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Fluoxetine and Selegiline – Lack of Significant Interaction

Published online by Cambridge University Press:  18 September 2015

C.H. Waters
C.H. Waters*
Affiliation:
Division of Movement Disorders, Department of Neurology, University of Southern California, Los Angeles, California
*
Department of Neurology, University of Southern California, 1510 San Pablo Street, Suite 615, Los Angeles, California, USA 90033
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Abstract:

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The use of the combination of fluoxetine, an anti-depressant serotonin uptake inhibitor, and selegiline, a monoamine oxidase -B inhibitor, was reviewed in a large population of patients with Parkinson’s disease. All records were reviewed from a Parkinson’s disease clinic to determine how many patients were treated simultaneously with selegiline and fluoxetine. Patient characteristics, duration and dose of treatment, side effects and reasons for discontinuation were noted. Twenty-three patients received both medications at the same time. No additional side effects were noted with the combination therapy that had not already been reported with each medication alone. No serious side effects were found. In this clinic population, fluoxetine and selegiline were used in combination without major side effects, but further observation is warranted.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 21 , Issue 3 , August 1994 , pp. 259 - 261
Copyright
Copyright © Canadian Neurological Sciences Federation 1994

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