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Myotonic Dystrophy: An Electrophysiological Study of Cognitive Deficits

Published online by Cambridge University Press:  18 September 2015

Aldo Ragazzoni ,
Francesco Pinto ,
Rosanna Taiuti  and
Maria Caterina Silveri
Aldo Ragazzoni
Affiliation:
Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
Francesco Pinto*
Affiliation:
Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
Rosanna Taiuti
Affiliation:
Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
Maria Caterina Silveri
Affiliation:
he Institute of Neurology, Catholic University, Rome, Italy
*
Dipartimento di Scienze Neurologiche e Psichiatrich, Universita' di Firenze, Viale Morgagni, 85 50126 Firenze, Italy
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Abstract:

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Patients with Myotonic Dystrophy (MyD) frequently suffer from a dysfunction of the primary sensory pathways, as documented by abnormalities of short-latency evoked potentials. Impairment of intellectual functions has been less extensively investigated. Short-latency brainstem auditory evoked potentials (BAEPs) as well as long-latency auditory event-related potentials (ERPs) were recorded from 5 female and 6 male patients affected by MyD. A simple discrimination (“oddball”) paradigm was used to record ERPs to tones from Fz, Cz, Pz. Both BAEPs and ERPs were significantly altered as compared to normals. BAEP abnormalities were detected in 9 patients and ERP components N2 and P3 were delayed or absent for all patients, who nonetheless correctly discriminated between tones. These data indicate that CNS dysfunction in MyD involves not only primary sensory systems but also neural mechanisms underlying cognitive events and ERP generation.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue 3 , August 1991 , pp. 300 - 306
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

References

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