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Effect of Asparagine, Glutamine and Insulin on Cerebral Amino Acid Neurotransmitters

Published online by Cambridge University Press:  18 September 2015

Roger F. Butterworth ,
France Landreville ,
Edith Hamel ,
Andrea Merkel ,
François Giguere  and
André Barbeau
Roger F. Butterworth
Affiliation:
Clinical Research Institute of Montreal
France Landreville
Affiliation:
Clinical Research Institute of Montreal
Edith Hamel
Affiliation:
Clinical Research Institute of Montreal
Andrea Merkel
Affiliation:
Clinical Research Institute of Montreal
François Giguere
Affiliation:
Clinical Research Institute of Montreal
André Barbeau*
Affiliation:
Clinical Research Institute of Montreal
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada, H2W 1R7
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Treatment of rats with asparagine or glutamine caused substantial increases in glutamine concentrations in cerebellum and medulla oblongata. Insulin treatment caused a diminution of glutamate and GA BA in these regions of brain. Since it is now well-established that glutamine is a very efficient precursor of the neurotransmitter pool of glutamate in mammalian brain, treatment with asparagine or glutamine could be of therapeutic (replacement) value in the treatment of neurological disorders such as Friedreich's ataxia, in which cerebral glutamate concentrations have been found to be diminished.

Type
Quebec Cooperative Study on Friedreich's Ataxia
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 4 , November 1980 , pp. 447 - 450
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

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