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Disease Progression and Sphingolipids and Neurofilament Light Chain in Early Idiopathic Parkinson’s Disease

Published online by Cambridge University Press:  29 August 2023

Blas Couto Open the ORCID record for Blas Couto [Opens in a new window] ,
Mario Sousa ,
Paulina Gonzalez-Latapi ,
Eric McArthur ,
Anthony Lang ,
Alice Chen-Plotkin  and
Connie Marras
Blas Couto
Affiliation:
Edmond J. Safra Program in Parkinson’s Disease, Rossy Program for PSP Research and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada Institute of Cognitive and Traslational Neuroscience (INCyT), at the INECO-CONICET-Favaloro University Hospital, Buenos Aires, Argentina
Mario Sousa
Affiliation:
Department of Neurology, Inselspital, Bern University Hospital, Bern, Switzerland Graduate School for Health Sciences, University of Bern, Bern, Switzerland
Paulina Gonzalez-Latapi
Affiliation:
Ken and Ruth Davee Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
Eric McArthur
Affiliation:
London Health Sciences Centre, London, ON, Canada
Anthony Lang
Affiliation:
Edmond J. Safra Program in Parkinson’s Disease, Rossy Program for PSP Research and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada
Alice Chen-Plotkin
Affiliation:
Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Connie Marras*
Affiliation:
Edmond J. Safra Program in Parkinson’s Disease, Rossy Program for PSP Research and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada
*
Corresponding author: C. Marras; E-mail: [email protected]
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Abstract:

Parkinson’s disease(PD) lacks a biomarker for disease progression. To analyze how cerebrospinal fluid (CSF), glucosylceramide (GlcCer), sphingomyelin (SM), or serum neurofilament light chain (NfL) associate with progression of PD in a retrospective cohort, we used linear mixed-model regressions between baseline biomarkers and change in dopamine transporter brain-imaging (DaTscan©), Montreal cognitive assesment (MoCA), or global composite outcome (GCO) score. In 191 PD patients, biomarkers were not associated with DaTscan or MoCA change over 2.1 years. Higher baseline GlcCer/SM ratio and serum-NfL nonsignificantly associated with increase in GCO score. Results do not support a role for CSF-sphingolipid/serum-NfL to predict cognitive and DaTscan progression in early-PD. Potential prediction of global clinical change warrants further study.

Résumé :

RÉSUMÉ :

Il n’existe pas de biomarqueur de la progression de la maladie de Parkinson (MP). Pour analyser comment le glucosylcéramide (GlcCer) et la sphingomyéline (SM) du liquide cérébrospinal (LCS) ou encore les neurofilaments à chaîne légère (NFCL) du sérum sont associés à la progression de la MP dans une cohorte rétrospective, nous avons utilisé des régressions linéaires à modèle mixte entre les biomarqueurs de base et l’évolution de résultats obtenus lors d’examens d’IRM du transporteur de la dopamine (DaTscan©) ainsi qu’au moyen du Montreal Cognitive Assessment (MoCA) ou du score Global Composite Outcome (GCO). Chez 191 patients atteints de la MP, les biomarqueurs n’ont pas été associés à l’évolution des résultats du DaTscan© ou du MoCA au cours d’une période de 2,1 ans. Un rapport GlcCer/SM de base plus élevé et les NFCL du sérum ont par ailleurs été associés de manière non notable à l’augmentation du score GCO. Ces résultats ne confirment donc pas le rôle de la SM du LCS et des NFCL dans la prédiction de la progression cognitive et des résultats au DaTscan© au début de la MP. En somme, la prédiction potentielle de l’évolution clinique globale de cette maladie mérite d’être étudiée plus avant.

Keywords

Parkinson diseaseprogressionspectcognitionsphingolipidbiomarkers
Type
Brief Communication
Information
Canadian Journal of Neurological Sciences , Volume 51 , Issue 4 , July 2024 , pp. 573 - 576
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of Canadian Neurological Sciences Federation

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