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Chronic Lymphocytic Leukemia Presenting as a Pituitary Mass Lesion

Published online by Cambridge University Press:  18 September 2015

Jonathan S. Fain ,
Faramarz Naeim ,
Donald P. Becker ,
Andre Van Herle ,
Frisca Yan-Go ,
Leonard Petrus  and
Harry V. Vinters
Jonathan S. Fain
Affiliation:
Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, California
Faramarz Naeim
Affiliation:
Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, California
Donald P. Becker
Affiliation:
Department of Surgery (Neurosurgery), UCLA Medical Center, Los Angeles, California
Andre Van Herle
Affiliation:
Department of Medicine, UCLA Medical Center, Los Angeles, California
Frisca Yan-Go
Affiliation:
Department of Neurology, UCLA Medical Center, Los Angeles, California
Leonard Petrus
Affiliation:
Department of Radiological Sciences, UCLA Medical Center, Los Angeles, California
Harry V. Vinters*
Affiliation:
Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, California
*
Division of Neuropathology, Department of Pathology and Laboratory Medicine, UCLA Medical Center, CHS 18–170, Los Angeles, California, U.S.A. 90024–1732
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Abstract:

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We describe a unique case of chronic lymphocytic leukemia (CLL) in a patient who presented with bitemporal hemianopsia, adrenal insufficiency, and gonadotrophin deficiency. Studies revealed an enhancing intrasellar mass with suprasellar extension and displacement of the optic chiasm. Peripheral blood and cerebrospinal fluid (CSF) studies disclosed a monoclonal IgM kappa expressing B-cell CLL. Biopsy of the pituitary mass revealed dense infiltration of the pituitary gland by leukemic cells. This is, to our knowledge, the first reported case of CLL presenting as a pituitary mass lesion.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 19 , Issue 2 , May 1992 , pp. 239 - 242
Copyright
Copyright © Canadian Neurological Sciences Federation 1992

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