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The Neurotoxicity of 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine in the Monkey and Man

Published online by Cambridge University Press:  18 September 2015

R. Stanley Burns ,
Sanford P. Markey ,
Jere M. Phillips  and
Chuang C. Chiueh
Sanford P. Markey
Affiliation:
Section on Analytical Biochemistry, Laboratory of Clinical Sciences, National Institute of Mental Health, Bethesda, Maryland
Jere M. Phillips
Affiliation:
Section on Laboratory Animal Medicine and Care, National Institute of Mental Health, Bethesda, Maryland
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Abstract

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l-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) selectively destroys dopaminergic neurons in the pars compacta of the substantia nigra (A8 and A9 cells). MPTP or its metabolite enters nerve cells at the level of their terminals in the caudate nucleus and putamen leading to a disturbance in axoplasmic flow and retrograde degeneration. The species-dependent neurotoxicity of MPTP (primate vs. rodent) suggests that a biochemical property of the cell related to neuromelanin may be important in the mechanism of cell injury.

Type
4. Toxic Environmental Factors Causing Parkinsonism
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue S1: Current Concepts and Controversies in Parkinson’s Disease , February 1984 , pp. 166 - 168
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

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