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MPTP-Induced Neurotoxicity and the Quest for a Preventative Therapy for Parkinson's Disease

Published online by Cambridge University Press:  18 September 2015

J.C.S. Furtado  and
Michael F. Mazurek
J.C.S. Furtado
Affiliation:
Division of Neuroscience, Department of Biomedical Sciences, McMaster University Medical Centre, Hamilton
Michael F. Mazurek*
Affiliation:
Division of Neuroscience, Department of Biomedical Sciences, McMaster University Medical Centre, Hamilton Division of Neurology, Department of Medicine, McMaster University Medical Centre, Hamilton
*
Neurology 4U2, McMaster University, Medical Centre, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
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Abstract:

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Less than 10 years have passed since the discovery that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is capable of producing parkinsonism in both humans and non-human primates. In that time, there has been considerable interest in the possibility that the pathogenesis of idiopathic Parkinson's disease (PD) might involve a process analogous to that of MPTP toxicity. One hypothesis holds that PD might arise, at least in part, from exposure to an MPTP-like environmental toxin. Rapid progress has been made towards elucidating the precise mechanism by which MPTP exerts toxicity, and clarifying the relationship of MPTP toxicity to idiopathic PD. The goal of these efforts is to develop a therapy that inhibits the underlying disease process in PD.

Type
Focus on Parkinson's Disease
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue 1 , February 1991 , pp. 77 - 82
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

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