Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-04T18:13:05.475Z Has data issue: false hasContentIssue false

Pediatric Pseudotumor Cerebri: Descriptive Epidemiology

Published online by Cambridge University Press:  18 September 2015

Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Objective:

To determine the epidemiological profile for pediatric pseudotumor cerebri.

Methods:

A retrospective case series was identified from a geographically limited region of 205,765 children aged 2-15 years at the only tertiary care pediatric hospital with all pediatric neurologists and ophthalmologists. Health records identified 35 children with ICD9 code 348.2 (benign intracranial hypertension) presenting between April 1, 1979 and March 31, 1994. After chart review, 29 cases were identified which satisfied modified Dandy's diagnostic criteria for pseudotumor cerebri.

Results:

The 29 cases ranged in age from 3-15 years. The annual incidence of symptomatic disease was 0.9 per 100,000 children (95% Cl 0.6, 1.4). Cases were 2.7 times more likely to be female (21/29, X² p = .01) and twice as likely to be adolescent (age 12-15 years), (X² p = .04). Based upon these distinctions, the following estimates of age and sex specific disease incidence were derived (based upon 100,000 child years of exposure): male age 2-11 years: 0.4; male age 12-15 years: 0.8; female age 2-11 years: 1.1; female age 12-16 years: 2.2.

Conclusions:

These data appear to be unique for its the estimation of age and sex specific incidence rates for pediatric pseudotumor cerebri.

Type
Original Articles
Copyright
Copyright © Canadian Neurological Sciences Federation 1997

References

REFERENCES

1.Smith, JL. Whence pseudotumor cerebri? J Clin Neuro-Opthalmol 1985; 5: 5556.Google Scholar
2.Statistics Canada. The Nation: Age, Sex and Marital Status. Ottawa: Supply and Services Canada, 1987.Google Scholar
3.Fleiss, JL. Statistical methods for rates and proportions. New York: John Wiley & Sons, 1981.Google Scholar
4.Dean, AG, Dean, JA, Coulombier, D, et al. Epi Info, Version 6: A word processing, database, and statistics program for epidemiology on microcomputers. Centers for Disease Control and Prevention, Atlanta, Georgia, USA, 1994.Google Scholar
5.Dibley, MJ, Goldsby, JB, Staehling, NW, et al. Development of normalized curves for the international growth reference: historical and technical considerations. Am J Clin Nutr 1987; 46: 736748.CrossRefGoogle ScholarPubMed
6.Radhakrishnan, K, Ahlskog, JE, Cross, SA. Idiopathic intracranial hypertension (pseudotumor cerebri). Arch Neurol 1993; 50: 7880.Google Scholar
7.Durcan, FJ, Corbett, JJ, Wall, M. The incidence of pseudotumor cerebri: population studies in Iowa and Louisiana. Arch Neurology 1988; 45: 875877.Google Scholar
8.Rush, JA. Pseudotumor cerebri (clinical profile and visual outcome in 63 patients). Mayo Clin Proc 1980; 55: 541546.Google Scholar
9.Wall, M, George, D. Idiopathic intracranial hypertension. Brain 1991; 114: 155180.Google Scholar
10.Boeri, R. The pseudotumor cerebri. Curr Opinion Neurol 1994; 7: 6973.CrossRefGoogle ScholarPubMed
11.Grant, DN. Benign intracranial hypertension. Arch Dis Child 1971; 46: 651655.CrossRefGoogle ScholarPubMed
12.Rose, A, Matson, DD. Benign intracranial hypertension in children. Pediatrics 1967; 39: 227237.CrossRefGoogle ScholarPubMed
13.Weisberg, JA, Chutorian, AM. Pseudotumor cerebri of childhood. Am J Dis Child 1977; 131: 1243-–1248.Google ScholarPubMed
14.Hagberg, B, Sillanpaa, M. Benign intracranial hypertension (pseudotumor cerebri). Acta Pediatr Scand 1970; 59: 328339.CrossRefGoogle ScholarPubMed
15.Babikian, P, Corbett, J, Bell, W. Idiopathic intracranial hypertension in children: the Iowa experience 1994; 9: 144149.Google ScholarPubMed
16.Lessel, S. Pediatric pseudotumor cerebri (idiopathic intracranial hypertension). Surv Opthalmol 1992; 37: 155166.Google Scholar
17.Forbes, GB. Nutrition and growth. J Pediatr 1977; 91: 4042.Google Scholar
18.Garn, SM, Clark, DC, Guire, KE. Level of fatness and size attainment. Am J Phys Anthropol 1973; 40: 447449.Google Scholar
19.Sargent, JD, Blanchflower, DG. Obesity and stature in adolescence and earnings in young adulthood: analysis of a British birth cohort. Arch Pediatr Adolesc Med 1994; 148: 681687.CrossRefGoogle ScholarPubMed
20.Ireland, B, Corbett, JJ, Wallace, RB. The search for causes of idiopathic intracranial hypertension: a preliminary case-control study. Arch Neurol 1990; 47: 315320.CrossRefGoogle ScholarPubMed
21.Giuseffi, V, Wall, M, Seigel, PZ, Rojas, PB. Symptoms and disease associations in idiopathic intracranial hypertension (pseudotumor cerebri): a case-control study. Neurology 1991; 41: 239244.Google Scholar
22.Couch, R, Camfield, PR, Tibbies, JAR. The changing picture of pseudotumor cerebri in children. Can J Neurol Sci 1985; 12: 48Google Scholar