Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-27T14:44:42.952Z Has data issue: false hasContentIssue false
  • English
  • Français

Discrimination of the Cognitive Profiles of MCI and Depression using the KBNA

Published online by Cambridge University Press:  23 September 2014

Michelle C. E. Monette  and
Larry Leach
Michelle C. E. Monette
Affiliation:
Department of Psychology, University of Windsor, Windsor
Larry Leach*
Affiliation:
Neuropsychology & Cognitive Health Program, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
*
Neuropsychology & Cognitive Health Program, Baycrest Centre for Geriatric Care, Toronto, Ontario, M6a 2E1, Canada. Email: [email protected]
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Objective:

The current study sought to determine if the Kaplan-Baycrest Neurocognitive Assessment (KBNA) was capable of discriminating individuals with subjective memory complaints associated with depression from individuals with mild cognitive impairment (MCI).

Methods:

Scores on 12 subtests of the KBNA were compared for 27 participants with MCI and 28 participants being treated for depression using Bonferroni correct between-group comparisons for each subtest. KBNA subtest scores were corrected for age and education.

Results:

Significant between-group differences were obtained on six subtests with large effect sizes (Cohen's d) ranging from 1.19 - 1.58. The six subtests involved encoding and delayed episodic memory for verbal and visual information. Using logistic regression analysis, five subtests of the KBNA were able to correctly classify 96.4% of study participants.

Conclusion:

The results from this preliminary investigation indicate that the KBNA has the potential to serve as a brief and reliable assessment tool capable of distinguishing individuals with subjective memory complaints associated with depression from individuals with MCI in a clinical setting. Limitations of the current study and future research are discussed.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 40 , Issue 5 , September 2013 , pp. 670 - 677
Copyright
Copyright © The Canadian Journal of Neurological 2013

References

1.Engmann, B.Mild cognitive impairment in the elderly. GeroPsych. 2011; 24: 71–6.CrossRefGoogle Scholar
2.Steffens, DC, Potter, GG.Geriatric depression and cognitive impairment. Psychol Med. 2008; 38: 163–75.CrossRefGoogle ScholarPubMed
3.Belleville, S, Chertkow, H, Gauthier, S.Working memory and control of attention in persons with Alzheimer's disease and mild cognitive impairment. Neuropsychology. 2007; 21: 458–69.CrossRefGoogle ScholarPubMed
4.Fischer, C, Schweizer, TA, Atkins, JH, et al.Neurocognitive profiles in older adults with and without major depression. Int J Geriatr Psychiatry. 2008; 23: 851–6.CrossRefGoogle ScholarPubMed
5.Defrancesco, M, Marksteiner, J, Deisenhammer, EA, Hinterhuber, H, Weiss, EM.Association of mild cognitive impairment (MCI) and depression. Neuropsychiatrie. 2009; 23: 144–50.Google ScholarPubMed
6.Panza, F, Frisardi, V, Capurso, C, et al.Late-life depression, mild cognitive impairment, and dementia: Possible continuum. Am J Geriatr Psychiatry. 2010; 18: 98–116.CrossRefGoogle ScholarPubMed
7.Dierckx, E, Engelborghs, S, De Raedt, R, De Deyn, PP, Ponjaert-Kristoffersen, I.Differentiation between mild cognitive impairment, Alzheimer's disease and depression by means of cued recall. Psychol Med. 2007; 37: 747–55.CrossRefGoogle ScholarPubMed
8.Zihl, J, Reppermund, S, Thum, S, Unger, K.Neuropsychological profiles in MCI and in depression: Differential cognitive dysfunction patterns or similar final common pathway disorder? J Psychiatr Res. 2010; 44: 647–54.CrossRefGoogle ScholarPubMed
9.Bhalla, RK, Butters, MA.Cognitive functioning in late-life depression. BCMJ. 2011; 53: 357–60.Google Scholar
10.Herrmann, LL, Goodwin, GM, Ebmeier, KP.The cognitive neuropsychology of depression in the elderly. Psychol Med. 2007; 37: 1693–1702.CrossRefGoogle ScholarPubMed
11.Steffens, DC.Separating mood disturbance from mild cognitive impairment in geriatric depression. Int Rev Psychiatr. 2008; 20:374–81.CrossRefGoogle ScholarPubMed
12.Sheline, YI, Barch, DM, Garcia, K, et al.Cognitive function in late life depression: Relationships to depression severity, cerebrovascular risk factors and processing speed. Biol Psychiatry. 2006; 60: 58–65.CrossRefGoogle ScholarPubMed
13.Modrego, PJ, Ferrandez, J.Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: A prospective cohort study. Arch Neurol, 2004; 61: 1290–3.CrossRefGoogle ScholarPubMed
14.Petersen, RC, Doody, R, Kurz, A, et al.Current concepts in MCI. Arch Neurol. 2001; 58: 1985–92.CrossRefGoogle Scholar
15.Mitchell, AJ.Is it time to separate subjective cognitive complaints from the diagnosis of mild cognitive impairment? Age Ageing. 2008; 37: 497–9.CrossRefGoogle ScholarPubMed
16.Petersen, RC, Smith, GE, Waring, SC, Ivnik, RJ, Tangalos, EG, Kokmen, E.Mild cognitive impairment: clinical characterization and outcome. Arch Neuro. 1999; 56: 303–8.CrossRefGoogle ScholarPubMed
17.Alladi, S, Arnold, R, Mitchell, J, Nestor, P, Hodges, JR.Mild cognitive impairment: Applicability of research criteria in a memory clinic and characterization of cognitive profile. Psychol Med. 2006;36: 507–15.CrossRefGoogle Scholar
18.Lonie, JA, Herrmann, LL, Donaghey, CL, Ebmeier, KP.Clinical referral patterns and cognitive profile in mild cognitive impairment. Br J Psychiatry. 2008; 192: 59–64.CrossRefGoogle ScholarPubMed
19.Kavé, G, Heinik, J.Neuropsychological evaluation of mild cognitive impairment: Three case reports. Clin Neuropsychol. 2004; 18: 362–72.CrossRefGoogle ScholarPubMed
20.Nordlund, A, Rolstad, S, Hellström, P, Sjögren, M, Hansen, S, Wallin, A.The Goteborg MCI study: Mild cognitive impairment is a heterogeneous condition. J Neurol Neurosurg Psychiatry. 2005;76: 1485–90.CrossRefGoogle ScholarPubMed
21.Petersen, RC.Mild Cognitive Impairment. New york: Oxford University Press; 2003.CrossRefGoogle ScholarPubMed
22.Sikkes, SAM, Van den Berg, MT, Knol, DL, et al.How useful is the IQCODE for discriminating between Alzheimer's disease, mild cognitive impairment and subjective memory complaints? Dement Geriatr Cogn Disord. 2010; 30: 411–6.CrossRefGoogle ScholarPubMed
23.Zakzanis, KK, Leach, L, Kaplan, E.On the nature and pattern of neurocognitive function in major depressive disorder. Neuropsychiatry Neuropsychol Behav Neurol. 1998; 11: 111–9.Google ScholarPubMed
24.Leach, L, Kaplan, E, Rewilak, D, Richards, B, Proulx, G.Kaplan Baycrest Neurocognitive Assessment Manual. San Antonio, TX: Psychological Corporation; 2000Google Scholar
25.Leach, L.The diagnostic prediction of the Kaplan-Baycrest Neurocognitive Assessment for identification of mild dementia. Arch Clin Neuropsych. 2010; 25: 359–70.CrossRefGoogle ScholarPubMed
26.Foldi, NS, Brickman, AM, Schaefer, LA, Knutelska, ME.Distinct serial position profiles and neuropsychological measures differentiate late life depression from normal aging and Alzheimer's disease. Psychiatry Res. 2003; 120: 71–84.CrossRefGoogle ScholarPubMed
27.Petersen, RC, Morris, JC.Clinical Features. In, RC Petersen, editors. Mild cognitive impairment: Aging to Alzheimer's disease. New York: Oxford University Press; 2003. p. 15–40.CrossRefGoogle Scholar
28.APA. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR, 4th ed., text revision. American Psychiatric Association: Washington, DC; 2000.Google Scholar
29.Reisberg, B, Ferris, SH, de Leon, MJ, Crook, T.The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry, 1982; 139: 1136–9.Google ScholarPubMed