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CSF Electrophoresis in One Thousand Patients

Published online by Cambridge University Press:  18 September 2015

G.C. Ebers  and
D.W. Paty
G.C. Ebers*
Affiliation:
Department of Clinical Neurological Sciences, University Hospital, University of Western Ontario, London, Ontario, Canada
D.W. Paty
Affiliation:
Department of Clinical Neurological Sciences, University Hospital, University of Western Ontario, London, Ontario, Canada
*
Division of Neurology, University Hospital, 339 Windermere Road, London, Ontario N6A 5A5 Canada
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Agarose and/or cellulose acetate electrophoresis was performed on the CSF of one thousand patients. In patients with clinically definite multiple sclerosis (MS) (N = 267) 92.8% had oligoclonal banding (O.B.). In patients with possible MS (N - 283) O.B. was present in 31.1%. In patients with other neurological diseases (N = 450) O.B. was present in 8% (N = 36). Nineteen non-MS patients with positive O.B. had serum bands or disorders known to be associated with local immune response. The remaining 17 patients had no explanation for the oligoclonal banding. In the majority of these MS had not been a diagnostic consideration.

CSF electrophoresis is the single most reliable laboratory lest in multiple sclerosis and deserves incorporation into the diagnostic criteria for the disease.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 4 , November 1980 , pp. 275 - 280
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

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