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Familial Cerebral Amyloid Angiopathy Due to the Iowa Mutation in an Irish Family

Published online by Cambridge University Press:  20 October 2014

Tzehow Mok ,
Albi J. Chalissery ,
Susan Byrne ,
Lisa Costelloe ,
Leo Galvin ,
Harry V. Vinters ,
Michael A. Farrell ,
Francesca M. Brett  and
Joan T. Moroney
Tzehow Mok*
Affiliation:
Department of Neurology, Beaumont Hospital and Royal College of Surgeons Ireland, Dublin, Ireland
Albi J. Chalissery
Affiliation:
Department of Neurology, Beaumont Hospital and Royal College of Surgeons Ireland, Dublin, Ireland
Susan Byrne
Affiliation:
Department of Neurology, Beaumont Hospital and Royal College of Surgeons Ireland, Dublin, Ireland
Lisa Costelloe
Affiliation:
Department of Neurology, Beaumont Hospital and Royal College of Surgeons Ireland, Dublin, Ireland
Leo Galvin
Affiliation:
Department of Neuroradiology, Beaumont Hospital and Royal College of Surgeons Ireland, Dublin, Ireland
Harry V. Vinters
Affiliation:
Section of Neuropathology, Department of Neurology, UCLA Medical Center, Los Angeles, California, USA
Michael A. Farrell
Affiliation:
Department of Neuropathology, Beaumont Hospital and Royal College of Surgeons Ireland, Dublin, Ireland
Francesca M. Brett
Affiliation:
Department of Neuropathology, Beaumont Hospital and Royal College of Surgeons Ireland, Dublin, Ireland
Joan T. Moroney
Affiliation:
Department of Neurology, Beaumont Hospital and Royal College of Surgeons Ireland, Dublin, Ireland
*
Department of Neurology, Beaumont Hospital, Dublin 9, Dublin, Ireland. Email: [email protected].
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Abstract

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Type
Brief Communications
Information
Canadian Journal of Neurological Sciences , Volume 41 , Issue 4 , July 2014 , pp. 512 - 517
Copyright
Copyright © The Canadian Journal of Neurological 2014

References

1.Maia, LF, Mackenzie, IR, Feldman, HH.Clinical phenotypes of cerebral amyloid angiopathy. J Neurol Sci. 2007;257:23–30.CrossRefGoogle ScholarPubMed
2.Grabowski, TJ, Cho, HS, Vonsattel, JP, Rebeck, GW, Greenberg, SM.Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy. Ann Neurol. 2001;49:697–705.CrossRefGoogle Scholar
3.Greenberg, SM, Shin, Y, Grabowski, TJ, et al. Hemorrhagic stroke associated with the Iowa amyloid precursor protein mutation. Neurology. 2003;60:1020–2.CrossRefGoogle ScholarPubMed
4.Iglesias, S, Chapon, F, Baron, JC.Familial occipital calcifications, hemorrhagic strokes, leukoencephalopathy, dementia, and external carotid dysplasia. Neurology. 2000;55:1661–7.CrossRefGoogle ScholarPubMed
5.Krone, MG, Baumketner, A, Bernstein, SL, et al. Effects of familial Alzheimer's disease mutations on the folding nucleation of the amyloid beta-protein. J Mol Biol. 2008;381:221–8.CrossRefGoogle ScholarPubMed
6.Vinters, HV, Natte, R, Maat-Schieman, MLC, et al. Secondary microvascular degeneration in amyloid angiopathy of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D). Acta Neuropathol. 1998;95:235–44.CrossRefGoogle ScholarPubMed
7.Biffi, A, Sonni, A, Anderson, CD, et al. International Stroke Genetics Consortium. Variants at APOE influence risk of deep and lobar intracerebral hemorrhage. Ann Neurol. 2010;68:934–43.Google Scholar
8.Biffi, A, Anderson, CD, Jagiella, JM, et al. APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study. Lancet Neurol. 2011;10(8)702–9.CrossRefGoogle ScholarPubMed
9.Rannikmäe, K, Kalaria, RN, Greenberg, SM, et al. APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis. J Neurol Neurosurg Psychiatry. 2014;85:300–5.CrossRefGoogle ScholarPubMed
10.Shin, Y, Cho, HS, Fukumoto, H, et al. Abeta species, including IsoAsp23 Abeta, in Iowa-type familial cerebral amyloid angiopathy. Acta Neuropathol. 2003;105:252–8.CrossRefGoogle ScholarPubMed