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Effects of Ethyl Ester Derivatives of Valproic Acid Metabolites on Pentylenetetrazol Seizures in Mice

Published online by Cambridge University Press:  18 September 2015

J. Bruni ,
E.J. Hammond  and
B.J. Wilder
J. Bruni*
Affiliation:
Department of Neurology, University of Florida, College of Medicine, Gainesville, Florida, U.S.A.
E.J. Hammond
Affiliation:
Department of Neurology, University of Florida, College of Medicine, Gainesville, Florida, U.S.A.
B.J. Wilder
Affiliation:
Department of Neurology, University of Florida, College of Medicine, Gainesville, Florida, U.S.A.
*
Suite 318, E.K. Jones Building, Wellesley Hospital, 160 Wellesley St. East. Toronto, Ontario, Canada, M4Y 1J3. (416) 966-6723
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Summary:

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The anticonvulsant activity of the ethyl esters of the major valproic acid metabolites was assessed against minimal pentylenetetrazol seizures in adult male ICR mice. The ethyl ester 3-hydroxy-propylpentanoic acid was found to possess significant anticonvulsant activity.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 8 , Issue 3 , August 1981 , pp. 259 - 261
Copyright
Copyright © Canadian Neurological Sciences Federation 1981

References

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