scholar
13.Katz, A, Marks, DA, McCarthy, G, et al. Does interictal spiking change prior to seizures? Electroencephalogr Clin Neurophysiol 1991; 79: 153–156.CrossRefGoogle ScholarPubMed
14.Gigli, GL, Gotman, J.Effects of kindled seizures and carbamazepine on interictal spiking. Epilepsy Res 1991; 8: 204–212.CrossRefGoogle ScholarPubMed
15.Leung, LWS.Spontaneous hippocampal interictal spikes following local kindling: time-course of change and relation to behavioral seizures. Brain Res 1990; 513: 308–314.CrossRefGoogle ScholarPubMed
16.Duncan, JS.Antiepileptic drugs and the electroencephalogram. Epilepsia 1987; 28: 259–266.CrossRefGoogle ScholarPubMed
17.Van, Wieringen, et al. Electroencephalographic findings in antiepileptic drug trials: a review and report of 6 studies. Epilepsy Res 1987; 1: 3–15.Google Scholar
18.Jensen, MS, Yaari, Y.The relationship between interictal and ictal paroxysms in an in-vitro model of focal hippocampal epilepsy. Ann Neurol 1988; 24: 591–598.CrossRefGoogle Scholar
19.Milligan, N, Oxley, J, Richens, A.Acute effect of intravenous pheny- toin on the frequency of interictal spikes in man. Br J Pharmacol 1983; 16: 285–289.CrossRefGoogle Scholar
20.Ahmad, S, Perucca, E, Richens, A.The effect of Frusemide, Mexiletine (+) – Propanolol and three Benzodiazepine drugs on interictal spike discharges in the electroencephalograms of epileptic patients. Br J Clin Pharmacol 1977; 4: 683–688.CrossRefGoogle Scholar