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Ecogenetics of Parkinson's Disease: Prevalence and Environmental Aspects in Rural Areas

Published online by Cambridge University Press:  18 September 2015

André Barbeau
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal, University of Montreal
Madeleine Roy*
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal, University of Montreal
Gilles Bernier
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal, University of Montreal
Giuseppe Campanella
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal, University of Montreal
Suzanne Paris
Affiliation:
Department of Neurobiology, Clinical Research Institute of Montreal, University of Montreal
*
Department of Neurobiology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
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Abstract:

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We make use of the unique combination of a homogeneous genetic and racial origin in the rural population of Quebec and the facilities of free and universal access to medical care, to study the distribution of the prevalence of Parkinson's disease in the 9 rural hydrographic regions of the Province. Through 3 different methods of ascertainment, confirmed by two control probes, we demonstrate that the prevalence of Parkinson's disease is of uneven distribution within rural areas. We further investigated the characteristics of the regions of high prevalence. These regions which are predominantly agricultural and areas of intensive market gardening were also the areas with the highest use of pesticides.

Type
Original Articles
Copyright
Copyright © Canadian Neurological Sciences Federation 1987

References

1.Barbeau, A. Etiology of Parkinson’s disease: A research strategy. Can J Neurol Sci 1984; 11: 2428.CrossRefGoogle ScholarPubMed
2.Barbeau, A, Cloutier, T, Roy, M, Plasse, L, Paris, S, Poirier, J. Ecogenetics of Parkinson’s disease: The 4-hydroxylation of debrisoquine. Lancet 1985; 2: 12131216.CrossRefGoogle ScholarPubMed
3.Marttila, RJ, Rinne, UK. Epidemiology of Parkinson’s disease — An overview. J Neurol Transm 1981; 51: 135148.CrossRefGoogle ScholarPubMed
4.Kurland, LT. Epidemiology: Incidence, geographic distribution and genetic considerations.. In: Fields, WS (editor). Pathogenesis and Treatment of Parkinsonism. Springfield, II, Charles C Thomas, Publisher, 1958; pp. 549.Google Scholar
5.Eldridge, R, Rocca, WA. The clinical syndrome of striatal dopamine deficiency: Parkinsonism induced by MPTP. New Engl J Med 1983; 313: 11591160.Google Scholar
6.Cotzias, GC. Manganese, melanin and the extrapyramidal system. J Neurosurg. 1966; 24: 170180.Google ScholarPubMed
7.Barbeau, A. Manganese and extrapyramidal disorders. Neurotoxicology 1984; 5: 1336.Google ScholarPubMed
8.Yanagihara, R, Garruto, RM, Gajdusek, DCet al. Calcium and Vitamin D metabolism in Guamanian Chamorros with amyotrophic lateral sclerosis and parkinsonism-dementia. Ann Neurol 1984; 15: 4248.CrossRefGoogle ScholarPubMed
9.Garruto, RM, Yahagihara, R, Gajdusek, C. Disappearance of high incidence amyotrophic lateral sclerosis and parkinsonism-dementia on Guam. Neurology 1985; 35: 193198.CrossRefGoogle ScholarPubMed
10.Rajput, AH, Stern, A, Christ, A, Laverty, W. Etiology of Parkinson’s disease: Environmental Factor(s). Neurology 1984; 34(3): 207.Google Scholar
11.Langston, JW, Ballard, P, Tetrud, JW. et al. Chronic parkinsonism secondary to intravenous injection of meperidine analogues. Science 1983; 219: 979980.CrossRefGoogle Scholar
12.Barbeau, A, Roy, M, Langston, JW. Neurological consequence of industrial exposure to l-methyl-4-phenyl-l,2,3.6-tetrahydropyridine. Lancet 1985; 1: 747.CrossRefGoogle Scholar
13.Burns, RS, Chiueh, CC, Markey, SPEbert, MH, Jacobowitz, DM, Kopin, IJ. A primate model of Parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-l,2,3,6-tetrahydropyridine. Proc Natl Acad Sci USA 1983; 80: 45464550.CrossRefGoogle Scholar
14.Barbeau, A, Dallaire, L, Buu, NT, et al. New amphibian models for the study of l-methyl-4-phenyl-l ,2,3,6-tetrahydropyridine (MPTP). Life Sci 1985; 36: 11251134.CrossRefGoogle Scholar
15. Barbeau, A, Dallaire, L, Buu, NT, et al. Comparative behavioral, biochemical and pigmentary effects of MPTP. MPP+ and Paraquat in Rana Pipiens. Life Sci 1985; 37: 15291538.CrossRefGoogle ScholarPubMed
16.Snyder, SH, D’Amato, RJ. Predicting Parkinson’s disease. Nature 1985; 317: 198199.CrossRefGoogle ScholarPubMed
17.Testa, B, Naylor, R, Costall, B, Jenner, P, Marsden, CD. et al. Does an endogenous methylpyridinium analogue cause Parkinson’s disease? J Pharm Pharmacol 1985; 37: 679680.CrossRefGoogle ScholarPubMed
18.de Pedro, J, Rosenqvist, U. Tracers for Paralysis Agitans in epidemiological research. I. Analysis of Swedish drug-use registrers and tracer selection. Neuroepidemiology 1984; 3: 8296.CrossRefGoogle Scholar
19.de Pedro, J, Rosenqvist, U. Tracers for Paralysis Agitans in epidemiological research. II. A model for indirect estimation of the prevalence of the disease. Neuroepidemiology 1984; 3: 97107.CrossRefGoogle Scholar
20. Anonymous. Carte des bassins hydrographiques de Québec. Bureaud’etude sur les substances toxiques. Gouvernement du Québec,service de protection de I’environnement, Québec 1984Google Scholar
21.Joe, S.Estimation de la population des municipalitués du Quuébec auler juin 1983. Bureau de la statistique du Quuébec. Québec 1964; pp. 1142.Google Scholar
22.Labrecque, J, Thibault, M. Atlas de Iu’agro-alimentaire du Quuébec.2e édiion, Ministuère de I‘Agriculture. Québec 1978; pp. 170.Google Scholar
23. Anonymous. 1981 Census of Canada. Agriculture-Quebec. Catalogue 96-906. Statistics Canada. Ottawa 1982.Google Scholar
24.Reiss, R, Perron, F, paré, J, et al. Les pesticides au Quebec en 1982.Environnement-Canada et Environnement-Québec. Québec. 1984: pp. 1134.Google Scholar
25. Anonymous. Pares industriels du Québec.Ministère de l’lndustrie, du Commerce et du Tourisme. Québec 1984: pp. 176.Google Scholar
26. Anonymous. 1981 Census of Canada. Population, occupied privatedwellings, private households, census families in private house holds. Selected characteristics: Quebec. Catalogue 93-917. Statistics Canada, Ottawa. 1982.Google Scholar
27.Colton, T., Statistics in medicine. Boston, Little, Brown & Co 1974; pp. 1372.Google Scholar
28.Kulkarni, AP, Hodgson, E. The metabolism of insecticides: the role of monooxygenase enzymes. Ann Rev Pharmacol Toxicol 1984; 24: 1942.CrossRefGoogle Scholar
29.Ghali, GZ, Hollingworth, RM. Influence of mixed function oxygenase metabolism on the acute neurotoxicity of the pesticidechlordimeform in mice. Neurotoxicology 1984; 6: 215238.Google Scholar
30.Wong, TK, Everson, RB, Hsu, S-T. Potent induction of human placental monooxygenase activity by previous dietary exposureto polychlorinated biphenyls and their thermal degradationproducts. The Lancet 1985; 1: 721724.CrossRefGoogle Scholar
31.Agrawal , AK, Tilson, HA, Bondy, SC. 3,4,3′,4′-tetrachloro-biphenyl given to mice prenatally produced long-term decreases in striatal dopamine and receptor binding sites in caudate nucleus. Toxicol Lett 1981; 7: 417424.CrossRefGoogle ScholarPubMed
32.Seegal, RF, Bush, B, Brosh, KO. Polychlorinated biphenyls induce regional changes in brain norepinephrine concentrations in adult rats. Neurotoxicol 1985; 6: 1324.Google ScholarPubMed