Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-23T20:25:04.087Z Has data issue: false hasContentIssue false
  • English
  • Français

Clustering of Parkinson's Disease in Southern Israel

Published online by Cambridge University Press:  18 September 2015

Y.O. Herishanu ,
J.R. Goldsmith ,
J.M. Abarbanel  and
Z. Weinbaum
Y.O. Herishanu*
Affiliation:
Neurology Department, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel
J.R. Goldsmith
Affiliation:
Epidemiology and Health Services Evaluation Unit, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel
J.M. Abarbanel
Affiliation:
Neurology Department, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel
Z. Weinbaum
Affiliation:
Epidemiology and Health Services Evaluation Unit, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel
*
Department of Neurology, Soroka University Medical Center, POB 151, Beer-Sheva, Israel
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

On three adjacent kibbutzim (collective rural communities) in the Negev (Southern Israel) 13 parkinsonian patients were found among a population of 592 persons 40 years or older. The clinical picture was not different from that of patients from other areas with idiopathic parkinsonism. Long term residence in the kibbutzim is characteristic of this population. In the past most of the drinking water has been supplied by wells from a common aquifer. From other patients with Parkinson's disease in the Negev, we estimated the age-specific incidence for the region. The incidence is about five times greater in each of these kibbutzim than in the remainder of the Negev. Although associations with rural residence and well water use have been reported elsewhere, clusters of this sort have not been reported. They strongly suggest that a common environmental factor exists.

Résumé:

RÉSUMÉ:

Nous avons recensé 13 parkinsoniens dans trois kibbutzim (agglomérations rurales collectives) voisins dans le Négev (sud de l'état d'Israël) parmi une population de 592 personnes âgées de 40 ans et plus. Leur tableau clinique n'était pas différent de celui qu'on retrouve chez les patients présentant un parkinsonisme idiopathique dans d'autres régions. Cette population réside dans le kibbutz depuis longtemps. Dans le passé, l'eau potable provenait en majeure partie de puits rejoignant la même nappe phréatique. À partir des données globales pour le Négev, nous avons estimé l'incidence régionale par âge. L'incidence est à peu près de cinq fois supérieure dans chacun de ces kibbutzim que dans le reste du Négev. Même si l'association avec un lieu de résidence rural et la consommation d'eau de puits a été rapportée ailleurs, une telle agrégation de cas n'a pas été rapportée antérieurement. Cette observation suggère fortement qu'un facteur environnemental commun existe dans ces lieux.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 16 , Issue 4 , November 1989 , pp. 402 - 405
Copyright
Copyright © Canadian Neurological Sciences Federation 1989

References

REFERENCES

1. Rosati, G, Granieri, E, Pinna, L, Aiello, I, et al. The risk of Parkinson’s disease in Mediterranean people. Neurology 1980; 30: 250–255.CrossRefGoogle ScholarPubMed
2. Harada, H, Nishikawa, S, Takahashi, K. Epidemiology of Parkinson’s disease in a Japanese city. Arch Neurol 1983; 40: 151–154.CrossRefGoogle Scholar
3. Mutch, WJ, Dingwall-Fordyce, I, Downie, AW, Paterson, JG, Roy, SK. Parkinson’s disease in a Scottish city. Br Med J (Clin Res) 1986; 292: 534–536.CrossRefGoogle Scholar
4. Calne, DB, Langston, JW. Aetiology of Parkinson’s disease. Lancet 2 1983; 1457–1459.CrossRefGoogle ScholarPubMed
5. Rajput, AH, Uitti, RJ, Stern, W, Laverty, W. Early onset Parkinson’s disease in Saskatchewan-environmental considerations for etiology. Can J Neurol Sci 1986; 13: 312–316.CrossRefGoogle ScholarPubMed
6. Barbeau, A, Roy, M, Bernier, G, Campanella, G, Paris, S. Ecogenetics of Parkinson’s disease: prevalence and environmental aspects in rural areas. Can J Neurol Sci 1987; 14: 36–41.CrossRefGoogle ScholarPubMed
7. Schoenberg, BS. Environmental risk factors for Parkinson’s disease: the epidemiologic evidence. Can J Neurol Sci 1987; 14: (Suppl 3)407–413.CrossRefGoogle ScholarPubMed
8. Marttila, RJ, Rinne, VK. Epidemiology of Parkinson’s disease in Finland. Acta Neurol Scand 1976; 53: 82–102.Google ScholarPubMed
9. Kessler, II. Parkinson’s disease in epidemiologic perspective. In: Shoenberg, B.S., ed. Adv. in Neurology Vol. 19, 1978; 355–384.Google ScholarPubMed
10. Barbeau, A. Etiology of Parkinson’s disease: a research strategy. Can J Neurol Sci 1984; 11: 24–28.CrossRefGoogle ScholarPubMed
11. Bocchetta, A, Corsini, GV. Parkinson’s disease and pesticides. Lancet 2 1986; 1163.CrossRefGoogle ScholarPubMed
12. Langston, JW, Ballard, P, Tetrud, JW, Irwin, I. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 1983; 219: 979–980.CrossRefGoogle ScholarPubMed
13. Ferraz, HB, Bertolucci, PHF, Pereira, JS, Lima, JGC, Andrade, LAF. Chronic exposure to the fungicide maneb may produce symptoms and signs of CNS manganese intoxication. Neurology 1988; 38: 550–553.CrossRefGoogle Scholar
14. Peters, HA, Levine, RL, Mattews, CG, Chapman, LJ. Extrapyramidal and other neurologic manifestations associated with carbon disulfide fumigant exposure. Arch Neurol 1988; 45: 537–540.CrossRefGoogle ScholarPubMed