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A History of Multiple Sclerosis Investigations in Canada Between 1850 and 1950

Published online by Cambridge University Press:  23 September 2014

Aravind Ganesh*
Affiliation:
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
Frank W. Stahnisch
Affiliation:
Departments of History and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
*
*Neurology Department, Foothills Medical Centre, 1403 29 Street N.W., Calgary, Alberta, T2N 2T9, Canada. Email: [email protected]
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Abstract

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The medical profession's modern quandaries with Multiple Sclerosis (MS) largely began in 1849, with Friedrich von Frerichs' (1819–1885) early description of the clinical and pathological features of what he termed Hirnsklerose (“brain sclerosis”). This manuscript is an overview of the century of research (1850–1950) that followed the emergence of this clinical entity, with a focus on the hitherto under-explored English Canadian perspective. Using journal articles, reviews, and case studies, this historiographical paper reviews what may be some of the earliest recorded cases of MS in Canada, and outlines the diagnostic challenges that confronted early Canadian physicians in their encounters with MS. Early Canadian attempts to characterize the aetiology and epidemiology of MS and treat it are also discussed. These activities were influenced by developments in the field in Europe and the United States, and helped set the stage for the modern era of immunologic and therapeutic research on MS.

Type
Historical Review
Copyright
Copyright © The Canadian Journal of Neurological 2014

References

1.Compston, A, Coles, A. Multiple sclerosis. Lancet. 2002 359(9313)122131.CrossRefGoogle ScholarPubMed
2.Compston, A, Coles, A. Multiple sclerosis. Lancet. 2008 372(9648)150217.CrossRefGoogle ScholarPubMed
3.Frederikson, S, Kam-Hansen, S. The 150-year anniversary of multiple sclerosis: does its early history give an etiological clue?. Perspect Biol Med. 1989 32(2)23743.CrossRefGoogle Scholar
4.Murray, T. The history of multiple sclerosis: the changing frame of the disease over the centuries. J Neurol Sci. 2009 277 S1S38.CrossRefGoogle ScholarPubMed
5.Lassmann, H. Multiple sclerosis pathology: evolution of pathogenetic concepts. Brain Pathol. 2005 15(3)21722.CrossRefGoogle ScholarPubMed
6.Murray, T. Multiple sclerosis: the history of a disease. 2005 New YorkDemos Medical Publishing 312.Google Scholar
7.Beck, C, Metz, L, Svenson, L, Patten, S. Regional variation of multiple sclerosis prevalence in Canada. Mult Scler. 2005 11(5)5169.CrossRefGoogle ScholarPubMed
8.Medaer, R. Does the history of multiple sclerosis go back as far as the 14th century?. Acta Neurol Scand. 1979 60(3)18992.CrossRefGoogle Scholar
9.Firth, D. The case of Augustus d'Este (1794–1848): the first account of disseminated sclerosis. Proc R Soc Med. 1941 34(7)3814.Google ScholarPubMed
10.Jeilinek, E. Heine's illness: the case for multiple sclerosis. J R Soc Med. 1990 83(8)5169.CrossRefGoogle Scholar
11.Chambers, T. Lecture XXIX on muscular atrophy. Lancet. 1864 347(1)96 .Google Scholar
12.Murray, T. The saint, the king's grandson, the poet, and the Victorian writer: instances of MS when the disease did not have a name. IJMSC. 1999 3(2)1 .Google Scholar
13.Stolberg, M. Experiencing illness and the sick body in early modern Europe. 2011 BasingstokePalgrave-MacMillan 417.CrossRefGoogle Scholar
14.McDonald, W. The dynamics of multiple sclerosis. J Neurol. 1993 240(1)2836.CrossRefGoogle ScholarPubMed
15.Charcot, J. Histologie de la sclérose en plaques. Gazette des Hopitaux. 1868 41(1)55466.Google Scholar
16.Clanet, M. Jean-Martin Charcot. 1825 to 1893. Int MS J. 2008 15(2)5961.Google ScholarPubMed
17.Charcot, J, Sigerson, Gt. Lectures on the diseases of the nervous system delivered at la Salpětrière. 1877 LondonNew Sydenham Society.Google Scholar
18.Osler, W. Cases of insular sclerosis. Can Med Surg J. 1880 9(1)111(Quotes on p. 10, 5–9, 8–9, 3, 4, and 9–10 respectively).Google Scholar
19.Maulitz, R. Morbid appearances: the anatomy of pathology in the early nineteenth century. 1987 New YorkCambridge University Press 938.CrossRefGoogle Scholar
20.Stahnisch, F, Stahnisch, F, Bauer, H. Mind the Gap: Synapsen oder keine Synapsen? – Bildkontrolle, Wortwechsel und Glaubenssaetze im Diskurs der morphologischen Hirnforschung. Bild und Gestalt: Wie formen Medienpraktiken das Wissen in Medizin und Humanwissenschaften? 2007 MuensterLIT-Press 10124.Google Scholar
21.Talley, C. The emergence of multiple sclerosis, 1870–1950: a puzzle of historical epidemiology. Perspect Biol Med. 2005 48(3)38395.CrossRefGoogle ScholarPubMed
22.Parkinson, J. An essay on the shaking palsy. J Neuropsychiatry Clin Neurosci. 2002 14(2)22336.CrossRefGoogle ScholarPubMed
23.Lees, A. Unresolved issues related to the shaking palsy on the celebration of James Parkinson's 250th birthday. Mov Disord. 2007 22 S17S32734.CrossRefGoogle Scholar
24.Kempster, P, Hurwitz, B, Lees, A. A new look at James Parkinson's essay on the shaking palsy. Neurology. 2007 69(5)4825.CrossRefGoogle Scholar
25.Butler, M, Bennett, T. In search of a conceptualization of multiple sclerosis: a historical perspective. Neuropsychol Rev. 2003 13(2)93112.CrossRefGoogle ScholarPubMed
26.Polman, C, Reingold, S, Banwell, B. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011 69(2)292302.CrossRefGoogle Scholar
27.Differential symptoms of multiple cerebro-spinal sclerosis and paralysis agitans. Can J Med Sci. 1879;4(6):159.Google Scholar
28.Olek, M. Multiple sclerosis: etiology, diagnosis, and new treatment strategies. 2005 New YorkHumana Press.CrossRefGoogle Scholar
29.Zesiewicz, T, Sullivan, K, Amulf, I. Practice parameter: treatment of nonmotor symptoms of Parkinson disease: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2010 74(11)924 .CrossRefGoogle Scholar
30.Gross, R, Siderowf, A, Hurtig, H. Cognitive impairment in Parkinson's disease and Dementia with Lewy Bodies: a spectrum of disease. Neurosignals. 2008 16(1)2434.CrossRefGoogle Scholar
31.Jankovic, J. Parkinson's disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry. 2008 79(4)371 .CrossRefGoogle ScholarPubMed
32.Osler, W. Society Proceedings – Medico-Chirurgical Society of Montreal, February 29th, 1884. Can Med Surg J. 1884 12(10)598605(quotes on p. 0 and 1 respectively).Google Scholar
33.Xu, J, Rasmussen, I, Lagopoulos, J, Haberg, A. Diffuse axonal injury in severe traumatic brain injury visualized using high-resolution diffusion tensor imaging. J Neurotrauma. 2007 24(5)75365.CrossRefGoogle ScholarPubMed
34.Marra, C. Update on Neurosyphilis. Curr Infect Dis Rep. 2009 11(2)12734.CrossRefGoogle ScholarPubMed
35.Quetel, C, Braddock, J, Pike, B. Syphilis as a cultural phenomenon. History of Syphilis. 1992 BaltimoreJohns Hopkins University 18.Google Scholar
36.Locomotor ataxy not tabes dorsalis Can Pract. 1884;9(2):44..Google Scholar
37.Rodger, T. Society Proceedings – Medico-Chirurgical Society of Montreal, June 27th, 1884. Can Med Surg J. 1884 13(4)23642(Quotes on p. 40, 41 respectively).Google Scholar
38.Samuel R. Dictionary of Canadian Biography Online 2000 September 1, 2011 [cited 2012 September 9]; Available from: http://www.biographi.ca/.Google Scholar
39.Russell, J. The value of the reflexes in diagnosis. Can Pract Rev. 1908 33(9)563 .Google Scholar
40.McCully, O. The clinical significance of vertigo. Maritime Med News. 1903 15(10)4447.Google Scholar
41.Conversion Disorder. Diagnostic and statistical manual of mental disorders. 4 (text revision) ed. Washington: The American Psychiatric Association; 2000. p. 492–8..Google Scholar
42.Bogousslavsky, J. Hysteria after Charcot: back to the future. Front Neurol Neurosci. 2011 29(1)13761.CrossRefGoogle ScholarPubMed
43.Charcot, J. Neue Vorlesungen ueber die Krankheiten des Nervensystems insbesondere ueber Hysterie. 1886 LeipzigToeplitz and Deuticke.Google Scholar
44.Crafts, L. The early recognition of multiple sclerosis. JAMA. 1917 69(14)11307.CrossRefGoogle Scholar
45.Jones, A. The differential diagnosis of paraplegia. Can Pract Rev. 1910 35(1)18(Quote on p. 7).Google Scholar
46.Brinar, V, Habek, M, Brinar, M, Malojčić, B, Boban, M. The differential diagnosis of acute transverse myelitis. Clin Neurol Neurosurg. 2006 108(3)27883.CrossRefGoogle ScholarPubMed
47.Shefner, J, Mackin, G, Dawson, D. Lower motor neuron dysfunctuon in patients with multiple sclerosis. Muscle Nerve. 1992 15(11)126570.CrossRefGoogle ScholarPubMed
48.Misawa, S, Kuwabara, S, Mori, M, Hayakawa, S, Sawai, S, Hattori, T. Peripheral nerve demyelination in multiple sclerosis. Clin Neurophysiol. 2008 119(8)182933.CrossRefGoogle ScholarPubMed
49.Butler, M, Corboy, J, Filley, C. How the conflict between American psychiatry and neurology delayed the appreciation of cognitive dysfunction in multiple sclerosis. Neuropsychol Rev. 2009 19(3)399410.CrossRefGoogle ScholarPubMed
50.Brown, S, Davis, T, Dana, C, Jelliffe, S, Riley, H, Tilney, F, Timme, W. The mental symptoms of multiple sclerosis. Multiple Sclerosis (Disseminated Sclerosis) – An investigation by the Association for Research in Nervous and Mental Diseases. 1922 New YorkHoeber 98104.Google Scholar
51.Berrios, G, Quemada, J., Andre, G. Ombredane and the psychiatry of multiple sclerosis: a conceptual and statistical history. Compr Psychiatry. 1990 31(5)43846.CrossRefGoogle ScholarPubMed
52.Romberg, M, Sieveking, Et. A manual of the nervous diseases of man. 1853 LondonSydenham Society.Google Scholar
53.Roddick, T. Society Proceedings – Canadian Medical Association. Twenty-ninth annual meeting, Montreal, August 26th, 27th and 28th, 1896. Montreal Med J. 1896 25(3)25862.Google Scholar
54.Hunt, A, Sethi, K. The pull test: A history. Mov Disord. 2006 21(7)8949.CrossRefGoogle ScholarPubMed
55.Louis, E. Weir Mitchell's 1859 demonstration of “a peculiar contraction” produced by a percussion hammer. Neurology. 2008 70(12)96973.CrossRefGoogle ScholarPubMed
56.Louis, E. Erb and Westphal: simultaneous discovery of the deep tendon reflexes. Semin Neurol. 2002 22(4)38590.CrossRefGoogle ScholarPubMed
57.Ferguson, J. Pseudo-Tabes. Can Med Surg J. 1888 16(9)52634(Quote on p. 7).Google Scholar
58.Russell, J. The value of reflexes in diagnosis – address in medicine, Canadian Medical Association, Ottawa, June 10, 1908. Maritime Med News. 1908 20(9)32734(Quote on p. 30).Google Scholar
59.Ravin, J. Argyll Robertson: ‘twas better to be his pupil than to have his pupil. Ophthalmology. 1998 105(5)86770.CrossRefGoogle Scholar
60.von Wassermann, A, Neisser, A, Bruck, C. Eine serodiagnostische Reaktion bei Syphilis. Dtsch Med Wochenschr. 1906 32(19)745 .CrossRefGoogle Scholar
61.Hoag, D. The Wassermann reaction – its clinical value. Can Pract Rev. 1910 35(4)23541(Quote on p. 9).Google Scholar
62.Spinal cord tumors. Maritime Med News. 1910;22(4):99–101..Google Scholar
63.Nonne, M. Clinical diagnosis of the syphilogenous diseases of the central nervous system. JAMA. 1909 53(4)28696.CrossRefGoogle Scholar
64.Apelt, F. The significance of cytological examination of the cerebro-spinal fluid. Can Pract Rev. 1907 32(7)419 .Google Scholar
65.Nonne, M, Apelt, F. Ueber fractionierte Eiweissausfaellung in der Spinalfluessigkeit von Gesunden, Luetikern, functionell und organisch Nervenkranken und ueber ihre Verwertung zur Differentialdiagnose der Dementia paralytica, Tabes dorsalis, tertiaeren und abgelaufenen Syphilis. Arch Psychiatr Nervenkr. 1908 43(1)43360.CrossRefGoogle Scholar
66.Holmes, H. Multiple sclerosis. Professional guide to diseases. 2008 9 ed.PhiladelphiaLippincott Williams and Wilkins 224 .Google Scholar
67.Dana, C, Dana, C, Jelliffe, S, Riley, H, Tilney, F, Timme, W. Multiple sclerosis and the methods of ecology. Multiple Sclerosis (Disseminated Sclerosis) – An investigation by the Association for Research in Nervous and Mental Diseases. 1922 New YorkHoeber 438.Google Scholar
68.Wechsler, I, Dana, C, Jelliffe, S, Riley, H, Tilney, F, Timme, W. Statistics of multiple sclerosis. Multiple Sclerosis (Disseminated Sclerosis) – An investigation by the Association for Research in Nervous and Mental Diseases. 1922 New YorkHoeber 2643(Quote on p. 34).Google Scholar
69.Gunn, R. Retro-ocular neuritis. Montreal Med J. 1905 34(2)148 .Google Scholar
70.Cameron, D, Jones, I. John Snow, the Broad Street Pump and modern epidemiology. Int J Epidemiol. 1983 12(4)3936.CrossRefGoogle Scholar
71.Rushmore, J., William Browning, M.D. July 7, 1855-January 5, 1941. Bull Med Libr Assoc. 1893 29(3)1856.Google Scholar
72.Nervous Affection Caused by Malaria. Ontario Med J. 1893;1(8):347..Google Scholar
73.Adami, John George. 1862–1926. J Pathol Bacteriol. 1927 30(1)15167.Google Scholar
74.Obituary – A.G. Nicholls. BMJ. 1946;1(4459):969..CrossRefGoogle Scholar
75.Oskar Koltz 1878–1936. J Pathol Bacteriol. 1936;44(2):504–7..CrossRefGoogle Scholar
76.Adami, J, Nicholls, A, Koltz, O. The year's progress in bacteriology – the bacteriology of the infective diseases. Montreal Med J. 1909 38(5)3415.Google Scholar
77.Hamburger, W. The ocular typhoid reaction – preliminary report of a modification of the ocular test of Chantemesse. JAMA. 1908 50(17)13445.CrossRefGoogle Scholar
78.Lang, H, Jacobsen, H, Ikemizu, S. A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Nat Immunol. 2002 3(10)9403.CrossRefGoogle ScholarPubMed
79.Camp, C, White, W, Jelliffe, S. Paralysis agitans and multiple sclerosis and their treatment. The modern treatment of nervous and mental diseases. 1913 PhiladelphiaLea and Febiger 66170.Google Scholar
80.White, W. Dr. Van Gieson, an obituary. Am J Insanity. 1913 69(1)8013.Google Scholar
81.Van Gieson, I. The relation of toxic agents to the production of nervous and mental diseases. Can Pract. 1897 22(5)3589(Quote on p. 9).Google Scholar
82.Thums, K. Das Erblichkeitsproblem bei der Multiplen Sklerose. Muenchner Med Wchnschr. 1938 86(1)16348.Google Scholar
83.MacKay, R, Myrianthopoulos, N. Multiple sclerosis in twins and their relatives: preliminary report on a genetic and clinical study. Arch Neurol Psychiat. 1958 80(6)66774.CrossRefGoogle ScholarPubMed
84.Myrianthopoulos, N, MacKay, R. Multiple sclerosis in twins and their relatives: genetic analysis of family histories. Acta Genet. 1960 10 1–33347.Google ScholarPubMed
85.Smith, S, Penrose, L. Monozygotic and dizygotic twin diagnosis. Ann Human Genet. 1955 19(4)27389.CrossRefGoogle ScholarPubMed
86.MacKay, R. The Familial Occurrence of Multiple Sclerosis and its Implications. Ann Intern Med. 1950 33(2)298320.Google ScholarPubMed
87.MacKay, R, Myrianthopoulos, N. Multiple sclerosis in twins and their relatives: final report. Arch Neurol Psychiat. 1966 15(5)44962.CrossRefGoogle Scholar
88.Willer, C, Dyment, D, Risch, N, Sadovnick, A, Ebers, G. Twin concordance and sibling recurrence rates in multiple sclerosis. Proc Natl Acad Sci. 2003 100(22)1287782.CrossRefGoogle ScholarPubMed
89.Mumford, C, Wood, N, Kellar-Wood, H, Thorpe, J, Miller, D, Compston, D. The British Isles survey of multiple sclerosis in twins. Neurology. 1994 44(1)115.CrossRefGoogle ScholarPubMed
90.Nerve-stretching. Can J Med Sci. 1882;7(4):119–20 (Quote on p. 20)..Google Scholar
91.Swank, R. Multiple sclerosis: a correlation of its incidence with dietary fat. Am J Med Sci. 1950 220(4)42130.CrossRefGoogle ScholarPubMed
92.Schaltenbrand, G. Die Multiple Sklerose Des Menschen. 1943 LiepzigThieme.Google Scholar
93.Swank, R, Lerstad, O, Stroem, A, Backer, J. Multiple sclerosis in rural Norway: its geographic and occupational incidence in relation to nutrition. New Engl J Med. 1952 246(19)7218.CrossRefGoogle ScholarPubMed
94.Ganesh, A, Stahnisch, FW. On the historical succession of vessel-based therapies in the treatment of multiple sclerosis. Eur Neurol. 2013 70 1–24858.CrossRefGoogle ScholarPubMed
95.Swank, R, Duncan, B. The Multiple Sclerosis Diet Book. 1987 New YorkDoubleday.Google Scholar
96.Swank, R. Treatment of multiple sclerosis with low-fat diet. Arch Neurol Psychiat. 1953 69(1)91103.CrossRefGoogle ScholarPubMed
97.Wilmot, V, Swank, R. The influence of low-fat diet on blood lipid levels in health and in multiple sclerosis. Am J Sci. 1952 223(1)2534.Google ScholarPubMed
98.Swank, R. Treatment of multiple sclerosis with low-fat diet: result of seven years' experience. Ann Intern Med. 1956 45(5)81224.Google ScholarPubMed
99.Swank, R. Multiple sclerosis: twenty years on low fat diet. Arch Neurol. 1970 23(5)46074.CrossRefGoogle ScholarPubMed
100.Swank, R, Goodwin, J. Review of MS patient survival on a Swank low saturated fat diet. Nutrition. 2003 19(2)1612.CrossRefGoogle ScholarPubMed
101.Vogt, P. Traumatic tetanus cured by stretching the nerves of the brachial plexus. BMJ. 1877 1(840)137 .Google Scholar
102.Sterling, J, Heymann, W. Potassium iodide in dermatology: A 19th century drug for the 21st century – Uses, pharmacology, adverse effects, and contraindications. J Am Acad Dermatol. 2000 43(4)6917.CrossRefGoogle ScholarPubMed
103.West, S. Selection – rational therapeutics and the use of common remedies. Maritime Med News. 1896 8(7)21626(Quotes on p. 7 and 8 respectively).Google Scholar
104.Matters Medical – Quackery in the profession. Maritime Med News. 1900;12(9):337–8 (Quote on p. 337)..Google Scholar
105.Lipids and multiple sclerosis. Lancet. 1990;336(8706):25–6..CrossRefGoogle Scholar
106.Ben-Shlomo, Y, Smith, G, Marmot, M. Dietary fat in the epidemiology of multiple sclerosis: has the situation been adequately assessed?. Neuroepidemiology. 1992 11 4–621425.CrossRefGoogle ScholarPubMed
107.Byrnes, C. The treatment of multiple sclerosis. JAMA. 1922 78(12)86773.Google Scholar
108.Talley, C. The treatment of multiple sclerosis in Los Angeles and the United States, 1947–1960. Bull Hist Med. 2003 77(4)87499.CrossRefGoogle ScholarPubMed
109.Murray, T, Burks, J, Johnson, K. The History of Multiple Sclerosis. Multiple Sclerosis: Diagnosis, Medical Management, and Rehabilitation. 2000 New YorkDemos Medical Publishing 27 .Google Scholar
110.Boyer L. What is the history of the MUHC Multiple Sclerosis Program? 2003 July 8 2003 [cited 2013 July 25]; Available from: http://www.msclinic.ca/msweb/msprogram.htm.Google Scholar
111.Talley, C, Packard, R. The Combined Efforts of Community and Science: American Culture, Patient Activism, and the Multiple Sclerosis Movement in the United States. Emerging Illnesses and Society: Negotiating the Public Health Agenda. 2004 BaltimoreJohns Hopkins University Press 3970.Google Scholar
112.Evelyn Opal Society. 2009 August 10 [cited 2013 July 25]; Available from: http://mssociety.ca/legacy/pdf/Legacy%20giving%20brochure%20EN.pdf.Google Scholar
113.History. 2012 10 August 2012 [cited 2013 July 4]; Available from: http://mssociety.ca/en/community/mssc/history.htms.Google Scholar
114.Penfield, W. Donald Snell McEachern, M.D. 1904–1951. Arch Neurol Psychiat. 1952 67(2)2678.CrossRefGoogle Scholar
115.Putnam, T. The centenary of multiple sclerosis. Arch Neurol Psychiat. 1938 4(4)80613(Quote on p. 813).CrossRefGoogle Scholar