Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-12-03T19:07:05.298Z Has data issue: false hasContentIssue false
  • English
  • Français

Clinical Differences Between Metoclopramide- and Antipsychotic-Induced Tardive Dyskinesias

Published online by Cambridge University Press:  18 September 2015

Anthony E. Lang
Anthony E. Lang*
Affiliation:
Movement Disorders Clinic, Toronto Western Hospital, Toronto
*
Movement Disorders Clinic, Toronto Western Hospital, 25 Leonard Avenue, #101, Toronto, Ontario, Canada M5T 2R2
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A patient with tardive dyskinesia dominated by pelvic thrusting movements is described. A retrospective review of the clinical features documented in patients with metoclopramide- and antipsychotic-induced tardive dyskinesias seen over a six year period demonstrated that the occurrence of pronounced pelvic thrusting and respiratory dyskinesias were significantly more common in the metoclopramide treated group. The occurrence of bucco-linguomasticatory movements, limb stereotypies or chorea, and mild truncal or abdominal rocking were not significantly different between the two groups. None of the tardive dystonia patients had metoclopramide as the causative agent. These findings will require confirmation in larger, better matched patient populations. Whether the differences relate to different pharmacologic profiles of drug action, patient populations exposed, or other factors, remains to be elucidated.

Résumé:

RÉSUMÉ:

Nous décrivons le cas d'un patient présentant des dyskinésies tardives dont l'élément principal consistait en des mouvements de projection du bassin. Une revue rétrospective des manifestations cliniques observées chez les patients présentant des dyskinésies tardives induites par le métoclopramide et les antipsychotiques et ayant consulté sur une période de six ans, a démontré que l'apparition de mouvements marqués de projection du bassin et de dyskinésies respiratoires était significativement plus fréquente dans le groupe recevant du métoclopramide. L'apparition de mouvements bucco-linguo-masticatoires, de stéréotypies ou de chorée des membres et d'un léger bercement du tronc ou de l'abdomen n'était pas significativement différente chex les deux groupes. Le métoclopramide n'était l'agent causal chez aucun des patients présentant une dystonie tardive. Ces observations demandent confirmation dans des populations de patients plus grandes et mieux appariées. Il reste à déterminer si les différences observées ont trait à des profils pharmacologiques différents de l'activé de ces médicaments, à des différences entre les populations de patients exposés ou à d'autres facteurs.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 17 , Issue 2 , May 1990 , pp. 137 - 139
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

References

REFERENCES

1. Bateman, DN, Rawlins, MD, Simpson, JM. Extrapyramidal reactions with metoclopramide. Br Med J 1985; 291: 930–932.CrossRefGoogle ScholarPubMed
2. Swett, C. Drug-induced dystonia. Am J Psychiatry 1975; 132: 532–534.Google ScholarPubMed
3. Lavy, S, Melamed, E, Penchos, S. Tardive dyskinesia associated with metoclopramide. Br Med J 1978; 1: 77–78.CrossRefGoogle ScholarPubMed
4. Kataria, M, Traub, M, Marsden, CD. Extrapyramidal side-effects of metoclopramide. Lancet 1978; 2: 1254–1255.CrossRefGoogle ScholarPubMed
5. Stanley, M, Ortrosen, J, Lautin, A, et al. Tardive dyskinesia and metoclopramine. Lancet 1979; 2: 1190.CrossRefGoogle Scholar
6. Grimes, JD, Hassan, MN, Preston, DN. Adverse neurologic effects of metoclopramide. Can Med Assoc J 1982; 126: 23–25.Google ScholarPubMed
7. Grimes, JD, Hassan, MN, Krelina, M. Long-term follow-up of tardive dyskinesia due to metoclopramide. Lancet 1982; 2: 563.CrossRefGoogle ScholarPubMed
8. Indo, T, Ando, K. Metoclopramide-induced parkinsonism: Clinical characteristics of 10 cases. Arch Neurol 1982; 39: 494–496.CrossRefGoogle Scholar
9. Wiholm, B-E, Mortimer, O, Boethius, G, Haggstrom, JE. Tardive dyskinesia associated with metoclopramide. Br Med J 1984; 288: 545–547.CrossRefGoogle ScholarPubMed
10. Orme, ML’E, Tallis, RC. Metoclopramide and tardive dyskinesia in the elderly. Br Med J 1984; 289: 397–398.CrossRefGoogle ScholarPubMed
11. Leopold, NA. Prolonged metoclopramide-induced dyskinetic reactions. Neurology (Cleveland) 1984; 34: 238–239.CrossRefGoogle Scholar
12. Shearer, RM, Bownes, IT, Curran, P. Tardive akathisia and agitated depression during metoclopramide therapy. Acta Psychiatr Scand 1984;70:428–431.CrossRefGoogle ScholarPubMed
13. Jankovic, J, Glass, JP. Metoclopramide-induced phantom dyskinesias. Neurology 1985; 35: 432–435.CrossRefGoogle Scholar
14. Breitpart, W. Tardive dyskinesia associated with high-dose intravenous metoclopramide. N Engl J Med 1986; 315: 518.Google Scholar
15. Board, AW. Tardive dyskinesia associated with high-dost intravenous metoclopramide. N Engl J Med 1986; 315: 518–519.Google Scholar
16. Patterson, JF. Choreiform movement associated with metoclopramide. South Med J 1986; 79: 1465.CrossRefGoogle ScholarPubMed
17. Beauclair, L, Fontains, R. Tardive dyskinesia associated with metoclopramide. Can Med Assoc J 1986; 134: 613–614.Google Scholar
18. Lazzara, RR, Stoudemire, A, Manning, D, et al. Metoclopramideinduced tardive dyskinesia: A case report. Gen Hosp Psych 1986; 8: 107–109.CrossRefGoogle ScholarPubMed
19. Patel, M, Louis, S. Long-term neurologic complications of metoclopramide. NY State J Med 1986; 86: 210.Google ScholarPubMed
20. Pall, HS, Williams, AC. Extrapyramidal disturbances caused by inappropriate prescribing. Br Med J 1987; 295: 30–31.CrossRefGoogle ScholarPubMed
21. Mahler, JC, Brown, RP. More on metoclopramide and tardive dyskinesia. N Engl J Med 1987; 316: 412.Google ScholarPubMed
22. Board, AW. More on metoclopramide and tardive dyskinesia. N Engl J Med 1987;316:412–413.Google Scholar
23. Samie, MR, Dannenhoffer, MA, Rozek, S. Life-threatening tardive dyskinesia caused by metoclopramide. Movement Disorders 1987; 2: 125–129.CrossRefGoogle ScholarPubMed
24. Yamamoto, M, Ujike, H, Ogawa, N. Metoclopramide-induced parkinsonism. Clin Neuropharmacol 1987; 10: 287–289.CrossRefGoogle ScholarPubMed
25. Burke, RE, Fahn, S, Jankovic, J, et al. Tardive dystonia: Late-onset and persistent dystonia caused by antipsychotic drugs. Neurology 1982; 32: 1335–1346.CrossRefGoogle ScholarPubMed
26. Hassan, MN, Reches, A, Kuhn, C, et al. Pharmacologic evaluation of dopaminergic receptor blockade by metoclopramide. Clin Neuropharmacol 1986;9:71–78.CrossRefGoogle ScholarPubMed
27. Kane, JM, Woerner, M, Borenstein, M, et al. Integrating incidence and prevalence of tardive dyskinesia. Psychopharmacol Bull 1986; 22: 254–258.Google ScholarPubMed
28. Waddington, JL, Youssef, HA. An unusual cluster of tardive dyskinesia in schizophrenia: Association with cognitive dysfunction and negative symptoms. Am J Psychiatry 1986; 143: 1162–1164.Google ScholarPubMed
29. Chouinard, G, Annabele, L, Mercier, P, et al. A five-year follow-up study of tardive dyskinesia. Psychopharmacol Bull 1986; 22: 259–263.Google ScholarPubMed