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Pathophysiology and Pharmacotherapy of Spasmodic Torticollis: A Review

Published online by Cambridge University Press:  18 September 2015

S. Lal
S. Lal*
Affiliation:
Department of Psychiatry, Montreal General Hospital, Montreal
*
Department of Psychiatry, Montreal General Hospital, 1650 Cedar Street, Montreal, Quebec H3G 1A4, Canada
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Summary:

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The few existing neuropathological, neurochemical, and neuropharacological studies have shed little light on the pathophysiology of spasmodic torticollis (ST). The relevance of experimental ST in animals and drug-induced ST in man to idiopathic ST is unclear.

Most pharmacotherapeutic endeavors have focused on drugs affecting basal ganglia function. Unfortunately, problems of sample size, clinical heterogeneity of patient population, research design, objective evaluation of response, documentation of key data, and adequacy of duration of follow-up make interpretation of published results difficult. Because of the heterogeneity of ST, investigations aimed at establishing a neurotransmitter profile for each patient by observing the acute response to a test dose of drugs affecting cholinergic, dopaminergic, serotonergic, and gammaaminobutyric acid systems may provide a more rational basis to the selection of treatment.

Type
Review Article
Information
Canadian Journal of Neurological Sciences , Volume 6 , Issue 4 , November 1979 , pp. 427 - 435
Copyright
Copyright © Canadian Neurological Sciences Federation 1979

References

Alpers, B.J. and Drayer, C.S. (1937). The organic background of some cases of spasmodic torticollis. Report of a case with autopsy. Am. J. Med. Sci., 193, 378–384.CrossRefGoogle Scholar
Ansari, K.A. and Webster, D.D. (1974). Quantitative measurements in spasmodic torticollis. Dis. Nerv Syst., 35, 44–47.Google ScholarPubMed
Ansari, K.A., Webster, D. and Manning, N. (1972). Spasmodic torticollis and L-dopa. Results of therapeutic trial in six patients. Neurology, 22, 670–674.CrossRefGoogle ScholarPubMed
Avman, N. and Arasil, E. (1969). Spasmodic torticollis due to a colloid cyst of the third ventricle. Acta Neurochir. (Wien), 21, 265–268.CrossRefGoogle ScholarPubMed
Ayd, F.J. (1961). A survey of drug-induced extrapyramidal reactions. J. Am. Med. Assoc., 175, 1054–1060.CrossRefGoogle ScholarPubMed
Barbeau, A., Mars, H. and Gillo-Joffroy, L. (1971). Adverse clinical side effects of levodopa therapy. In Recent Advances in Parkinson’s Disease, Edited by McDowell, F.H. and Markham, CH., pp 203–237, F.A. Davis Co, Philadelphia.Google Scholar
Barrett, R E., Yahr, M.D. and Duvoisin, R.C. (1970). Torsion dystonia and spasmodic torticollis-results of treatment with L-dopa. Neurology, 20, Suppl. 107–113.Google Scholar
Battista, A.F., Goldstein, M., Miyamoto, T. and Matsumoto, Y. (1976). Effect of centrally acting drugs on experimental torticollis in monkeys. Adv. Neurol., 14, 329–338.Google ScholarPubMed
Bernhardt, A.J., Hersen, M. and Barlow, D.H. (1972). Measurement and modification of spasmodic torticollis: an experimental analysis. Behav. Therap., 3, 294–297.CrossRefGoogle Scholar
Bianchine, J.R. and Bianchine, J.W. (1971). Treatment of spasmodic torticollis with diazepam. S. Med. J., 64, 893–894-.CrossRefGoogle ScholarPubMed
Bigwood, G.F. (1972). Treatment of spasmodic torticollis. New Engl. J. Med., 286, 1161.Google ScholarPubMed
Blom, S. and Ekbom, K.A. (1961). Comparison between akathisia developing on treatment with phenothiazine derivatives and restless legs syndrome. Acta Med. Scand., 170, 689–694.CrossRefGoogle ScholarPubMed
Boisen, E. (1979). Torticollis caused by an infratentorial tumour. Three cases. Brit. J. Psychiat., 134, 306–307.CrossRefGoogle ScholarPubMed
Brown, W.A., Van Woert, M.H. and Ambani, L.M. (1973). Effect of apomor-phine on growth hormone release in humans. J. Clin. Endocrinol. Metab., 37, 463–465.CrossRefGoogle ScholarPubMed
Bunts, A.T. (1960). The surgical treatment of spasmodic torticollis. Am. Surg., 26, 560–563.Google ScholarPubMed
Carpenter, M.B. (1956). A study of the red nucleus in the rhesus monkey. Anatomical degenerations and physiological effects resulting from localized lesions of the red nucleus. J. Comp. Neurol., 105, 195–249.CrossRefGoogle ScholarPubMed
Carrea, R.M.E. and Mettler, F.A. (1955). Function of the primate brachium conjunctivum and related structures. J. Comp. Neurol., 102, 151–322.CrossRefGoogle ScholarPubMed
Cassirer, R. (1922). Halsmuskelkrampf und Torsionsspasmus. Klin. Wschr., 1, 53–57.CrossRefGoogle Scholar
Casteels-Van Daele, M., Jaeken, J., Van Der Schueren, P., Zimmerman, A. and Van Den Bon, . (1970). Dystonic reactions in children caused by metoclopramide. Arch. Dis. Child., 45, 130–133.CrossRefGoogle ScholarPubMed
Chateau, R., Fau, R., Groslambert, R. and Perret, J. (1966). À propos d’un cas de torticolis spasmodique irréversible, survenu au cours d’un traitement par neuro-leptiques. Rev. Neurol. (Paris), 114, 65–68.Google Scholar
Choppy-Jacolin, M., Ferrey, G. and Demaria, C. (1977). A psychometric study of 34 patients afflicted with spasmodic torticollis. Acta Neurol, Scand., 55,483–492.CrossRefGoogle ScholarPubMed
Cockburn, J.J. (1971). Spasmodic torticollis: a psychogenic condition? J. Psycho-somat. Res., 15, 471–477.CrossRefGoogle ScholarPubMed
Cottom, D.G. and Newman, C.G.H. (1966). Dystonic reactions to phenothiazine derivatives. Arch. Dis. Child., 41, 551–553.CrossRefGoogle ScholarPubMed
Couch, J.R. (1976a). General discussion of drug-therapy in dystonia. Adv. Neurol., 14, 417–422.Google Scholar
Couch, J.R. (1976b). Dystonia and tremor in spasmodic torticollis. Adv. Neurol., 14, 245–258.Google ScholarPubMed
Couper-Smartt, J. (1973). Lithium in spasmodic torticollis. Lancet, 2, 741–742.CrossRefGoogle ScholarPubMed
Critchley, M. (1939). Spastic dysphonia (“inspiratory speech”). Brain, 62, 96–103.CrossRefGoogle Scholar
Crossman, A.R. and Sambrook, M.A. (1978). Experimental torticollis in the monkey produced by unilateral 6-hydroxy-dopamine brain lesions. Brain Res., 149, 498–502.CrossRefGoogle ScholarPubMed
Curzon, G. (1973). Involuntary movements other than Parkinsonism: biochemical as-pects. Proc. Roy. Soc. Med. 66, 29–32.Google Scholar
David, M., Hecaen, H. and Constans, J. (1952). Torticolis spasmodique consécutif à une lésion corticale traumatique. Discussion du résultat favorable obtenu après excision de la lésion corticale. Rev. Neurol. (Paris), 86, 57–61.Google Scholar
Denny-Brown, D. (1962). The midbrain and motor integration. Proc. Roy. Soc. Med., 55, 527–538.CrossRefGoogle ScholarPubMed
Dimascio, A., Bernado, D.L.Green-Blatt, D.J. and Marder, J.E. (1976) A controlled trial of amantadine in drug-induced extrapyramidal disorders. Arch. Gen. Psychiat., 33, 599–602.CrossRefGoogle ScholarPubMed
Emile, J., Bastard, J. and Truelle, J-L. (1977). Utilisation du tiapride en neurologie. Résultats préliminaires. Sem. Hôp. (Paris), 53, 16–20.Google Scholar
Fabing, H.D. (1954). Alpha-(2-piperidyl) benzhydrol hydrochloride, a new central stimulant, in the treatment of blepharospasm, spasmodic torticollis and narcolepsy. Tran. Am. Neurol. Ass., 79, 159–163.Google Scholar
Fann, W.E. (1966). Use of methylphenidate to counteract acute dystonic effects of pheno-thiazines. Am. J. Psychiat., 122, 1293–1294.CrossRefGoogle Scholar
Foerster, O. (1933). Mobile spasm of the neck muscles and its physiological basis. J. Comp. Neurol. 58: 725–735.CrossRefGoogle Scholar
Foltz, E.L., Knopp, L.M. and Ward, A.A. (1959). Experimental spasmodic torticollis. J. Neurosurg., 16, 55–72.CrossRefGoogle ScholarPubMed
Gilbert, G.J. (1971). Spasmodic torticollis treated effectively by medical means. New Engl. Med. J., 284, 896–898.CrossRefGoogle ScholarPubMed
Gilbert, G.J. (1972a). The medical treatment of spasmodic torticollis Arch. Neurol., 27, 503–506.Google Scholar
Gilbert, G.J. (1972b). Haloperidol in spasmodic torticollis. Lancet, 2, 234–235.CrossRefGoogle ScholarPubMed
Gilbert, G.J. (1972c). Treatment of spasmodic torticollis. New Engl. J. Med., 286, 1161–1162.Google Scholar
Gilbert, G.J. (1977a). Familial spasmodic torticollis. Neurology, 27, 11–13.CrossRefGoogle ScholarPubMed
Gilbert, G.J. (1977b). Treatment questioned in familial spasmodic torticollis. Reply from the author. Neurology, 27, 900.CrossRefGoogle Scholar
Grinker, R.R. and Walker, A.E. (1933). The pathology of spasmodic torticollis with a note on respiratory failure from anesthesia in chronic encephalitis. J. Nerv. Ment. Dis., 78, 630–637.CrossRefGoogle Scholar
Gupta, J.M. and Lovejoy, F.H. (1967). Acute phenothiazine toxicity in childhood: a five-year survey. Pediatrics, 39, 771–774.CrossRefGoogle ScholarPubMed
Harenko, A. (1967). Retrocollis as an irreversible late complication of neuroleptic medication. Acta Neurol. Scand. 43, Suppl. 31: 145–146.CrossRefGoogle ScholarPubMed
Hassin, G.B. (1939). Quinine and dystonia musculorum deformans. J. Am. Med. Assoc., 113, 12–14.CrossRefGoogle Scholar
Hassler, R. and Diekmann, G. (1970). Stereotactic treatment of different kinds of spasmodic torticollis. Confin. Neurol. 32, 135–143.CrossRefGoogle ScholarPubMed
Herz, E. and Glaser, G.H. (1949). Spasmodic torticollis. II. Clinical evaluation. Arch. Neurol. Psychiat. 61, 227–239.CrossRefGoogle Scholar
Hirschmann, J. and Mayer, K. (1964). Zur Beeinflussung der Akinese und anderer extrapyramidal-motorischer Storungen mit L-Dopa (L-Dihydroxyphenylalanin). Deutsch. Med. Wschr., 89, 1877–1880.CrossRefGoogle Scholar
Johansson, B. and Roos, B-E. (1974). 5-Hydroxyindoleacetic acid and homovanillic acid in cerebrospinal fluid of patients with neurological diseases. Europ. Neurol., 11, 37–45.CrossRefGoogle Scholar
Kjellin, KG. and Stibler, H. (1975). Cerebrospinal fluid protein patterns in spasmodic torticollis. Europ. Neurol., 13, 461–475.CrossRefGoogle ScholarPubMed
Korein, J. (1977). Treatment questioned in familial spasmodic torticollis. Neurology, 27, 899–900.CrossRefGoogle ScholarPubMed
Krebs, M.E. (1939). Note sur le traitement pratiqué dans un cas de torticolis spasmo-dique. Rev. Neurol. (Paris), 71, 423–424.Google Scholar
Lal, S., Hoyte, K.M., Kiely, M.E., Sourkes, T.L., Baxter, D.W., Missala, K. and Andermann, F. (1979). Neuropharmacological investigation and treatment of spasmodic torticollis. Adv. Neurol, (in press).Google ScholarPubMed
Laterre, E.C. and Fortemps, E. (1975). Deanol in spontaneous and induced dyskinesias. Lancet, 1, 1301.CrossRefGoogle ScholarPubMed
Lees, A., Shaw, K.M. and Stern, G.M. (1976). Bromocriptine and spasmodic torti-collis. Brit. Med. J., 1, 1343.CrossRefGoogle Scholar
Markham, CH., Clark, W.G. and Winters, W.D. (1963). Effect of alpha-methyl dopa and reserpine in Huntington’s chorea, Parkinson’s disease and other movement disorders. Life Sci., 9, 697–705.CrossRefGoogle ScholarPubMed
Marsden, CD., Tarsy, D. and Bald-Essarini, R.J. (1975). Spontaneous and drug-induced movement disorders in psychotic patients. In Psychiatric Aspects of Neurologic Disease, Edited by Benson, D.F. and Blumer, D., pp 219–266,Grune andStratton, New York.Google Scholar
Marsden, CD. (1976). The problem of adult-onset idiopathic torsion dystonia and other isolated dyskinesias in adult life (including blepharospasm, oromandibular dystonia, dystonic writer’s cramp, and torticollis or axial dystonia. Adv. Neurol. 14, 259–276.Google ScholarPubMed
Mathews, W.B., Beasley, P., Parry-Jones, W. and Garland, G. (1978). Spasmodic torticollis: a combined clinical study. J. Neurol. Neurosurg. Psychiat., 41, 485–492.CrossRefGoogle Scholar
Meares, R. (1971). Natural history of spasmodic torticollis and effect of surgery. Lancet, 2, 149–151.CrossRefGoogle ScholarPubMed
Mori, K., Fujita, Y., Shimabukuro, H., Ito, M. and Handa, H. (1975). Some considerations for treatment of spasmodic torticollis. Clinical and experimental studies. Confin. Neurol. 37, 265–269.CrossRefGoogle ScholarPubMed
Myerson, A. and Loman, J. (1942). Amphetamine sulfate in treatment of spasmodic torticollis. Arch. Neurol. Psychiat., 48, 823–828.CrossRefGoogle Scholar
Papeschi, R., Molina-Negro, P., Sourkes, T.L. and Erba, G. (1972). The concentration of homovanillic acid and 5-hydroxyindoleacetic acid in ventricular and lumbar CSF. Neurology, 22,1151–1159.CrossRefGoogle ScholarPubMed
Patteron, R.M. and Little, S.C. (1943). Spasmodic torticollis. 98, 571–599.Google Scholar
Pernikoff, M. (1964). Treatment of acute and chronic muscle spasm with diazepam. Clin. Med. 71, 699–705.Google ScholarPubMed
Podvinsky, F. (1969). Role of sensory and emotional inputs in mechanisms underlying involuntary motor activity. Modern concepts of torticollis. 1. Electromyographic analysis. Activ. Nerv. Sup. 11, 11–29.Google Scholar
Poirier, L.J. (1960). Experimental and histological study of midbrain dyskinesias. J. Neurophysiol., 23, 534–551.CrossRefGoogle ScholarPubMed
Poppen, J.L. and Martinez-Niochet, A. (1951). Spasmodic torticollis. Surg. Clin. N. Amer., 31, 883–890.CrossRefGoogle Scholar
Putnam, T.J., Herz, E. and Glaser, G.H. (1949). Spasmodic torticollis. 111. Surgical treatment. Arch. Neurol. Psychiat. 61, 240–247.CrossRefGoogle Scholar
Shaw, K.M., Hunter, K.R. and Stern, G.M. (1972). Medical treatment of spasmodic torticollis. Lancet, 1, 1399.CrossRefGoogle ScholarPubMed
Sigwald, J., Bouttier, D., Mme, CAILLE and Gineset, D. (1959). Deux cas de syndrome dystonique et dyskinétique cervico-céphalique (torticolis spasmodique, retrocolis) transformé par le 2 bismethane sulfonate de diméthylsulfamido-3 [(méthyl-4 “piperazinyl-l”) -3 propyl] -10 phénothia-zine (7843RP). Rev. Neurol. (Paris), 100, 778–780.Google Scholar
Sigwald, J. and Raymondeaud, C. (1970). Les mouvements anormaux observés au cours du traitement de la maladie de Parkinson par la L-dopa. Rev. Neurol. (Paris), 122, 103–112.Google Scholar
Swash, M., Roberts, A H., Zakko, H. and Heathfield, K.W.G. (1972). Treatment of involuntary movement disorders with tetrabenazine. J. Neurol. Neurosurg. Psychiat., 35, 186–191.CrossRefGoogle ScholarPubMed
Swett, C. (1975). Drug-induced dystonia. Am. J. Psychiat., 132, 532–534.Google ScholarPubMed
Tarlov, E. (1970). On the problem of pathology of spasmodic torticollis in man. J. Neurol. Neurosurg. Psychiat., 33, 457–463.CrossRefGoogle ScholarPubMed
Tolosa, E.S. (1978). Modification of tardive dyskinesia and spasmodic torticollis by apomorphine. Arch. Neurol., 35, 459–462.CrossRefGoogle Scholar
Trillet, M., Joyeux, O. and Masson, R. (1977). Tiapride et mouvements anormaux. Sem. Hôp. (Paris), 53, 21–27.Google Scholar
Turner, S.M., Hersen, M. and Alford, H. (1974). Effects of massed practice and meprobamate on spasmodic torticollis: an experimental analysis. Behav. Ther., 12, 259–260.CrossRefGoogle ScholarPubMed
Urechia, C.I. and Mme, RETEZEANU (1937). Parkinsonisme avec torticolis spas-modique ou avec tics buccaux. Arch. Neurol. (Paris), 56, 491–494.Google Scholar
West, H.H. (1977). Treatment of spasmodic torticollis with amantadine: a double-blind study. Neurology, 27, 198–199.CrossRefGoogle ScholarPubMed
Wimmer, A. (1929). Le spasme de torsion. Rev. Neurol. (Paris), 1, 904–915.Google Scholar
Winther, K. (1930). Tumeur du quatrième ventricule, se manifestant seulement par une deviation de la tÊte. Acta Psychiat. Neurol., 5, 45–53.CrossRefGoogle Scholar