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Meta-Analysis of Aldehyde Dehydrogenase 2 Gene Polymorphism and Alzheimer's Disease in East Asians

Published online by Cambridge University Press:  02 December 2014

Pan-Pan Hao ,
Yu-Guo Chen ,
Jia-Li Wang ,
Xing Li Wang  and
Yun Zhang
Pan-Pan Hao
Affiliation:
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, China
Yu-Guo Chen*
Affiliation:
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, China
Jia-Li Wang
Affiliation:
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, China
Xing Li Wang
Affiliation:
Division of Cardiothoracic Surgery, The Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
Yun Zhang*
Affiliation:
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, China
*
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, No. 107, Wen Hua Xi Road, Jinan 250012, China. Pan-Pan Hao and Jia-Li contributed to this work equally.
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, No. 107, Wen Hua Xi Road, Jinan 250012, China. Pan-Pan Hao and Jia-Li contributed to this work equally.
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Abstract

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Background:

The association of genetic polymorphism of mitochondrial aldehyde dehydrogenase 2 (ALDH2) and Alzheimer's disease (AD) has been controversial and has been investigated only in several small-sample studies. In the present study, we performed a meta-analysis to evaluate the cross-sectional association of ALDH2 variants and AD risk in East Asian populations.

Methods:

Trials were retrieved through MEDLINE, EMBASE, J-STAGE and the China National Knowledge Internet databases (from January 1, 1994 to November 1, 2010) without any restriction on language. Data were abstracted by a standardized protocol.

Results:

We found four studies of 821AD patients and 1380 healthy controls that qualified for the analysis. The variant ALDH2 genotype GA/AA was not associated with increased AD risk (odds ratio (OR) = 1.35; 95% confidence interval (CI) = 0.75-2.42; p = 0.32), even after stratification for the status of apolipoprotein E epsilon 4 allele. However, in the subgroup analyses, the association was significant for men (OR = 1.72; 95% CI = 1.10-2.67; p = 0.02).

Conclusions:

This study adds to the evidence that ALDH2 GA/AA genotype increases the risk of AD among East Asian men, although the effect size is moderate.

Résumé:

Résumé:Contexte:

L’association entre le polymorphisme du gene de l’aldehyde deshydrogenase 2 (ALDH2) et la maladie d’Alzheimer (MA) est controversee et elle a ete examinee seulement au cours d’etudes faites chez un petit nombre de sujets. Nous avons effectue une meta-analyse pour evaluer l’association transversale de variations dans le gene de l’ALDH2 et le risque de MA dans des populations de l’Asie de l‘Est.

Méthode:

Nous avons identifie les etudes dans MEDLINE, EMBASE, J-STAGE et dans les bases de donnees de China National Knowledge Internet, du 1er janvier 1994 au 1er novembre 2010, sans restriction quant a la langue de publication. Les donnees ont ete recueillies selon un protocole standardise.

Résultats:

Nous avons identifie 4 etudes portant sur un total de 821 patients atteints de MA et 1380 temoins en bonne sante, qui rencontraient les criteres etablis pour l’analyse. La variante genotypique GA/AA du gene de l’ALDH2 n’etait pas associee a un risque accru de MA(RC = 1,35; IC a 95% : 0,75 a 2,42; p = 0,32), meme apres ajustement pour la presence de l’allele epsilon 4 du gene de l’apolipoproteine E. Cependant, dans les analyses de sous-groupes, l’association etait significative chez les hommes (RC = 1,72 ; IC a 95% : 1,10 a 2,67; p = 0,02).

Conclusions:

Cette etude appuie la notion que le genotype GA/AA du gene de l’ALDH2 augmente le risque de MA chez les hommes de l’Asie de l‘Est, mais que cet effet est modere.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 38 , Issue 3 , May 2011 , pp. 500 - 506
Copyright
Copyright © The Canadian Journal of Neurological 2011

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