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Modulation of Monoaminergic and Amino Acid Transmission as a Means for Therapeutic Intervention in Ataxia

Published online by Cambridge University Press:  18 September 2015

Plaitakis Andreas
Plaitakis Andreas*
Affiliation:
Mount Sinai School of Medicine, New York
*
Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York, USA 10029
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Abstract:

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In recent years, substantial progress has been made in understanding the organization and function of the cerebellum at the neuronal, synaptic, and molecular level. More than any other region of the brain, the cerebellum utilizes amino acids as its main excitatory and inhibitory transmitters. Excitatory amino acids, such as glutamate and aspartate, in addition to serving as chemical messengers, may also mediate neurodegenerative processes in human ataxic disorders. Of the monoamines, serotonin has been proposed as a neuromodulator in the cerebellum and is thought to play a role in the pathophysiology of ataxia in animal models, and human cerebellar disorders. These considerations raise the possibility that pharmacologic modification of amino acid and serotonergic transmission may provide a means for therapeutic intervention in ataxia.

Type
Abstract
Information
Canadian Journal of Neurological Sciences , Volume 20 , Issue S3 , May 1993 , pp. S105 - S108
Copyright
Copyright © Canadian Neurological Sciences Federation 1993

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