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Regional Cerebral Glucose Metabolism in Turner Syndrome

Published online by Cambridge University Press:  18 September 2015

C. Clark ,
H. Klonoff  and
M. Hayden
C. Clark*
Affiliation:
Department of Psychiatry, University of British Columbia
H. Klonoff
Affiliation:
Department of Psychiatry, University of British Columbia
M. Hayden
Affiliation:
Department of Medical Genetics, University of British Columbia
*
Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, B.C., Canada V6T 2S1
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Abstract:

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Regional cerebral glucose metabolism was examined in females with Turner syndrome, a sex chromosome abnormality. Previous studies have found a visual/spatial cognitive anomaly in these women but, to date, no abnormalities in brain structure or function have been associated with the condition. In the present study, decreases in regional metabolism were found in the occipital and parietal cortex. The involvement of the occipital cortex, although consistent with the observed cognitive anomalies, has not been suggested previously as an area dysfunction. Because the occipital cortex is a primary sensory cortex, the reduction of glucose metabolism in the parietal cortex may reflect a lack of innervation from the occipital cortex. Besides insight into the functional specialization of the brain, these findings are also consistent with previous reports on animals regarding the effects of estrogen in brain maturation.

Résumé:

RÉSUMÉ:

Nous avons examiné le métabolisme cérébral régional du glucose chez des femmes porteuses du syndrome de Turner, une anomalie des chromosomes sexuels. Des études antérieures ont montré une anomalie cognitive visuo-spatiale chez ces femmes, mais à date, aucune anomalie dans la structure ou la fonction cérébrale n'a été associée à cette condition. Dans la présente étude, nous avons observé des diminutions du métabolisme régional dans le cortex occipital et pariétal. L'atteinte du cortex occipital, bien que compatible avec les anomalies cognitives observées, n'a pas été suggérée précédemment comme étant une dysfonction régionale. Parce que le cortex occipital est un cortex sensoriel primaire, la diminution du métabolisme du glucose dans le cortex pariétal peut refléter un manque d'innervation à partir du cortex occipital. En plus de fournir des indices sur la spécialisation fonctionnelle du cerveau, ces observations sont également compatibles avec des observations antérieures sur les animaux faisant état des effets des estrogènes dans la maturation du cerveau.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 17 , Issue 2 , May 1990 , pp. 140 - 144
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

References

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