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The Reactivity of Canine Cerebral Arteries to O2 and CO2 in Vitro

Published online by Cambridge University Press:  18 September 2015

P. Steinbok ,
M.J. Kendall ,
R.J. Clarke  and
S.J. Peerless
P. Steinbok*
Affiliation:
Division of Neurosurgery, Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada
M.J. Kendall
Affiliation:
Division of Neurosurgery, Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada
R.J. Clarke
Affiliation:
Division of Neurosurgery, Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada
S.J. Peerless
Affiliation:
Division of Neurosurgery, Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada
*
University of British Columbia, Department of Surgery, 700 West 10th Ave., Vancouver V5Z 1L5 Canada
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The responses of canine middle cerebral arteries to changes in pCO2 and pO2 were tested in vitro. It was found that there was no response to changes in pCO2 from 38.1 mm. Hg to 26.6 mm. Hg. but there was some constriction of the vessels with lowering of the pCO2 below 26.6 mm. Hg and there was minimal dilatation of the vessels when the pCO2 was increased from 38.1 nan. Hg to 87.2 mm. Hg. There was no reresponse to changes in pO2 from more than 500 mm. Hg to 59.6 mm. Hg, but when pO2 was lowered below 50 mm. Hg there was a sudden, massive constriction of the arteries tested. It is postulated that this constriction is due to build-up of a substance (substances) during a period of hypoxia (pO2 < 50 mm. Hg). The significance of the results obtained are discussed.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 3 , Issue 4 , November 1976 , pp. 255 - 262
Copyright
Copyright © Canadian Neurological Sciences Federation 1976

References

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