Hostname: page-component-745bb68f8f-b95js Total loading time: 0 Render date: 2025-01-23T21:13:19.277Z Has data issue: false hasContentIssue false
  • English
  • Français

Cerebral Vein Thrombosis due to Hereditary Antithrombin III Deficiency

Published online by Cambridge University Press:  18 September 2015

Paul Tuite ,
Ferhaan Ahmad ,
Ian Grant ,
John D. Stewart ,
Stirling Carpenter  and
Romeo Ethier
Paul Tuite*
Affiliation:
Departments of Neurology and Neurosurgery, Montreal Neurological Hospital and Institute, and McGill University, Montreal
Ferhaan Ahmad
Affiliation:
Departments of Neurology and Neurosurgery, Montreal Neurological Hospital and Institute, and McGill University, Montreal
Ian Grant
Affiliation:
Departments of Neurology and Neurosurgery, Montreal Neurological Hospital and Institute, and McGill University, Montreal
John D. Stewart
Affiliation:
Departments of Neurology and Neurosurgery, Montreal Neurological Hospital and Institute, and McGill University, Montreal
Stirling Carpenter
Affiliation:
Departments of Neurology and Neurosurgery, Montreal Neurological Hospital and Institute, and McGill University, Montreal
Romeo Ethier
Affiliation:
Departments of Neurology and Neurosurgery, Montreal Neurological Hospital and Institute, and McGill University, Montreal
*
Montreal Neurological Institute, 3801 University, Room 365, Montreal, Quebec, Canada H3A 2B4
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Cerebral vein thrombosis, also called superior sagittal sinus thrombosis, is a well recognized clinical and radiologic entity associated with a variety of medical disorders. We report a patient with fatal cerebral vein thrombosis following myelography, in whom the cause was familial antithrombin III (AT3) deficiency. Unsuspected AT3 deficiency should be considered in cases of unexplained cerebral venous thromboses.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 20 , Issue 2 , May 1993 , pp. 158 - 161
Copyright
Copyright © Canadian Neurological Sciences Federation 1993

References

1.Imai, WK, Everhart, FR, Sanders, JM. Cerebral venous thrombosis: report of a case and review of the literature. Pediatrics 1982; 70: 965–970.CrossRefGoogle ScholarPubMed
2.Vines, FS, Davis, DO. Clinical radiological correlation in cerebral venous occlusive disease. Radiology 1971; 98: 9–22.CrossRefGoogle ScholarPubMed
3.Steinherz, PG. Dural sinus thrombosis in children with acute lymphoblastic leukemia. JAMA 1981; 246: 2837–2839.CrossRefGoogle ScholarPubMed
4.Gettelfinger, DM, Kokmen, E. Superior sagittal sinus thrombosis. Arch Neurol 1977; 34: 2–6.CrossRefGoogle ScholarPubMed
5.Kalbag, RM, Woolf, AL. Cerebral Venous Thrombosis. London: Oxford University Press 1967.Google Scholar
6.Ambruso, DR, Jacobson, LJ, Hathaway, WE. Inherited antithrombin III deficiency and cerebral thrombosis in a child. Pediatrics 1980; 65: 125–131.CrossRefGoogle ScholarPubMed
7.Hathaway, WE. Clinical aspects of antithrombin III deficiency. Semin Hematol 1991; 28: 19–23.Google ScholarPubMed
8.Rosenberg, RD. Actions and interactions of antithrombin and heparin. N Engl J Med 1975; 292: 146–151.Google ScholarPubMed
9.Rosenberg, RD, Bauer, KA. Thrombosis in inherited deficiencies of antithrombin, protein, C, and protein, S.Hum Pathol 1987; 18: 253–262.CrossRefGoogle ScholarPubMed
10.Buller, HR, ten, Cate JW. Acquired antithrombin III deficiency: laboratory diagnosis, incidence, clinical implications and treatment with antithrombin III concentrate. Am J Med 1989; 87 (Suppl 3B): 44S–48S.CrossRefGoogle ScholarPubMed
11.Hirsh, J, Piovella, F, Pini, M. Congenital antithrombin III deficiency: incidence and clinical features. Am J Med 1989; 87 (Suppl 3B): 34S–38S.CrossRefGoogle ScholarPubMed
12.Vikydal, R, Korninger, C, Kyrle, PA. The prevalence of hereditary antithrombin-III deficiency in patients with a history of venous thromboembolism. Thromb Haemost 1985; 54: 744–745.Google ScholarPubMed
13.Matsuo, O. Incidence of thrombosis in inherited antithrombin III deficiency. Thromb Res 1981; 24: 509–510.CrossRefGoogle ScholarPubMed
14.Lee, M-K, Ng, S-C. Cerebral venous thrombosis associated with antithrombin III deficiency. Aust NZ J Med 1991; 21: 772–773.CrossRefGoogle ScholarPubMed
15.Vomberg, PP, Breedeweld, C, Fleury, P, Arts, WF. Cerebral throm-boembolism due to antithrombin III deficiency in two children. Neuropediatrics 1987; 17:42–44.CrossRefGoogle Scholar
16.Filip, DJ, Eckstein, JD, Veltcamp, JJ. Hereditary antithrombin III deficiency and thromboembolic disease. Am J Hematol 1976; 2: 343–349.CrossRefGoogle Scholar
17.Halpern, JP, Morris, JGL, Driscoll, GL. Anticoagulants and cerebral venous thrombosis. Aust NZ J Med 1984; 14: 643–648.CrossRefGoogle ScholarPubMed
18.Einhiiupl, KM, Villringer, A, Meister, W, et al.Heparin treatment in sinus venous thrombosis. Lancet 1991; 338: 597–600.CrossRefGoogle Scholar
19.Enevoldson, TP, Ross-Russell, RW. Heparin treatment in sinus venous thrombosis. Lancet 1991; 338: 1153–1154.CrossRefGoogle Scholar
20.Shiozawa, Z. Superior sagittal sinus thrombosis and systemic lupus erythematosus. Ann Neurol 1986; 20: 270.CrossRefGoogle ScholarPubMed
21.Di, Rocco CD, Iannelli, A. Heparin-urokinase treatment in aseptic dural sinus thrombosis. Arch Neurol 1981; 38: 431–435.Google Scholar