Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-24T03:31:57.686Z Has data issue: false hasContentIssue false

Pseudogout of the Transverse Atlantal Ligament: An Unusual Cause of Cervical Myelopathy

Published online by Cambridge University Press:  16 February 2016

Donald E.G. Griesdale Jr.
Affiliation:
Division of Neurosurgery, Combined Neurosurgical and Orthopedic Spine Program, Vancouver General Hospital, University of British Columbia, Vancouver BCCanada
Mike Boyd
Affiliation:
Division of Neurosurgery, Combined Neurosurgical and Orthopedic Spine Program, Vancouver General Hospital, University of British Columbia, Vancouver BCCanada
Ramesh L. Sahjpaul*
Affiliation:
Division of Neurosurgery, Combined Neurosurgical and Orthopedic Spine Program, Vancouver General Hospital, University of British Columbia, Vancouver BCCanada
*
3878 W 18th Ave, Vancouver BC V6S 1B5, Canada.
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Background:

Calcium pyrophosphate dihydrate deposition in the cervical spine is infrequently symptomatic. This is especially true at the craniocervical junction and upper cervical spine.

Case Report:

A 70-year-old previously healthy woman presented with a progressive cervical myelopathy of four months duration.

Results:

Examination revealed sensorimotor findings consistent with an upper cervical myelopathy. Radiological studies (plain radiographs, computed tomography, and magnetic resonance imaging) revealed C1-2 instability, and a well-defined extradural 3cm x 1cm retro-odontoid mass causing spinal cord compression. Transoral resection of the mass was performed followed by posterior C1-2 stabilization. Histological examination of the mass confirmed calcium pyrophosphate dihydrate deposition. Follow-up examination showed marked clinical and radiological improvement.

Conclusion:

Although uncommon, calcium pyrophosphate dihydrate deposition disease should be considered in the differential diagnosis of extradural mass lesions in the region of the odontoid.

Type
Case Report
Copyright
Copyright © The Canadian Journal of Neurological 2004

References

1.Zunkeler, B, Schelper, R, Menezes, AH. Periodontoid calcium pyrophosphate dihydrate deposition disease: “pseudogout” mass lesions of the craniocervical junction. J Neurosurg 1996;85:803809.CrossRefGoogle ScholarPubMed
2.Fye, KH, Weistein, PR, Donald, F. Compressive cervical myelopathy due to calcium pyrophosphate dihydrate deposition disease. Arch Intern Med 1999;159:189193.CrossRefGoogle ScholarPubMed
3.Ciricillo, SF, Weistein, PR. Foramen magnum syndrome from pseudogout of the atlanto-occipital ligament: case report. J Neurosurg 1989;71:141143.CrossRefGoogle ScholarPubMed
4.Ishida, T, Dorfmann, HD, Bullough, PG. Tophaceous pseudogout (tumoral calcium pyrophosphate dihydrate crystal deposition disease). Hum Pathol 1995;26:587593.CrossRefGoogle ScholarPubMed
5.Wells, CR, Morgello, S, Dicarlo, E. Cervical myelopathy due to calcium pyrophosphate dihydrate deposition disease. J Neurol Neurosurg Psychiatry 1991;54:658659.CrossRefGoogle ScholarPubMed
6.Assaker, R, Louis, E, Boutry, N, et al. Foramen magnum syndrome secondary to calcium pyrophosphate crystal deposition in the transverse ligament of the atlas. Spine 2001;26:13961400.CrossRefGoogle ScholarPubMed
7.Howell, DS. Diseases due to the deposition of calcium pyrophosphate and hydroxyapatite. In: Kelley, WN, Harris, ED, Ruddy, S, Sledge, CB, (Eds). Textbook of Rheumatology. Philadelphia, Pa: WB Saunders Co; 1981.Google Scholar
8.Markiewitz, A, Boumphrey, F, Bauer, T, et al. Calcium pyrophosphate dihydrate crystal deposition disease as a cause of lumbar canal stenosis. Spine 1996;21:506511.CrossRefGoogle ScholarPubMed
9.Takaaki, F, Nabeshima, Y, Shinji, Y, et al. Pseudogout attack of the lumbar facet joint: a case report. Spine 2002;27:396398.Google Scholar
10.Dirheimer, Y, Bensimon, C, Christmann, D, et al. Syndesmo-odontoid joint and calcium pyrophosphate dihydrate deposition disease (CPPD). Neuroradiology 1983;25:319321.CrossRefGoogle ScholarPubMed
11.Constantin, A, Marin, F, Fedele, M, et al. Calcification of the transverse ligament of the atlas in chondrocalcinosis: computed tomography study. Ann Rheum Dis 1996;55:137139.CrossRefGoogle ScholarPubMed
12.Muthukumar, N, Karuppaswamy, U. Tumoral calcium pyrophosphate dihydrate deposition disease of the ligamentum flavum. Neurosurgery 2003;53:103108.CrossRefGoogle ScholarPubMed