Hostname: page-component-745bb68f8f-s22k5 Total loading time: 0 Render date: 2025-01-24T05:08:45.153Z Has data issue: false hasContentIssue false
  • English
  • Français

Kindling, Unit Discharge Patterns and Neural Plasticity

Published online by Cambridge University Press:  18 September 2015

Ronald Racine ,
Larry Tuff  and
Josef Zaide
Ronald Racine*
Affiliation:
Department of Psychology, McMaster University, Hamilton, Ontario
Larry Tuff
Affiliation:
Department of Psychology, McMaster University, Hamilton, Ontario
Josef Zaide
Affiliation:
Department of Psychology, McMaster University, Hamilton, Ontario
*
Department of Psychology, McMaster University, Hamilton, Ontario, Canada
Rights & Permissions [Opens in a new window]

Summary:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Two approaches to the study of the kindling phenomenon were discussed: 1) an attempt to identify the pattern of neural activity required to produce the changes underlying kindling and 2) an investigation into the nature of those changes. Three experiments were reported that used the neocortical transcallosal system as a monosynaptic model system in which to study possible synaptic mechanisms of the kindling effect. Experiment I showed an increase in the transcallosal evoked potential following neocortical kindling. Experiment II showed an increase in the strength of the transcallosal evoked cell discharge following neocortical kindling. Experiment III reported the results of an histological examination of neocortical tissue in kindled and non-kindled animals using the Golgi-Cox technique. Spine density, spine dimension and branching were measured for pyramidal cell apical dendrites. No differences were found between primary and secondary (contralateral) foci or between kindled and non-kindled animals.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 2 , Issue 4 , November 1975 , pp. 395 - 405
Copyright
Copyright © Canadian Neurological Sciences Federation 1975

References

REFERENCES

Adamec, R. (1973) The neural basis of prolonged inhibition of predatory attack in the domestic cat. Unpublished doctoral dissertation. McGill University, Montreal.Google Scholar
Arnold, P., Racine, R. and Wise, R. (1973). Effects of atropine, reserpine, 6-hydroxydopamine, and handling on seizure development in the rat. Experimental Neurology, 40, 457–470.CrossRefGoogle ScholarPubMed
Azcurra, J. and DeRobertis, E. (1967). Binding of dimethyl-C14-D-tubocurarine, methyl-C14-hexamethonium and H3-alloferine by isolated synaptic membranes of brain cortex, International Journal of Pharmacology, 6, 15–26.Google ScholarPubMed
Bliss, T. and Gardner-Medwin, A. (1973). Long lasting potentiation of synaptic transmission in the dentate area of the unanesthetized rabbit following stimulation of the perforant path. Journal of Phsyiology, 232, 357–374.Google Scholar
Burnham, W. (1971). Epileptogenic modification of the rat forebrain by direct and trans-synaptic stimulation. Unpublished doctoral dissertation. McGill University, Montreal.Google Scholar
Coleman, P. and Riesen, A. (1968). Environmental effects of cortical dendrite fields. I. Rearing in the dark. Journal of Anatomy, 102, 363–374.Google Scholar
Cragg, B. (1967). Changes in visual cortex on first exposure of rats to light. Nature, 215, 251–253.CrossRefGoogle ScholarPubMed
Curtis, H. (1940). Intercortical connections of corpus callosum as indicated by evoked potentials. Journal of Neurophysiology, 3, 407–413.CrossRefGoogle Scholar
Delgado, J. and Sevillano, M. (1961). Evolution of repeated hippocampal seizures in the cat. Electroencephalography and Clinical Neurophysiology, 13, 722–733.CrossRefGoogle Scholar
Douglas, R. and Goddard, G. (1975). Long term potentiation of the perforant path-granule cell synapse in the rat hippocampus. Brain Research. In press.CrossRefGoogle ScholarPubMed
Globus, A., Rosensweig, M., Bennett, E. and Diamond, M. (1973). Effects of differential experience on dendritic spine counts. Journal of Comparative and Physiological Psychology, 82, 175–181.CrossRefGoogle ScholarPubMed
Goddard, G. (1972). Long term alteration following amygdaloid stimulation. In: (Eleftherious, B., Ed.). The neurobiology of the amygdala. Plenum, New York, pp. 581–596.CrossRefGoogle Scholar
Goddard, G., McIntyre, D. and Leech, C. (1969). A permanent change in brain function resulting from daily electrical stimulation. Experimental Neurology, 25, 295–330.CrossRefGoogle ScholarPubMed
Goddard, G. and Morrell, F. (1971). Chronic progressive epileptogenesis induced by focal electrical stimulation of brain. Neurology, 21, 393.Google Scholar
Greenough, W. and Volkmar, F. (1973). Pattern of dendritic branching in occipital cortex of rats reared in complex environments. Experimental Neurology, 40, 491–504.CrossRefGoogle ScholarPubMed
Heimer, L., Ebner, F. and Nauta, W. (1967). A note on the termination of commissural fibers in the neocortex. Brain Research, 5, 171.CrossRefGoogle ScholarPubMed
Halloway, R. (1966). Dendritic branching: Some preliminary results of training and complexity in rat visual cortex. Brain Research, 2, 393–396.CrossRefGoogle Scholar
Jasper, H., Ward, A. and Pope, A. (Eds.) (1969). Basic Mechanisms of the epilepsies. Little, Brown, and Co., Boston.Google Scholar
Krieg, W. (1946). Connections of the cerebral cortex. I. The albino rat. A. Topography of the cortical areas. Journal of Comparative Neurology, 84, 221–275.CrossRefGoogle Scholar
Møllgaard, K., Diamond, M., Bennett, E., Rosenzweig, M. and Lindner, B. (1971). Quantitative synaptic changes with differential experience in rat brain. International Journal of Neurosciences, 2, 113–128.CrossRefGoogle ScholarPubMed
Moore, R., Björklund, A. and Stenevi, U. (1974). Growth and plasticity of adrenergic neurons. In: (Schmitt, F. and Worden, F., eds.). The neurosciences — third study program. MIT press, Boston, pp. 961–977.Google Scholar
Morrell, F. (1973). Goddard’s kindling phenomenon: A new model of the “mirror focus”. In: (Sabelli, H., ed.). Chemical modulation of brain function. Raven Press, New York, pp. 207–224.Google Scholar
Paton, W. and Waud, D. (1967). The margin of safety of neuromuscular transmission. Journal of Physiology, 191, 59–90.CrossRefGoogle ScholarPubMed
Racine, R. (1972a). Modification of seizure activity by electrical stimulation: I. Afterdischarge threshold. Electroencephalography and Clinical Neurophysiology, 32, 281–294.CrossRefGoogle Scholar
Racine, R. (1972b). Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalography and Clinical Neurophysiology, 32, 281–294.CrossRefGoogle ScholarPubMed
Racine, R. (1975). Modification of seizure activity by electrical stimulation: Cortical areas. Electroencephalography and Clinical Neurophsyiology, 38, 1–12.CrossRefGoogle ScholarPubMed
Racine, R., Burnham, W. and Gartner, J. (1973). First trial motor seizures triggered by amygdaloid stimulation in the rat. Electroencephalography and Clinical Neurophysiology, 35, 487–494.CrossRefGoogle ScholarPubMed
Racine, R., Gartner, J. and Burnham, W. (1972). Epileptiform activity and neural plasticity in limbic structures. Brain Research, 47, 262–268.CrossRefGoogle ScholarPubMed
Racine, R., Newberry, F. and Burnham, W. (1975). Post-activation potentiation and the kindling phenomenon. Electroencephalography and Clinical Neurophysiology (In press).CrossRefGoogle ScholarPubMed
Raisman, G. (1969). Neuronal plasticity in the septal nuclei of the adult rat. Brain Research, 14, 25–48.CrossRefGoogle ScholarPubMed
Roberts, L. and Wright, M. (1974). Operant autonomic conditioning in paralyzed rats. Technical report No. 60. Department of Psychology, McMaster University, Hamilton, Ontario.Google Scholar
Ruttledge, L., Wright, C. and Duncan, J. (1974). Morphological changes in pyramidal cells of mammalian cerebral cortex associated with increased use. Experimental Neurology, 44, 209–228.CrossRefGoogle Scholar
Scheibel, M. and Scheibel, A. (1970). Of pattern and place in dendrites. International Review of Neurobiology, 13, 1–26.CrossRefGoogle Scholar
Schwartzbaum, J. and Kreinick, C. (1973). Interrelationships-of hippocampal electroencephalogram, visually evoked response, and behavioural reactivity to photic stimuli in rats. Journal of Comparative and Physiological Psychology, 85, 479–490.CrossRefGoogle ScholarPubMed
Tanaka, A. (1972). Progressive changes of behavioral and electroencephalographic responses to daily amygdaloid stimulation in rabbits. Fukuoka Acta Medica, 63, 152–164.Google Scholar
Tress, K. and Herberg, L. (1972). Permanent reduction in seizure threshold resulting from repeated electrical stimulation. Experimental Neurology, 32, 347–359.CrossRefGoogle Scholar
Vanderwolf, C. (1971). Limbicdiencephalic mechanisms of voluntary movement. Psychological Review, 78, 83–113.CrossRefGoogle ScholarPubMed
Valverde, F. (1967). Apical dendritic spines of the visual cortex and light deprivation in the mouse. Experimental Brain Research, 3, 337–352.CrossRefGoogle ScholarPubMed
Valverde, F. (1971). Rate and extent of recovery from dark rearing in the mouse. Brain Research, 33, 1–11.CrossRefGoogle ScholarPubMed
West, R. and Greenough, W. (1972). Effect of environmental complexity on cortical synapses of rats: Preliminary results. Behavioral Biology, 7, 279–284.CrossRefGoogle ScholarPubMed