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Cross Correlation Studies in Primate Motor Cortex: Synaptic Interaction and Shared Input

Published online by Cambridge University Press:  18 September 2015

John T. Murphy ,
Hon C. Kwan  and
Yiu C. Wong
John T. Murphy*
Affiliation:
Departments of Physiology and Medicine, University of Toronto
Hon C. Kwan*
Affiliation:
Departments of Physiology and Medicine, University of Toronto
Yiu C. Wong*
Affiliation:
Departments of Physiology and Medicine, University of Toronto
*
11–241 Eaton North, Toronto General Hospital, 101 College Street, Toronto, Ontario, Canada M5G 1L7
11–241 Eaton North, Toronto General Hospital, 101 College Street, Toronto, Ontario, Canada M5G 1L7
11–241 Eaton North, Toronto General Hospital, 101 College Street, Toronto, Ontario, Canada M5G 1L7
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Abstract:

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Awake, unrestrained monkeys were trained to reach out with the forelimb and touch a button. Extracellular spike trains were recorded from pairs of neurons in contralateral precentral cortex with the same or separate microelectrodes. The neurons were located in the same or different functional columns as defined by intracortical microstimulation and passive sensory stimulation. Cross correlation analysis showed patterns consistent with synaptic excitation and/or inhibition between members of the cell pairs during the voluntary movement. The strength of correlation was inversely related to distance between columns, with the strongest correlations found between cells within the same column. Inhibitory correlations were virtually restricted to cell pairs within a single column. Temporal analysis showed that direct synaptic interaction and shared input patterns could be clearly distinguished in this physiologic setting. Spatial analysis indicated that shared input was concentrated among columns in the same and adjacent joint controlling zones as well as within a single column. No directional preference of shared input was present, a finding which was consistent with the observed nested organization of the forelimb area.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 12 , Issue 1 , February 1985 , pp. 11 - 23
Copyright
Copyright © Canadian Neurological Sciences Federation 1985

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