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The Discovery, Proof and Reproof of Neurosecretion: (Speidel, 1917; Scharrer and Scharrer, 1934)

Published online by Cambridge University Press:  18 September 2015

Harvey B. Sarnat
Harvey B. Sarnat*
Affiliation:
Faculty of Medicine, University of Calgary, Calgary, Alberta
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Seventeen years before the Scharrers demonstrated neurosecretory activity of neurons within the brains of vertebrates and invertebrates and convinced the scientific world of the existence of a neuroendocrine system, Carl Caskey Speidel (1917) had identified glandular neurons in the spinal cord of the skate, postulated a neurosecretory function, and performed experiments to prove his hypothesis. The correct conclusions that he formulated from morphologic observations were not believed by biologists until ‘proved’ by the Scharrers, who acknowledged his pioneering contributions. The Scharrers studied many species and even demonstrated neurosecretion in nemertine worms, now believed to be closely related to the ancestors of all vertebrates. Evolutionary theorists had speculated on neuroglandular function as early as 1900, and the contributions of comparative neuroanatomists to this field have resulted in a major medical advance.

Type
Historical Perspective
Information
Canadian Journal of Neurological Sciences , Volume 10 , Issue 3 , August 1983 , pp. 208 - 212
Copyright
Copyright © Canadian Neurological Sciences Federation 1983

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