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Electrophysiological Analysis of Human Neocortex In Vitro: Experimental Techniques and Methodological Approaches

Published online by Cambridge University Press:  18 September 2015

M. Avoli ,
G.G.C. Hwa ,
G. Kostopoulos ,
A. Olivier  and
J.-G. Villemure
M. Avoli*
Affiliation:
Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal
G.G.C. Hwa
Affiliation:
Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal
G. Kostopoulos
Affiliation:
Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal
A. Olivier
Affiliation:
Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal
J.-G. Villemure
Affiliation:
Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal
*
Room 804, Montreal Neurological Institute, 3801 University, Montreal, Quebec, Canada H3A 2B4
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Abstract:

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In this review we summarize a number of technical and methodological approaches that have been used in our laboratory to study human brain slices maintained in vitro. The findings obtained in the course of these studies appear to be relevant in establishing he mechanisms that underlie physiological phenomena of the human brain such as synaptic plasticity or responses to neuroactive drugs. Moreover, these data are important for understanding certain fundamental mechanisms of epilepsy. In this respect, however, we aution that the mechanisms that apply to different forms of clinical epilepsy might be ifficult to find given the variability present in the pathogenesis of human epilepsy.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue S4 , November 1991 , pp. 636 - 639
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

References

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