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The Relationship Between Alzheimer's Disease, Parkinson's Disease and Motor Neuron Disease

Published online by Cambridge University Press:  18 September 2015

Donald B. Calne  and
Andrew Eisen
Donald B. Calne*
Affiliation:
Belzberg Laboratory of Clinical Neuroscience and Division of Neurology, Department of Medicine, University Hospital - U.B.C. Site, Vancouver
Andrew Eisen
Affiliation:
Belzberg Laboratory of Clinical Neuroscience and Division of Neurology, Department of Medicine, University Hospital - U.B.C. Site, Vancouver
*
Belzberg Laboratory of Clinical Neuroscience, Division of Neurology, Department of Medicine, University Hospital, U.B.C. Site, 2211 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 1W5
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Abstract:

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We argue against the dominant status assigned to conventional microscopy in the categorization of disorders such as Alzheimer's disease, Parkinson's disease and ALS. As an example we criticize the emphasis that has been placed on correlating the presence of Lewy bodies with the diagnosis of Parkinson's disease. In essence, we submit that Parkinson's disease can exist without Lewy bodies, and Lewy bodies can exist without Parkinson's disease. Nevertheless, we consider that the newer techniques available to histology have led to an important concept that constitutes a shared feature for Alzheimer's disease. Parkinson's disease and ALS; they are all characterized by the deposition of cytoskeletal debris in tissue, so they may perhaps be collectively termed the “Cytoskeletal Disorders”.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 16 , Issue S4 , November 1989 , pp. 547 - 550
Copyright
Copyright © Canadian Neurological Sciences Federation 1989

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