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Platelet Dopamine Uptake in Huntington's Chorea and Gilles de la Tourette's Syndrome: Effect of Haloperidol

Published online by Cambridge University Press:  18 September 2015

Roger F. Butterworth ,
Michel Gonce  and
André Barbeau
Roger F. Butterworth
Affiliation:
Department of Neurology, Clinical Research Institute of Montreal
Michel Gonce
Affiliation:
Department of Neurology, Clinical Research Institute of Montreal
André Barbeau*
Affiliation:
Department of Neurology, Clinical Research Institute of Montreal
*
Department of Neurology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec H2W 1R7
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Uptake of 14C-dopamine by human platelets has been studied in two diseases, namely Gilles de la Tourette's syndrome and Huntington's chorea, in which abnormal metabolism of dopamine has been implicated. Platelets from untreated Huntington's chorea patients showed a small increase in Km and Vmax.; platelets from patients in all other groups showed an uptake identical with the controls. Haloperidol (10 -5M) was also shown to be a strong non-competitive inhibitor of 14C-DA uptake by platelets. This property is probably unrelated to the drugs' action in ameliorating the symptoms of Huntington's chorea which is likely related to the increase in cholinergic neuronal activity produced by neuroleptic blockade of dopamine receptors.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 4 , Issue 4 , November 1977 , pp. 285 - 288
Copyright
Copyright © Canadian Neurological Sciences Federation 1977

References

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