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Haloperidol-Induced Dyskinesias in the Monkey

Published online by Cambridge University Press:  18 September 2015

P. Bédard ,
J. Delean ,
J. Lafleur  and
L. Larochelle
P. Bédard*
Affiliation:
Laboratoires de Neurobiologie, Québec, Canada
J. Delean
Affiliation:
Laboratoires de Neurobiologie, Québec, Canada
J. Lafleur
Affiliation:
Laboratoires de Neurobiologie, Québec, Canada
L. Larochelle
Affiliation:
Laboratoires de Neurobiologie, Québec, Canada
*
Laboratoires de Neurobiologie, Pavilion Notre-Dame, 2075 ave de Vitré, Québec, QUE., Canada G1J 5B3
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Haloperidol (0.25 mglkg i.m.) was injected daily for 6 months in six normal monkeys. Over a 24 hour period, the following symptoms could he observed: akathisia, circling, akinesia, choreoathetoid and dystonic movements, oro-facial dyskinesias and postural tremor with or without harmaline. Six months after cessation of haloperidol, harmaline-induced postural tremor could still be observed in all animals and oro-facial abnormal movements, in one monkey. The neuropathologic study of the experimental material did not disclose any alteration of the central nervous system.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 4 , Issue 3 , August 1977 , pp. 197 - 201
Copyright
Copyright © Canadian Neurological Sciences Federation 1977

References

REFERENCES

Ayd, F.J. (1961). A survey of drug-induced extrapyramidal reactions. JAMA: 175. 1054–1060.CrossRefGoogle ScholarPubMed
Baruk, H., Launay, J. and Berges, J. (1956). Physiologie psychiatrique expérimentale de la chlorpromazine chez les animaux et ses applications thérapeutiques chez l’homme. Encéphale: 45, 1258–1263.Google Scholar
Battista, A.F., Goldstein, M. and Ogawa, M. (1971). Production of involuntary movements by L-DOPA in monkeys with tegmental lesions. Exp. Neurol.: 33, 566–575.CrossRefGoogle ScholarPubMed
Bedard, P., Larochelle, L., Poirier, L.J. and Sourkes, T.L. (1970) . Reversible effect of L-DOPA on tremor and catatonia induced by a-methyl-p-tyrosine. Can. J. Physiol. Pharmacol.: 48, 82–84.CrossRefGoogle Scholar
Cammermayer, J. (1969). Neuro-pathological study of rhesus chronically treated with chlorpromazine, in A multi-disciplinary workshop: Psychotropic drugs and dysfunctions of the basal ganglia. Washington, Public Health Service Publication No. 1938, pp 19–20.Google Scholar
Carpenter, M.B., Whittier, J.R. and Mettler, F.A. (1950). Analysis of choreoid hyperkinesia in the rhesus monkey. J. Comp. Neur.: 92, 293–332.CrossRefGoogle ScholarPubMed
Christensen, E., Moller, J.E. and Faurbye, A. (1970). Neuropathological investigation of 28 brains from patients with dyskinesia. Acta Psychiat. Scand.: 46, 14–23.CrossRefGoogle ScholarPubMed
Crane, G.E. (1968). Tardive dyskinesia in patients treated with major neuroleptics. A review of the literature. Amer. J. Psychiat.: 124 (suppl.) 40–48.CrossRefGoogle ScholarPubMed
Deneau, G. and Crane, G.E. (1969). Dyskinesia in rhesus monkeys tested with high doses of chlorpromazine, in A multi-disciplinary workshop: Psychotropic drugs and dysfunctions of the basal ganglia. Washington, Public Health Service Publication No. 1938. pp. 12–14.Google Scholar
Hokfelt, T. and Fuxe, K. (1969). Cerebellar monoamine nerve terminals a new type of afferent fibers to the cortex cere-belli. Exp. Brain Res.: 9. 63–72.CrossRefGoogle Scholar
Janssen, P.A.J. (1967). The pharmacology of haloperidol. Int. J. Neuropsychiat.: 3, 10–18.Google ScholarPubMed
Janssen, P.A.J., Soudijn, W., Van Wijngaarden, I. and Dresse, A. (1968). Pimozide: a chemically novel, highly potent and orally long-acting neuroleptic drug. Arzneimittel forschung.: 18, 280–287.Google ScholarPubMed
Kennard, M.A. (1944). Experimental analysis of the functions of the basal ganglia in monkeys and chimpanzees. J. Neurophysiol.: 7. 127–148.CrossRefGoogle Scholar
Larochelle, L., Bedard, P., Boucher, R. and Poirier, L.J. (1970). The rubro-olivo-cerebello-rubral loop and postural tremor in the monkey. J. Neurol. Sci.: 11, 53–64.CrossRefGoogle ScholarPubMed
Larochelle, L., Bedard, P., Poirier, L.J. and Sourkes, T.L. (1971) . Correlative neuroanatomical and neuropharmacological study of tremor and catatonia in the monkey. Neuropharmacol.: 10. 273–288.CrossRefGoogle ScholarPubMed
Mones, R.J. (1973). Experimental dyskinesias in normal rhesus monkey. In: Bar-beau, A., Chase, T.N. and Paulson, G.W. (Eds). Advances in Neurology, vol. 1, Huntington’s Chorea, 1872–1972, Raven Press, New York, pp. 665–669.Google Scholar
Paulson, G.W. (1973). Dyskinesias in monkeys. In: Barbeau, A., Chase, T.N. and Paulson, G.W. (Eds), Advances in Neurology, vol. 1, Huntington’s Chorea 1872–1972. Raven Press, New York, pp. 647–650.Google Scholar
Poirier, L.J. (1960). Experimental and histological study of midbrain dyskinesia. J. Neurophysiol.: 23, 534–551.CrossRefGoogle Scholar
Poirier, L.J. (1970). Recent views on tremors and their treatment. In: Williams, D. (Ed), Modern trends in Neurology, vol. 5. Butterworths. London, pp. 80–95.Google Scholar
Poirier, L.J., Sourkes, T.L., Bouvier, G., Boucher, R. and Carabin, S. (1966). Striatal amines, experimental tremor and the effect of har-maline in the monkey. Brain: 89, 37–52.CrossRefGoogle Scholar
Scarlato, G., Pelligrini, G. (1967). Recherches sur la distribution dans le rat de l’haloperidol marqué au tritium. Psychopharmacologia: 11, 165–173.CrossRefGoogle Scholar