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Prevalence of Cognitive and Vestibular Impairment in Seniors Experiencing Falls

Published online by Cambridge University Press:  20 July 2020

Brenda Varriano
Affiliation:
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
Shaleen Sulway
Affiliation:
Hertz Multidisciplinary Neurotology Clinic, Toronto General Hospital, Toronto, ON, Canada
Curtis Wetmore
Affiliation:
Centre for Advanced Hearing and Balance Testing, Toronto General Hospital, Toronto, ON, Canada
Wanda Dillon
Affiliation:
Hertz Multidisciplinary Neurotology Clinic, Toronto General Hospital, Toronto, ON, Canada
Karen Misquitta
Affiliation:
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
Namita Multani
Affiliation:
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
Cassandra Anor
Affiliation:
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada
Maria Martinez
Affiliation:
Division of Neurology, Memory Clinic, Toronto Western Hospital, Toronto, ON, Canada
Elena Cacchione
Affiliation:
Division of Neurology, Memory Clinic, Toronto Western Hospital, Toronto, ON, Canada
John Rutka
Affiliation:
Hertz Multidisciplinary Neurotology Clinic, Toronto General Hospital, Toronto, ON, Canada Department of Otolaryngology-Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Maria Carmela Tartaglia*
Affiliation:
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada Division of Neurology, Memory Clinic, Toronto Western Hospital, Toronto, ON, Canada Division of Neurology, Krembil Neuroscience Centre, Toronto Western Hospital, Toronto, ON, Canada
*
Correspondence to: Carmela Tartaglia, MD, FRCPC, Associate Professor, University of Toronto, Toronto Western Hospital, 399 Bathurst St. WW5-449, Toronto, ONM5T 2S8, Canada. Email: [email protected]
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Abstract:

Background:

Falls are a growing concern in seniors (≥65 yrs). Cognitive impairment (CI) and vestibular impairment (VI) increase fall risk. The aim of this study is to assess the prevalence of CI and VI in seniors experiencing falls.

Methods:

Participants (≥65 yrs) with falls were recruited from Falls Prevention Programs (FPPs) and a Memory Clinic (MC). CI was assessed using the Montreal Cognitive Assessment at FPPs. VI was assessed at an MC and FFPs using the Head Impulse- (video + bedside), Headshake-, Dix-Hallpike test, and test of sensory interaction in balance. Questionnaires included Dizziness Handicap Inventory (DHI) and Activities-specific Balance Confidence Scale (ABC).

Results:

Of 41 participants (29 FPPs, 12 MC); mean age was 80.1 ± 7.1 years, and 58.5% were female. Overall, 82.9% had VI. At FPPs, 76.0% had CI, and 72.3% had CI + VI. Bilateral vestibular hypofunction (BVH) was more common than unilateral vestibular hypofunction (UVH) (70.6% vs. 29.4%); p = 0.016. Dizziness Handicap (DHI) was not different between those with a VI (23.5 ± 23.9) versus without VI [PVI + no impairment] (10.0 ± 15.4); p = 0.160. Balance confidence (ABC) was lowest in VI but not significantly different between those with a VI (63.4 ± 27.3) versus without VI [PVI + no impairment] (85.0 ± 16.5); p = 0.053.

Conclusions:

VI and CI are prevalent in seniors experiencing falls. For seniors with history of falls, both cognitive and vestibular functions should be considered in the assessment and subsequent treatment. Screening enables earlier detection, targeted interventions, and prevention, reducing the clinical and financial impact.

Résumé :

RÉSUMÉ :

Prévalence de déficit cognitif et de déficit vestibulaire chez des personnes âgées victimes de chutes.

Contexte :

Les chutes sont une préoccupation croissante chez les personnes âgées (≥ 65 ans). On sait aussi que les déficits cognitifs (DC) et les déficits vestibulaires (DV) peuvent en accroître le risque. Ainsi, le but de cette étude est d’évaluer la prévalence des DC et des DV chez des personnes âgées victimes de chutes.

Méthodes :

Âgés de 65 ans ou plus, nos participants avaient été victimes de chutes. Ils ont été recrutés dans le cadre d’un programme de prévention des chutes (PPC) et au sein d’une clinique de la mémoire (CM). Leurs DC ont été évalués au moyen de l’Évaluation cognitive de Montréal (MoCA) dans le cadre d’un PPC. Quant à leurs DV, ils ont été évalués dans une CM et dans le cadre d’un PPC à l’aide des tests suivants : test d’impulsion de la tête (head impulse) par vidéo et au chevet des patients ; manœuvre de secouage de la tête (headshake) ; test de Nylen-Bárány ; et test d’intégration sensorielle et d’équilibre (sensory interaction in balance). À noter que deux questionnaires ont également été utilisés : le Dizziness Handicap Inventory (DHI) et le Activities-specific Balance Confidence Scale (ABC).

Résultats :

Au total, 41 participants ont été recrutés, soit 29 dans le cadre d’un PPC et 12 autres au sein d’une CM. Leur âge moyen était 80,1 ± 7,1 ans ; 58,5 % d’entre eux étaient de sexe féminin. De façon générale, 82,9 % des participants étaient atteints de DV. Parmi ceux inclus dans un PPC, 76,0 % étaient atteints de DC tandis que 72,3 % étaient atteints à la fois de DC et de DV. Une hypo-fonction vestibulaire bilatérale s’est avérée plus courante qu’une hypo-fonction vestibulaires unilatérale (70,6 % contre 29,4 % ; p = 0,016). Les résultats au DHI ne se sont pas avérés différents entre ceux et celles atteints de DV (23,5 ± 23,9) et les autres qui n’en étaient pas atteints [PDV + aucune déficience] (10,0 ± 15,4 ; p = 0,160). Les résultats au ABC se sont par ailleurs révélés moins élevés chez les participants atteints de DV ; cela dit, la différence entre ces participants (63,4 ± 27,3) n’était en rien significative par rapport à ceux et celles n’étant pas atteints par un DV [PDV + aucune déficience] (85,0 ± 16,5 ; p = 0,053.

Conclusions :

Tant les DV que les DC sont donc répandus chez les personnes âgées victimes de chutes. Dans le cas de personnes âgées sans antécédents de chute, les fonctions cognitives et vestibulaires devraient être toutes deux analysées lors d’une évaluation et à l’occasion d’un traitement subséquent. Un tel dépistage permettrait ainsi une détection plus précoce, des interventions davantage ciblées et une meilleure prévention, ce qui en retour contribuerait à réduire l’impact clinique et financier.

Type
Original Article
Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press on behalf of The Canadian Journal of Neurological Sciences Inc.

Introduction

Falls are a growing concern in Canada and a leading cause of injury in seniors (≥65 yrs). Approximately 20–30% of senior’s experience ≥1 falls a year. Reference Stinchcombe, Kuran and Powell1 Current estimates place associated health care costs at $2 billion annually, and this number is expected to rise. Reference Stinchcombe, Kuran and Powell1

Fall risk factors appear to be multifactorial, suggesting a multifaceted approach is required. Reference Rubenstein2 Studies have shown a link between cognitive status and increased number of falls in the elderly Reference Harlein, Dassen, Halfens and Heinze3 with cognitive impairment (CI) correlating with a 2–3-fold increased risk of falling. Reference Harlein, Dassen, Halfens and Heinze3 In one study, a falls prevention program (FPP) reduced falls in those with higher cognitive functioning but not in those with more impaired cognition, suggesting that some strategies may not be effective in those with cognitive impairment. Reference Jensen, Nyberg, Gustafson and Lundin-Olsson4 Other studies suggest that multimodal exercise programs may be useful for improving balance and gait in those with cognitive impairment; however, the optimal program has not been established and warrants further research. Reference Cadore, Rodriguez-Manas, Sinclair and Izquierdo5 Finally, it has been suggested that cognitive and vestibular impairment (VI) can increase in parallel. Reference Bigelow, Semenov and Trevino6 In one study, VI was prevalent in patients with either a diagnosis of mild cognitive impairment (MCI) or Alzheimer’s Disease (AD), Reference Harun, Oh, Bigelow, Studenski and Agrawal7 and another study reported higher prevalence of VI in elderly AD patients compared to non-AD patients and young adults. Reference Nakamagoe, Fujimiya and Koganezawa8

Often clinically overlooked as a risk factor for falls is the vestibular system, which is responsible for balance and awareness of body positioning in space. A study reported that one in five of elderly persons experience issues with dizziness and balance annually, symptoms common with vestibular impairment. Reference Lin and Bhattacharyya9 It is known that seniors can have age-related changes in the vestibular system that can lead to symptoms, such as dizziness and balance issues. Reference Agrawal, Carey, Della Santina, Schubert and Minor10 A cross-sectional survey in the US, that tested vestibular functioning, had previously shown that 35.4% of US adults aged 40 and older had a vestibular impairment, and that this number rose to 85% in those aged 80 and older. Reference Agrawal, Carey, Della Santina, Schubert and Minor10 Moreover, VI correlated with a 12-fold increased risk of falling in those that were defined as being clinically symptomatic (i.e. experienced dizziness). Reference Agrawal, Carey, Della Santina, Schubert and Minor10 These numbers suggest a high prevalence of vestibular issues; however, one limitation with the data from the National Health and Nutrition Examination Survey study was that VI was diagnosed solely using the modified clinical test of sensory interaction in balance (mCTSIB), which may have caused an overestimation of those diagnosed with a vestibular impairment. Reference Agrawal, Carey, Della Santina, Schubert and Minor10 A case-controlled study revealed that among seniors experiencing multiple falls, approximately 80% had a VI, while only 18.5% age-matched controls without falls had a vestibular deficit. Reference Liston, Bamiou and Martin11 As per this study, vestibular functioning was assessed by caloric, electronystagmography (ENG), and Dix-Hallpike test.

Rehabilitation programs are available to reduce symptoms of VI; however, there is little research investigating the prevalence of VI in seniors with CI and experiencing falls. Since CI is common in seniors experiencing falls and there is a research gap about the prevalence of combined cognitive and vestibular impairment, this study investigated the prevalence of VI in participants attending a Memory Clinic (MC) and the prevalence of both cognitive and VI in participants attending a Falls Prevention Program (FPP).

Methods

Full approval was obtained from the University Health Network (UHN) Research Ethics Board (REB) for this study [ID: 17-5055.0]. Written consent was obtained from all subjects, as outlined by the UHN research protocol. All patients were able to consent for themselves.

Participants

Participants were recruited from two community FPPs and an outpatient MC from September 2017 to March 2018. Participants were admitted to the falls prevention program if they or a health care provider had reported a fall in the past year. Participants at FPP were approached by FPP personnel and if they were both interested and meeting study inclusion criteria, they were referred to the study team. Research personnel confirmed inclusion/exclusion criteria. The research personnel did not have information on the total number of participants approached by the FPP personnel. MC subjects were selected from a chart review if they had fallen in the past year, which was indicated in their charts and confirmed when receiving consent.

Inclusion criteria from the FPPs: (1) 65 years or older, (2) English speaking, (3) capable of providing consent, and (4) have fallen in the past year. Participants were excluded if they reported: (1) neurological disease, (2) acute ear infection, (3) severe neck arthritis, or (4) any other illness, which may have prevented participation in the study.

Inclusion criteria from the MC were the same as FPP with the addition of a diagnosis of MCI or early dementia (early AD, Vascular Cognitive Impairment, or Mixed Dementia due to AD and Vascular Cognitive Impairment) as determined by the Montreal Cognitive Assessment (MoCA) score >15 and <26, biomarkers, CSF, and imaging, where appropriate and as outlined in diagnostic criteria. Reference Petersen, Lopez and Armstrong12Reference McKhann, Knopman and Chertkow16 These specific diagnoses were made by an MC neurologist, using AD biomarkers and/or imaging, and were recorded in the patient charts. Patients were excluded if they had any of the following comorbidities recorded in their chart: (1) additional neurological disease, (2) psychiatric disorder, (3) acute ear infection, (4) severe neck arthritis, or (5) alternative etiology of dementia (i.e. Huntington’s Disease, Lewy Body Dementia, etc.).

Data on proprioception and the use of benzodiazepines, hypnotics, and anticholinergic medications were only available for MC patients. These data were collected from their medical charts.

Outcomes – Vestibular Impairment

VI was assessed in seniors experiencing falls from both sites (FPP and MC). The following assessments were used to diagnose vestibular impairment: (1) Dix-Hallpike test, Reference Dix and Hallpike17 (2) video- and bedside-head impulse test (vHIT and bHIT, respectively), Reference MacDougall, Weber, McGarvie, Halmagyi and Curthoys18 (3) the Headshake Test, Reference Hain, Fetter and Zee19 and (4) modified clinical test of sensory interaction in balance (mCTSIB). Reference Cohen, Blatchly and Gombash20 All bedside vestibular tests were performed and interpreted by a vestibular physiotherapist. The vestibular audiologist performed the vHIT test and interpreted the results. Both clinicians were blinded to one another’s results. VI was diagnosed if the participant had abnormalities on the Dix-Hallpike, vHIT, bHIT, or Headshake test. Possible vestibular impairment (PVI) was diagnosed if a participant failed the mCTSIB alone. Reference Cohen, Blatchly and Gombash20 VOR loss on either side alone was diagnosed as unilateral vestibular hypofunction (UVH), and loss on both sides was diagnosed as bilateral vestibular hypofunction (BVH). Both the vHIT and bHIT were used, as the researchers were interested in assessing the feasibility and usefulness of the bHIT as a future screening tool for vestibular impairments in FPPs. At present, no vestibular testing is included in the initial assessments at FPPs.

vHIT was performed using ICS impulse Video Goggles [GN Otometrics, Taastrup, Denmark] with a camera speed of 250 frames/s and followed the standard procedure described by McGarvie et al., 2015. Reference McGarvie, MacDougall, Halmagyi, Burgess, Weber and Curthoys21 Participants were instructed to sit at eye level to a small target that was 1 meter in front of them. Participants were instructed to remove their corrective lenses if needed, and a foam insert was used to minimize slippage of goggles. Reference McGarvie, MacDougall, Halmagyi, Burgess, Weber and Curthoys21 Eye positioning calibration was carried out for all patients by getting the patient to fixate on laser targets on the wall. Neck range of motion was verified prior to testing, and range of motion was modified if any neck stiffness was reported. The audiologist performed a series of head impulses at varying velocities in the horizontal plane only [>120 deg/s up and 300 deg/s]. Reference McGarvie, MacDougall, Halmagyi, Burgess, Weber and Curthoys21 These movements were in random order and direction. Participants were instructed to focus on the target, as their head position was altered from neutral to 20° left or right. The computer software measured head velocity as compared to eye velocity in the opposite direction in order to assess the VOR. Average vHIT gain was calculated with GN Otometrics software as outlined by McGarvie et al. (2015), and any corrective saccades made during the head impulse were recorded. Reference McGarvie, MacDougall, Halmagyi, Burgess, Weber and Curthoys21 Each head impulse was then interpreted by the vestibular audiologist to ensure that an acceptable impulse was received. A positive vHIT was defined as (1) gain of 0.8 or lower in the horizontal plane with corrective saccades or (2) an observable overt/covert saccade that measured 50% or greater than that of the head velocity. Reference Moon, Chang and Kim22

For the bHIT, patients were seated at the eye level of the vestibular PT and asked to focus on a distant target that was 6 feet away. Reference Crane and Demer23 The patients’ head was rotated 20° to the left or right direction, and a rapid thrust was applied bringing the head back to midline. An abnormal test was the presence of an overt saccade (OS). Despite the poor psychometrics of the bHIT, both the vHIT and bHIT were used to see if clinically, the bHIT could be an option in falls prevention program screenings. The bHIT would be a useful first step in flagging patients for further clinical assessments, as the vHIT is costly, laborious, and not feasible as a screening tool.

The Headshake test was utilized to test for vestibular asymmetry, suggesting a UVH. For the Headshake test, the patient began in an upright seated position, wearing infrared goggles. Reference Hain, Fetter and Zee19 The patient’s head was fixated 30° downward and oscillated horizontally for 30 s at a speed of 2 Hz. Eyes were then monitored for the presence of nystagmus, with elicitation of three or greater beats, indicating vestibular asymmetry. Reference Hain, Fetter and Zee19

For the mCTSIB, a pre-calibrated Nintendo Wii™ Balance board containing four transducers was used for the detection of force distribution and the resultant movements in the center of pressure (COP). It communicated the pressure changes to a laptop via Bluetooth for the collection of the COP data. Data obtained included total time standing, path distance travelled (path length), and root mean squares (RMS) [anterior–posterior and resultant directions]. Reference Goble, Cone and Fling24 The “Balance Workshop” Software was used to capture the data. Reference Cohen, Blatchly and Gombash20,Reference Hughes, Pothier, Ranalli and Rutka25,Reference Hubbard, Pothier and Hughes26 A fall prior to 30 s in condition 4 (on foam [AIREX® Balance Pad] with eyes closed) was considered a positive test for possible vestibular impairment, since balance in condition 4 is more reliant on the vestibular system.

Outcomes – Cognitive Impairment

The potential of having a CI was assessed in seniors experiencing falls in an FPP and estimated by performance on the MoCA. The MoCA (Version 7.1) was used to assess cognition and administered by a trained vestibular nurse and a graduate student. A score of 16–25 was categorized as a low MoCA score, while a score lower than 16 was categorized as very low MoCA score. Although no imaging or diagnostic markers were used at FPPs, these scores would typically be seen in those with MCI or dementia, respectively. Reference Ciesielska, Sokolowski, Mazur, Podhorecka, Polak-Szabela and Kedziora-Kornatowska27,Reference Nasreddine, Phillips and Bedirian28 However, due to the absence of additional testing, patients were categorized by performance on MOCA and not given a diagnosis.

Outcomes – Dizziness and Balance Questionnaires

Subjective questionnaires included the Dizziness Handicap Inventory (DHI) Reference Jacobson and Newman29 to quantify self-perceived handicap due to symptoms of dizziness and the Activities-specific Balance Confidence Scale (ABC) Reference Powell and Myers30 to evaluate a patient’s confidence to maintain balance while performing various activities. Reference Jacobson and Newman29 For the DHI, the higher the score out of 100, the greater the patient’s perceived handicap due to dizziness. Scores lower than 67% on the ABC are associated with an increased risk of falling. Reference Lajoie and Gallagher31

Statistics

Descriptive statistics were described using proportions and frequencies. Mean and standard deviations were used to describe continuous variables. Statistical analysis regarding the prevalence of VI included both MC patients and patients from FPPs. Statistical analysis regarding the prevalence of CI included only participants from FPPs. The chi-square test was used to test for differences in the proportion of males versus females in our sample of VI and to assess for differences in the proportion of those diagnosed with BVH versus UVH. Student’s t-tests were used to determine differences in mean scores of the DHI and ABC between those with VI or no VI (NVI + PVI). A p-value of <0.05 was considered statistically significant. All statistics were performed using SPSS Software Version 25 [IBM™].

Results

Demographics and Vestibular Impairment

Of the 41 participants who were assessed, 29 (70.7%) participants were from FPPs, and 12 (29.3%) participants were from an MC. The overall mean age was 80.1 ± 7.1 years (81.2 ± 7.1 years in FPP vs. 77.3 ± 6.7 years in MC). Data from our MC patients only revealed 3/12 (25%) had a proprioceptive deficit, and only 3/12 (25%) were on an anticholinergic medication at the time of the study. None of the MC patients were on benzodiazepines or hypnotics. Of our total patient population, 58.5% of all participants were female (69% of participants were female at FPPs vs. 33.3% of participants were female at MC). Overall, 34/41 (82.9%) of those screened had VI, 3/41 (7.3%) had PVI due to failure of condition 4 on the mCTSIB alone, and 4/41 (9.8%) had NVI; see Table 1. Mean age of those with VI was 81.0 ± 7.2 years, and mean age of those with NVI was 74.3 ± 4.5 years. VI was significantly more common in females 23/34 (67.6%) than in males 11/34 (32.4%); p = 0.040. Of those with a VI, BVH (70.6%) was significantly more common than UVH (29.4%); p = 0.016. Of those with VI, average gain on the vHIT was 0.89 ± 0.18 on the left-hand side and 0.96 ± 0.16 on the right-hand side, respectively. All gain values are shown in Table 1. Overt and covert saccades are shown in Figure 1 and Supplementary Figures 14, respectively. MC recruitment is shown in Supplementary Figure 5.

Table 1: Prevalence of VI in falls prevention programs and an MC (N = 41)

ABC – activities specific balance confidence scale, BVH – Bilateral vestibular hypofunction, DHI – Dizziness Handicap Inventory, VI – Definite Vestibular Impairment, NVI – No vestibular impairment, PVI – Possible Vestibular Impairment, UVH – Unilateral Vestibular Hypofunction.

* Prevalence of UVH and BVH is within the VI group.

Figure 1: Presence of OS and CS in those with a VI and an abnormal Video Head Impulse Test (N = 27).

VI was diagnosed based on an abnormal vestibular assessment (Table 2). Some patients declined to complete some parts of the assessment, due to discomfort or physical constraints; i.e. high reliance on a walker to stand. Of these 34 patients with VI, 32/34 (94.1%) participants completed the vHIT, and 27/32 (84.3%) had abnormal results; 33/34 (97.1%) participants completed the bHIT, and 31/33 (93.9%) had abnormal results; 34 (100%) were assessed with the Dix-Hallpike test, and 2/34 (5.9%) were diagnosed with BPPV; 33/34 (94.1%) completed the Headshake test, and 8/33 (24.2%) had nystagmus post headshake. There was discordance between bHIT and vHIT for 4/32 participants that had completed both the bHIT and vHIT. The discordance was attributed to poor fit of the vHIT goggles, resulting in the audiologist to feel that the results were indeterminant. Therefore, in these cases, if corrective saccades were seen by the clinician doing the vHIT, the patient was categorized as positive for vestibular impairment.

Table 2: Abnormal tests of vestibular functioning in those with VI (N = 34)

BPPV – Benign paroxysmal positional vertigo, VOR – Vestibulo-ocular reflex.

** Prevalence is based on the proportion of participants completing the tests.

Overall, 39/41 patients completed the mCTSIB; 22/39 (62.9%) of those patients failed condition 4 (foam, eyes closed), and 3/22 (13.6%) failed only condition 4 of the mCTSIB, with no other abnormalities on any other test, so were considered to have PVI. All values for path length, RMS, and time standing are included in Table 3.

Table 3: Modified Clinical Test of Sensory Interaction on Balance (mCTSIB) scores for those with and without a VI (N = 39)*

VI – Vestibular Impairment, NVI – No Vestibular Impairment, PVI – Possible Vestibular Impairment.

* Two participants with VI were unable to complete the mCTSIB.

Cognitive Impairment

Of 29 participants assessed at FPPs, 25 participants completed an MoCA (see Table 4). Four participants were unable to complete the MoCA because of previously diagnosed CI and an inability to understand the MoCA instructions. Overall, 19/25 (76.0%) of participants scored low or very low on the MoCA (Table 4). Of those with poor MoCA scores, 13/25 (52.0%) had MoCA between 16 and 25 (low score), and 6/25 (24.0%) had a score between 0 and 15 (very low score). Of the 22 who completed an MoCA, 16/22 (72.3%) had both a low/very low score and VI.

Table 4: MoCA performance in seniors experiencing falls at FPPs (N = 25)* to assess cognitive functioning

* Only 25 participants had completed an MoCA.

Questionnaires

Those with VI had lower mean scores on the ABC, compared to those with PVI or NVI (Table 1). There was a trend for lower confidence scores and suggestion of falls risk on the ABC in those with a VI versus those without VI (PVI + NVI), 63.4 ± 27.3 versus 85.0 ± 16.5; p = 0.053, respectively. Most participants [25/41 (60.1%)] had an ABC score greater than 67%, which is above the cutoff for falls risk. Of the 16 with a low confidence score on the ABC (score <67%), 15/16 (93.8%) also had a VI.

Higher mean scores on the DHI suggesting more dizziness handicap were more common in those with VI compared to PVI or NVI (Table 1). However, there was no significant difference in dizziness score between these groups: 23.5 ± 23.9 and 10.0 ± 15.4, respectively; p = 0.160.

Discussion

The study results demonstrate that both VI and CI are common in seniors experiencing falls. The high proportion of VI in our study builds on previous findings, suggesting that there is a higher prevalence of vestibular impairments in older adults experiencing falls compared to age-matched non-fallers. Reference Liston, Bamiou and Martin11 In addition, other studies have suggested that there is an increased risk of experiencing a fall in seniors with cognitive impairment. Reference Delbaere, Kochan and Close32,Reference Liu-Ambrose, Ashe, Graf, Beattie and Khan33 However, our study adds to these findings, suggesting that CI may be more common in seniors experiencing falls with VI. Herdman et al. Reference Herdman, Blatt, Schubert and Tusa34 have also suggested that falls are more prevalent in people with VI compared to no VI, in addition to those with BVH compared to UVH.

The vestibular system plays a role in cognition, and this includes perception of self-motion, body awareness, and spatial navigation, spatial learning, and spatial memory. Reference Hitier, Besnard and Smith35 Therefore, it is possible that those with a VI may also have a CI, adding another issue to overcome when designing falls prevention programs. Previous studies have reported associations between VI and impaired visuospatial functioning in those without a formal diagnosis of CI, Reference Bigelow, Semenov and Trevino6 and in those with either a diagnosis of MCI or AD versus those that are cognitively healthy. Reference Harun, Oh, Bigelow, Studenski and Agrawal7 In addition, those with MCI or AD have a threefold increased risk of having a VI compared to those without CI. Reference Harun, Oh, Bigelow, Studenski and Agrawal7 Nakamagoe et al. Reference Nakamagoe, Fujimiya and Koganezawa8 compared the presence of VI in elderly AD patients versus non-AD patients and young adults and found that there was a significant impairment in balance in 75% of patients with AD (as determined by a stepping test), compared to 25% in non-AD older adults and 0% in younger adults. In addition, VI (as defined by absent/reduced amplitude of eye movement during the caloric test) was more common in older patients with AD, compared to older patients without AD and younger patients. Reference Nakamagoe, Fujimiya and Koganezawa8 This suggests that both vestibular and cognitive impairment commonly present together and should be considered when designing falls prevention programs.

Both vestibular and cognitive function can be relatively easily screened using validated bedside tests and subjective questionnaires. However, it has been difficult to determine when to screen for vestibular impairment, since not all patients will present with dizziness. Reference Agrawal, Carey, Della Santina, Schubert and Minor10 This study sought to assess subjective measures of a participant’s perceived dizziness; however, despite the high prevalence of VI, the overall DHI scores among all participants were quite low. It is possible that CI may be limiting their ability to complete the questionnaire or recall symptoms. More research is required to assess the validity of the DHI in those with cognitive impairment. Overall participants with VI reported lower balance confidence with activities of daily living (63%). In analyzing the data, there was a trend suggesting higher dizziness handicap and poorer balance confidence in the VI group compared to those with NVI, although the results did not reach statistical significance, likely due to low sample size in the NVI group.

The FPPs known to the authors do not screen for vestibular and/or cognitive impairments, which likely provides a gap in understanding the potential factors impacting a patient’s success or failure in the FPP. Also, the current treatment programs in FPPs do not incorporate any vestibular therapy exercise programs, programs that have been demonstrated to be very effective in certain populations, and might be a potential solution for those with both a cognitive and vestibular impairment. Reference Hillier and McDonnell36

Poor performance on the MoCA was common in those attending an FPP. Overall, 72.3% of those with VI and 100% of those with PVI or no VI performed poorly on the MoCA. Given that education is an essential part of FPP, it is crucial that patients’ cognitive function be assessed so as to tailor the FPP for all patients attending.

MCs have an obvious function mitigating and accommodating the impact of CI. Given this study, and other published evidence, Reference Popp, Wulff, Finke, Rühl, Brandt and Dieterich37 that suggest a strong relationship between CI and VI, there could be a role to refer for vestibular assessments and treatments or provide integrated programs. Research suggests that balance training can have a positive effect on memory and spatial cognition; Reference Rogge, Röder and Zech38 therefore, the collaboration between community falls prevention programs and MCs can improve patient outcomes through referral and design of targeted programs.

The study has some limitations, the most notable being our small sample size, and lack of a control group consisting of seniors with no history of falls. Without a control group, we cannot ascertain if falls are due to vestibular or cognitive impairment, or if both impairments are common in the aging population overall with or without experiencing falls. However, our study does highlight the need to further investigate risk factors in falls. Although our study recruited from both an MC and an FPP, neither can ensure generalizability to the general population. Due to the high prevalence of VI, we could not compare questionnaire results with those having PVI or NVI. Another notable limitation was our limited usage of vestibular function tests to quantify the extent of the vestibular loss; we did not use the caloric test to assess the full spectrum of vestibular function, but we were able to look at the high-velocity range of the VOR with the vHIT. We did have unexpected findings with the HIT. There were a higher number of participants with an abnormal bHIT versus the vHIT. The bHIT has moderate sensitivity for detecting VOR deficits even by experienced clinicians [sensitivity = 66.3–86.84%]. Aside from some indeterminate results with the vHIT due to goggle slippage, the other cause of the discordance between the bHIT and vHIT was likely the cutoff value of 0.80 or less required for an abnormal vHIT. Gain values are often inaccurate in detecting a VI, because they are always averages of all the head impulses [high and low velocity]. Reference Blödow, Pannasch and Walther39,Reference Janky, Patterson and Shepard40 If an abnormal gain was present at a high velocity, but not at a low velocity; then, the average gain may fall within the normal limits. Some participants did, in fact, have abnormal gains at higher head velocities, but the overall gain values were within normal ranges due to the average gain calculation. Another contributor to the discordance was that the audiologist only considered covert or overt saccades in the tracing as abnormal if they were more than 50% of the velocity of the head impulse, whereas all saccades regardless of magnitude were considered abnormal for the bHIT. Although the bHIT has moderate sensitivity for detecting VOR deficits, it is a good test for identifying most normal cases and has been regarded as a clinically useful test and the only bedside test for the examination of high-frequency VOR. Reference Yip, Glaser, Frenzel, Bayer and Strupp41 Overall, we believe that the bHIT is a useful tool for clinical assessment of patients at risk of falls and should be incorporated into screening assessments as this is an easy, inexpensive test that can detect covert saccades (CS) seen in vestibular impairment, as long as the person who administers the test is properly trained. Furthermore, we did not assess other covariates of interest, which are known to impact risk of falls, such as medication use, proprioceptive deficits, musculoskeletal issues, or hearing-aid use. Given that a small portion of our MC patients had a proprioceptive deficit, we hope to incorporate this assessment into future studies on falls in patients with cognitive impairment.

These limitations do not reduce the significance of our study, which highlights a concern that should be further explored in other sites and in larger populations. Given the consequences of falls for the patient and health care system, all risk factors and solutions must be explored. Given that vestibular and cognitive impairment is common in older adults enrolled in falls prevention programs, novel assessments are warranted to assess fall risk. Dual-task gait function has been used to assess for gait disruptions in individuals with CI so may be a useful tool for participants in falls prevention programs. Moreover, vestibular deficits are amenable to therapy, and targeting the vestibular system may be an approach to reducing the risk of falls in seniors. Reference Hillier and McDonnell36 Additionally, future studies should address all factors contributing to risk of falls, given the interplay among the vestibular system, higher cognitive centers, and proprioception.

In conclusion, a comprehensive evaluation of seniors with a history of falls, or at risk of falls, should include both cognitive and vestibular assessments. Effective screening would enable earlier detection, targeted interventions, and prevent falls, which could reduce the clinical and financial impact on both the patient and the health care system.

ACKNOWLEDGEMENTS

We would like to thank all patients and caregivers who participated in this study. We thank our colleagues from the Toronto General ENT clinic. We thank Dr. Naglie and Dr. Mansfield, who provided insight and expertise that greatly assisted the research.

Conflict of Interest

The authors report no conflict of interest.

STATEMENT OF AUTHORSHIP

BV is responsible for study design, recruitment, data analysis, and authorship of the manuscript. SS, CW, and WD were responsible for performing tests of vestibular functioning, questionnaires, and editing of the manuscript. CA, NM, and KM assisted with questionnaires. EC and MM assisted with recruitment. JR provided access to vestibular testing equipment and guidance. MCT is the primary investigator.

Supplementary material

To view supplementary material for this article, please visit https://doi.org/10.1017/cjn.2020.154.

References

Stinchcombe, A, Kuran, N, Powell, S. Report summary. Seniors’ falls in Canada: second report: key highlights. Chron Dis Inj Can. 2014;34(2–3):171–4.CrossRefGoogle ScholarPubMed
Rubenstein, LZ. Falls in older people: epidemiology, risk factors and strategies for prevention. Age Ageing. 2006;35(Suppl_2):ii3741.CrossRefGoogle ScholarPubMed
Harlein, J, Dassen, T, Halfens, RJ, Heinze, C. Fall risk factors in older people with dementia or cognitive impairment: a systematic review. J Adv Nurs. 2009;65(5):922–33.CrossRefGoogle ScholarPubMed
Jensen, J, Nyberg, L, Gustafson, Y, Lundin-Olsson, L. Fall and injury prevention in residential care—effects in residents with higher and lower levels of cognition. J Am Geriatr Soc. 2003;51(5):627–35.CrossRefGoogle ScholarPubMed
Cadore, EL, Rodriguez-Manas, L, Sinclair, A, Izquierdo, M. Effects of different exercise interventions on risk of falls, gait ability, and balance in physically frail older adults: a systematic review. Rejuv Res. 2013;16(2):105–14.CrossRefGoogle ScholarPubMed
Bigelow, RT, Semenov, YR, Trevino, C, et al. Association between visuospatial ability and vestibular function in the Baltimore Longitudinal Study of Aging. J Am Geriatr Soc. 2015;63(9):1837-44.CrossRefGoogle ScholarPubMed
Harun, A, Oh, ES, Bigelow, RT, Studenski, S, Agrawal, Y. Vestibular impairment in dementia. Otol Neurotol. 2016;37(8):1137.CrossRefGoogle ScholarPubMed
Nakamagoe, K, Fujimiya, S, Koganezawa, T, et al. Vestibular function impairment in Alzheimer’s disease. J Alzheimer’s Dis. 2015;47(1):185–96.CrossRefGoogle ScholarPubMed
Lin, HW, Bhattacharyya, N. Balance disorders in the elderly: epidemiology and functional impact. Laryngoscope. 2012;122(8):1858–61.CrossRefGoogle ScholarPubMed
Agrawal, Y, Carey, JP, Della Santina, CC, Schubert, MC, Minor, LB. Disorders of balance and vestibular function in US adults: data from the National Health and Nutrition Examination Survey, 2001-2004. Arch Intern Med. 2009;169(10):938-44.CrossRefGoogle ScholarPubMed
Liston, MB, Bamiou, DE, Martin, F, et al. Peripheral vestibular dysfunction is prevalent in older adults experiencing multiple non-syncopal falls versus age-matched non-fallers: a pilot study. Age Ageing. 2014;43(1):3843.CrossRefGoogle ScholarPubMed
Petersen, RC, Lopez, O, Armstrong, MJ, et al. Practice guideline update summary: mild cognitive impairment: report of the guideline development, dissemination, and implementation subcommittee of the American Academy of Neurology. Neurology. 2018;90(3):126–35.CrossRefGoogle ScholarPubMed
Petersen, RC, Stevens, JC, Ganguli, M, Tangalos, EG, Cummings, J, DeKosky, S. Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review) report of the quality standards subcommittee of the American Academy of Neurology. Neurology. 2001;56(9):1133-42.CrossRefGoogle ScholarPubMed
Gorelick, PB, Scuteri, A, Black, SE, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42(9):2672–713.CrossRefGoogle ScholarPubMed
Rockwood, K, Macknight, C, Wentzel, C, et al. The diagnosis of “mixed” dementia in the Consortium for the Investigation of Vascular Impairment of Cognition (CIVIC). Ann NY Acad Sci. 2000;903(1):522–8.CrossRefGoogle Scholar
McKhann, GM, Knopman, DS, Chertkow, H, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):263–9.CrossRefGoogle Scholar
Dix, MR, Hallpike, CS. The pathology, symptomatology and diagnosis of certain common disorders of the vestibular system. Ann Otol Rhinol Laryngol. 1952;61(4):9871016.CrossRefGoogle ScholarPubMed
MacDougall, HG, Weber, KP, McGarvie, LA, Halmagyi, GM, Curthoys, IS. The video head impulse test: diagnostic accuracy in peripheral vestibulopathy. Neurology. 2009;73(14):1134–41.CrossRefGoogle ScholarPubMed
Hain, TC, Fetter, M, Zee, DS. Head-shaking nystagmus in patients with unilateral peripheral vestibular lesions. Am J Otolaryngol. 1987;8(1):3647.CrossRefGoogle ScholarPubMed
Cohen, H, Blatchly, CA, Gombash, LL. A study of the clinical test of sensory interaction and balance. Phys Ther. 1993;73(6):346–51; discussion 51–4.CrossRefGoogle ScholarPubMed
McGarvie, LA, MacDougall, HG, Halmagyi, GM, Burgess, AM, Weber, KP, Curthoys, IS. The video head impulse test (vHIT) of semicircular canal function–age-dependent normative values of VOR gain in healthy subjects. Front Neurol. 2015;6:154.CrossRefGoogle ScholarPubMed
Moon, M, Chang, SO, Kim, MB. Diverse clinical and laboratory manifestations of bilateral vestibulopathy. Laryngoscope. 2017;127(1):E42-9.CrossRefGoogle ScholarPubMed
Crane, BT, Demer, JL. Human gaze stabilization during natural activities: translation, rotation, magnification, and target distance effects. J Neurophysiol. 1997;78(4):2129–44.CrossRefGoogle ScholarPubMed
Goble, DJ, Cone, BL, Fling, BW. Using the Wii Fit as a tool for balance assessment and neurorehabilitation: the first half decade of “Wii-search”. J Neuroeng Rehabil. 2014;11(1):12.CrossRefGoogle ScholarPubMed
Hughes, CO, Pothier, DD, Ranalli, P, Rutka, JA. Balance workshop: synchronized head and force plate measurements. The potential for diagnostic yields. Int J Surg. 2014;12:S43.CrossRefGoogle Scholar
Hubbard, B, Pothier, D, Hughes, C, et al. A portable, low-cost system for posturography: a platform for longitudinal balance telemetry. J Otolaryngol Head Neck Surg. 2012;41(1):S31.Google ScholarPubMed
Ciesielska, N, Sokolowski, R, Mazur, E, Podhorecka, M, Polak-Szabela, A, Kedziora-Kornatowska, K. Is the Montreal Cognitive Assessment (MoCA) test better suited than the Mini-Mental State Examination (MMSE) in mild cognitive impairment (MCI) detection among people aged over 60? Meta-analysis. Psychiatr Pol. 2016;50(5):1039–52.CrossRefGoogle Scholar
Nasreddine, ZS, Phillips, NA, Bedirian, V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695-9.CrossRefGoogle ScholarPubMed
Jacobson, GP, Newman, CW. The development of the Dizziness Handicap Inventory. Arch Otolaryngol Head Neck Surg. 1990;116(4):424–7.CrossRefGoogle ScholarPubMed
Powell, LE, Myers, AM. The Activities-specific Balance Confidence (ABC) Scale. J Gerontol A Biol Sci Med Sci. 1995;50a(1):M28–34.CrossRefGoogle ScholarPubMed
Lajoie, Y, Gallagher, S. Predicting falls within the elderly community: comparison of postural sway, reaction time, the Berg balance scale and the Activities-specific Balance Confidence (ABC) scale for comparing fallers and non-fallers. Arch Gerontol Geriatr. 2004;38(1):1126.CrossRefGoogle ScholarPubMed
Delbaere, K, Kochan, NA, Close, JC, et al. Mild cognitive impairment as a predictor of falls in community-dwelling older people. Am J Geriatr Psychiatr. 2012;20(10):845–53.CrossRefGoogle ScholarPubMed
Liu-Ambrose, TY, Ashe, MC, Graf, P, Beattie, BL, Khan, KM. Increased risk of falling in older community-dwelling women with mild cognitive impairment. Phys Ther. 2008;88(12):1482-91.CrossRefGoogle ScholarPubMed
Herdman, SJ, Blatt, P, Schubert, MC, Tusa, RJ. Falls in patients with vestibular deficits. Otol Neurotol. 2000;21(6):847–51.Google ScholarPubMed
Hitier, M, Besnard, S, Smith, PF. Vestibular pathways involved in cognition. Front Integr Neurosci. 2014;8:59.CrossRefGoogle ScholarPubMed
Hillier, S, McDonnell, M. Is vestibular rehabilitation effective in improving dizziness and function after unilateral peripheral vestibular hypofunction? An abridged version of a Cochrane review. Eur J Phys Rehabil Med. 2016;52(4):541–56.Google ScholarPubMed
Popp, P, Wulff, M, Finke, K, Rühl, M, Brandt, T, Dieterich, M. Cognitive deficits in patients with a chronic vestibular failure. J Neurol. 2017;264(3):554–63.CrossRefGoogle ScholarPubMed
Rogge, A-K, Röder, B, Zech, A, et al. Balance training improves memory and spatial cognition in healthy adults. Sci Rep. 2017;7(1):5661.CrossRefGoogle ScholarPubMed
Blödow, A, Pannasch, S, Walther, LE. Detection of isolated covert saccades with the video head impulse test in peripheral vestibular disorders. Auris Nasus Larynx. 2013;40(4):348–51.CrossRefGoogle ScholarPubMed
Janky, KL, Patterson, J, Shepard, N, et al. Video head impulse test (vHIT): the role of corrective saccades in identifying patients with vestibular loss. Otol Neurotol. 2018;39(4):467–73.CrossRefGoogle ScholarPubMed
Yip, CW, Glaser, M, Frenzel, C, Bayer, O, Strupp, M. Comparison of the bedside head-impulse test with the video head-impulse test in a clinical practice setting: a prospective study of 500 outpatients. Front Neurol. 2016;7:58.CrossRefGoogle Scholar
Figure 0

Table 1: Prevalence of VI in falls prevention programs and an MC (N = 41)

Figure 1

Figure 1: Presence of OS and CS in those with a VI and an abnormal Video Head Impulse Test (N = 27).

Figure 2

Table 2: Abnormal tests of vestibular functioning in those with VI (N = 34)

Figure 3

Table 3: Modified Clinical Test of Sensory Interaction on Balance (mCTSIB) scores for those with and without a VI (N = 39)*

Figure 4

Table 4: MoCA performance in seniors experiencing falls at FPPs (N = 25)* to assess cognitive functioning

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